Kelch-like protein
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
The <scene name='70/706701/Cv/7'>interaction of Keap1 with Neh2 is through the first Glu in the latter's ETGE motif</scene><ref>PMID:16507366</ref>. <scene name='70/706701/Cv/8'>All interactions of Keap1 with Neh2</scene>. Water molecules shown as red spheres. | The <scene name='70/706701/Cv/7'>interaction of Keap1 with Neh2 is through the first Glu in the latter's ETGE motif</scene><ref>PMID:16507366</ref>. <scene name='70/706701/Cv/8'>All interactions of Keap1 with Neh2</scene>. Water molecules shown as red spheres. | ||
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| + | == 3D Structures of Kelch-like protein == | ||
| + | [[Kelch-like protein 3D structures]] | ||
</StructureSection> | </StructureSection> | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | |||
| - | *Kelch-like protein 1 | ||
| - | |||
| - | **[[4xmb]] – hKLHL1 Kelch domain + NRF2 activator - human <br /> | ||
| - | **[[5cgj]] – mKLHL1 Kelch domain + NRF2 activator - mouse <br /> | ||
*Kelch-like protein 2 | *Kelch-like protein 2 | ||
| - | **[[2xn4]] – hKLHL2 Kelch domain | + | **[[2xn4]] – hKLHL2 Kelch domain - human <br /> |
*Kelch-like protein 3 | *Kelch-like protein 3 | ||
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**[[2ppi]] – hKLHL16 BTB domain <br /> | **[[2ppi]] – hKLHL16 BTB domain <br /> | ||
| - | *Kelch-like protein | + | *Kelch-like protein 17 (actinfilin) |
| - | **[[1u6d]], [[1zgk]], [[4ifj]] – hKeap1 Kelch domain <br /> | + | **[[6hrl]] – hKLHL17 <br /> |
| - | **[[3zgd]] – hKeap1 Kelch domain (mutant) <br /> | + | |
| + | *Kelch-like protein 19 (kelch-like ECH-associated protein 1; Keap1)); domains: BTB 48-140; kelch 320-812 | ||
| + | |||
| + | **[[1u6d]], [[1zgk]], [[4ifj]], [[6rog]] – hKeap1 Kelch domain <br /> | ||
| + | **[[3zgd]], [[5wfl]] – hKeap1 Kelch domain (mutant) <br /> | ||
**[[4cxi]], [[4cxj]] – hKeap1 BTB domain (mutant) <br /> | **[[4cxi]], [[4cxj]] – hKeap1 BTB domain (mutant) <br /> | ||
**[[1x2j]] – mKeap1 Kelch domain <br /> | **[[1x2j]] – mKeap1 Kelch domain <br /> | ||
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*Keap1 complex with peptide | *Keap1 complex with peptide | ||
| + | **[[4ifl]], [[2flu]], [[3zgc]] – hKeap1 Kelch domain + NRF2 Neh2 peptide <br /> | ||
| + | **[[5wfv]], [[5wg1]] – hKeap1 Kelch domain (mutant) + NRF2 peptide <br /> | ||
| + | **[[6fmp]], [[6fmq]] – hKeap1 Kelch domain + peptide <br /> | ||
| + | **[[5f72]] – hKeap1 Kelch domain + antibody <br /> | ||
| + | **[[5x54]] – hKeap1 Kelch domain + tetrapeptide <br /> | ||
| + | **[[5nlb]] – hKLHL1 BTB+ 3-BOX domains + CUL-3 <br /> | ||
| + | **[[4xmb]] – hKLHL1 Kelch domain + NRF2 activator <br /> | ||
| + | **[[5cgj]] – mKLHL1 Kelch domain + NRF2 activator - mouse <br /> | ||
