Kallikrein

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Current revision (09:12, 8 September 2019) (edit) (undo)
 
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</StructureSection>
</StructureSection>
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== 3D Structures of kallikrein ==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*Kallikrein 1
 
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**[[1gvz]] – KLK - horse <br />
 
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**[[2pka]] – pKLK - pig <br />
 
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**[[2kai]] – pKLK + BPTI <br />
 
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**[[1hia]] – pKLK + hirustasin <br />
 
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*Kallikrein 2
 
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**[[4nfe]] – hKLK + inhibitor - human <br />
 
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**[[4nff]] – hKLK + PPACK <br />
 
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*Kallikrein 4
 
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**[[6nvb]] – hKLK <br />
 
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**[[4kga]] – hKLK + Ni<br />
 
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**[[2bdg]] – hKLK + aminobenzamidine + Ni <br />
 
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**[[2bdh]] – hKLK + aminobenzamidine + Zn<br />
 
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**[[2bdi]] – hKLK + aminobenzamidine + Co<br />
 
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**[[4k1e]], [[4kel]], [[4k8y]], [[6o21]] – hKLK + trypsin inhibitor <br />
 
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**[[6kbr]] – hKLK + SPINK2 inhibitor <br />
 
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*Kallikrein 5
 
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**[[2psx]] – hKLK catalytic domain + leupeptin<br />
 
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**[[2psy]] – hKLK catalytic domain + leupeptin + Zn<br />
 
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**[[6qfe]] – hKLK + inhibitor <br />
 
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*Kallikrein 6
 
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**[[1gvl]] – hKLK (mutant) <br />
 
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**[[1l2e]], [[1lo6]] – hKLK + inhibitor <br />
 
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**[[3vfe]], [[4d8n]], [[6qff]], [[6qfg]], [[6qfh]], [[6qf9]], [[6qfa]], [[6qfb]], [[6qfc]] – hKLK (mutant) + inhibitor <br />
 
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**[[5nx1]], [[5nx3]] – hKLK + amyloid-b A4 protein<br />
 
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*Kallikrein 7
 
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**[[3bsq]] – hKLK <br />
 
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**[[2qxg]], [[2qxh]], [[2qxi]], [[2qxj]] – hKLK + chymotriptic determinant <br />
 
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**[[5fah]], [[5y9l]], [[5yjk]] – hKLK + inhibitor<br />
 
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**[[5zfh]] – mKLK - mouse<br />
 
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**[[5zfi]], [[6ahs]] – mKLK + inhibitor<br />
 
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*Kallikrein 8
 
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**[[5ms3]] – hKLK <br />
 
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**[[5ms4]] – hKLK + inhibitor<br />
 
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*Kallikrein 10
 
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**[[5lpf]] – hKLK <br />
 
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**[[5lpe]] – hKLK + Zn<br />
 
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*Kallikrein 13
 
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**[[1ao5]] – KLK - mouse<br />
 
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*Plasma kallikrein
 
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**[[6o1g]], [[6i44]] – hKLK + inhibitor<br />
 
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**[[4ogx]], [[4ogy]] – hKLK light chain (mutant) + antibody <br />
 
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**[[5f8z]] – hKLK light chain (mutant) + Pkalin-1 <br />
 
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**[[5f8t]] – hKLK light chain (mutant) + Pkalin-2 <br />
 
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**[[5f8x]] – hKLK light chain (mutant) + Pkalin-3 <br />
 
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**[[5tjx]], [[2anw]], [[2any]], [[6o1s]] – hKLK light chain (mutant) + inhibitor <br />
 
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**[[5gvt]] – mKLK protease domain (mutant) <br />
 
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**[[6a8o]] – mKLK protease domain + inhibitor<br />
 
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*Tissue kallikrein (KLK 1)
 
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**[[1spj]] – hKLK (mutant) <br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of human kallikrein 4 complex with p-aminobenzamidine and Zn+2 ion (grey) (PDB code 2bdh)

Drag the structure with the mouse to rotate

References

  1. Bryant JW, Shariat-Madar Z. Human plasma kallikrein-kinin system: physiological and biochemical parameters. Cardiovasc Hematol Agents Med Chem. 2009 Jul;7(3):234-50. PMID:19689262
  2. Feener EP. Plasma kallikrein and diabetic macular edema. Curr Diab Rep. 2010 Aug;10(4):270-5. doi: 10.1007/s11892-010-0127-1. PMID:20535647 doi:http://dx.doi.org/10.1007/s11892-010-0127-1
  3. Pampalakis G, Sotiropoulou G. Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer. Biol Chem. 2006 Jun;387(6):773-82. PMID:16800739 doi:http://dx.doi.org/10.1515/BC.2006.097
  4. Cerqueira C, Samperio Ventayol P, Vogeley C, Schelhaas M. Kallikrein-8 Proteolytically Processes Human Papillomaviruses in the Extracellular Space To Facilitate Entry into Host Cells. J Virol. 2015 Jul;89(14):7038-52. doi: 10.1128/JVI.00234-15. Epub 2015 Apr 29. PMID:25926655 doi:http://dx.doi.org/10.1128/JVI.00234-15
  5. Debela M, Magdolen V, Grimminger V, Sommerhoff C, Messerschmidt A, Huber R, Friedrich R, Bode W, Goettig P. Crystal structures of human tissue kallikrein 4: activity modulation by a specific zinc binding site. J Mol Biol. 2006 Oct 6;362(5):1094-107. Epub 2006 Aug 3. PMID:16950394 doi:10.1016/j.jmb.2006.08.003

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