Spindlin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 12: Line 12:
== Structural highlights ==
== Structural highlights ==
-
The crystal complex of SPIN1 and histone H3 peptide shows the <scene name='77/778344/Cv/2'>encapsulation of the histone trimethyllysine</scene> and <scene name='77/778344/Cv/3'>its Arg</scene> in hydrophobic pockets of SPIN1<ref>PMID:24589551</ref>.
+
The crystal complex of SPIN1 and histone H3 peptide shows the <scene name='77/778344/Cv/4'>encapsulation of the histone trimethyllysine</scene> and <scene name='77/778344/Cv/5'>its Arg</scene> in hydrophobic pockets of SPIN1<ref>PMID:24589551</ref>.
</StructureSection>
</StructureSection>
== 3D Structures of spindlin ==
== 3D Structures of spindlin ==

Revision as of 13:21, 12 September 2019

Human spindlin-1 (skyblue) complex with histone H3 peptide (wheat) containing trimethyl lysine, MPD, Mg+2 (green) and Cl- (green) ions (PDB code 4mzg)

Drag the structure with the mouse to rotate

3D Structures of spindlin

Updated on 12-September-2019

References

  1. ↑ Wang W, Chen Z, Mao Z, Zhang H, Ding X, Chen S, Zhang X, Xu R, Zhu B. Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes. EMBO Rep. 2011 Oct 28;12(11):1160-6. doi: 10.1038/embor.2011.184. PMID:21960006 doi:http://dx.doi.org/10.1038/embor.2011.184
  2. ↑ Franz H, Greschik H, Willmann D, Ozretic L, Jilg CA, Wardelmann E, Jung M, Buettner R, Schule R. The histone code reader SPIN1 controls RET signaling in liposarcoma. Oncotarget. 2015 Mar 10;6(7):4773-89. doi: 10.18632/oncotarget.3000. PMID:25749382 doi:http://dx.doi.org/10.18632/oncotarget.3000
  3. ↑ Su X, Zhu G, Ding X, Lee SY, Dou Y, Zhu B, Wu W, Li H. Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1. Genes Dev. 2014 Mar 15;28(6):622-36. doi: 10.1101/gad.233239.113. Epub 2014 Mar, 3. PMID:24589551 doi:http://dx.doi.org/10.1101/gad.233239.113

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Spindlin"
Personal tools