**[[1x2r]] – mKeap1 Kelch domain + NRF2 Neh2 peptide <br /> | **[[1x2r]] – mKeap1 Kelch domain + NRF2 Neh2 peptide <br /> | ||
**[[2z32]] – mKeap1 Kelch domain + prothymosin a peptide <br /> | **[[2z32]] – mKeap1 Kelch domain + prothymosin a peptide <br /> | ||
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**[[2dyh]] – mKeap1 Kelch domain + NRF2 residues 22-36 <br /> | **[[2dyh]] – mKeap1 Kelch domain + NRF2 residues 22-36 <br /> | ||
**[[3wn7]] – mKeap1 Kelch domain + NRF2 residues 17-51 <br /> | **[[3wn7]] – mKeap1 Kelch domain + NRF2 residues 17-51 <br /> | ||
| - | **[[4ifl]], [[2flu]], [[3zgc]] – hKeap1 Kelch domain + NRF2 Neh2 peptide <br /> | ||
| - | **[[5nlb]] – hKeap1 BTB+ 3-BOX domains + CUL-3 <br /> | ||
| - | **[[5f72]] – hKLHL1 Kelch domain + antibody <br /> | ||
| - | **[[5x54]] – hKLHL1 Kelch domain + tetrapeptide <br /> | ||
*Keap1 complex with small molecule | *Keap1 complex with small molecule | ||
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**[[4l7b]], [[4l7c]], [[4l7d]] [[4n1b]] – hKeap1 Kelch domain (mutant) + quinoline derivative <br /> | **[[4l7b]], [[4l7c]], [[4l7d]] [[4n1b]] – hKeap1 Kelch domain (mutant) + quinoline derivative <br /> | ||
**[[4in4]], [[4zy3]], [[5fnq]], [[5fnr]], [[5fns]], [[5fnt]], [[5fnu]], [[5fzj]], [[5fzn]] – hKeap1 Kelch domain + inhibitor <br /> | **[[4in4]], [[4zy3]], [[5fnq]], [[5fnr]], [[5fns]], [[5fnt]], [[5fnu]], [[5fzj]], [[5fzn]] – hKeap1 Kelch domain + inhibitor <br /> | ||
| - | **[[4iqk]], [[4n1b]] – hKeap1 Kelch domain (mutant) + inhibitor <br /> | + | **[[4iqk]], [[4n1b]], [[5wiy]], [[5whl]], [[5who]] – hKeap1 Kelch domain (mutant) + inhibitor <br /> |
**[[4cxt]] – hKeap1 BTB domain (mutant) + antagonist<br /> | **[[4cxt]] – hKeap1 BTB domain (mutant) + antagonist<br /> | ||
**[[5dad]], [[5daf]] – hKeap1 BTB domain + activator <br /> | **[[5dad]], [[5daf]] – hKeap1 BTB domain + activator <br /> | ||
| + | **[[5git]] – hKeap1 BTB domain + inhibitor <br /> | ||
| + | **[[6qmc]], [[6qmd]], [[6qme]], [[6qmj]], [[6qmk]] – mKeap1 Kelch domain + inhibitor <br /> | ||
| + | |||
| + | *Kelch-like protein 20 | ||
| + | |||
| + | **[[5yq4]] – hKLHL20 kelch domain <br /> | ||
| + | **[[6gy5]] – hKLHL20 kelch domain + DAPK1 peptide <br /> | ||
}} | }} | ||
Revision as of 09:51, 8 September 2019
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3D Structures of Kelch-like protein
Updated on 08-September-2019
References
- ↑ Dhanoa BS, Cogliati T, Satish AG, Bruford EA, Friedman JS. Update on the Kelch-like (KLHL) gene family. Hum Genomics. 2013 May 15;7:13. doi: 10.1186/1479-7364-7-13. PMID:23676014 doi:http://dx.doi.org/10.1186/1479-7364-7-13
- ↑ Padmanabhan B, Tong KI, Ohta T, Nakamura Y, Scharlock M, Ohtsuji M, Kang MI, Kobayashi A, Yokoyama S, Yamamoto M. Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. Mol Cell. 2006 Mar 3;21(5):689-700. PMID:16507366 doi:10.1016/j.molcel.2006.01.013
