Squalene-hopene cyclase

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== Structural highlights ==
== Structural highlights ==
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The <scene name='59/591998/Cv/5'>active site of SHC binds the close substrate analog azosqualene</scene><ref>PMID:15113001</ref>. Water molecules shown as red spheres.
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The <scene name='59/591998/Cv/6'>active site of SHC binds the close substrate analog azosqualene</scene><ref>PMID:15113001</ref>. Water molecules are shown as red spheres.
</StructureSection>
</StructureSection>

Revision as of 13:23, 12 September 2019

Structure of squalene-hopene cyclase complex with 2-azasqualene and detergent (PDB code 1ump).

Drag the structure with the mouse to rotate

3D structures of squalene-hopene cyclase

Updated on 12-September-2019

References

  1. ↑ Hammer SC, Marjanovic A, Dominicus JM, Nestl BM, Hauer B. Squalene hopene cyclases are protonases for stereoselective Bronsted acid catalysis. Nat Chem Biol. 2015 Feb;11(2):121-6. doi: 10.1038/nchembio.1719. Epub 2014 Dec, 15. PMID:25503928 doi:http://dx.doi.org/10.1038/nchembio.1719
  2. ↑ Reinert DJ, Balliano G, Schulz GE. Conversion of squalene to the pentacarbocyclic hopene. Chem Biol. 2004 Jan;11(1):121-6. PMID:15113001 doi:http://dx.doi.org/10.1016/j.chembiol.2003.12.013

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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