Thymidine kinase
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
| - | The biological assembly of Thymidine kinase is <scene name='45/455455/Cv/ | + | The biological assembly of Thymidine kinase is <scene name='45/455455/Cv/5'>homotetramer</scene>. <scene name='45/455455/Cv/6'>Thymidine and phosphate are bound in the hydrophobic active site pocket of TK</scene><ref>PMID:17288553</ref>. Water molecules are shown as red spheres. |
</StructureSection> | </StructureSection> | ||
Revision as of 12:31, 23 September 2019
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3D Structures of thymidine kinase
Updated on 23-September-2019
References
- ↑ Perez-Perez MJ, Priego EM, Hernandez AI, Familiar O, Camarasa MJ, Negri A, Gago F, Balzarini J. Structure, physiological role, and specific inhibitors of human thymidine kinase 2 (TK2): present and future. Med Res Rev. 2008 Sep;28(5):797-820. doi: 10.1002/med.20124. PMID:18459168 doi:http://dx.doi.org/10.1002/med.20124
- ↑ He Q, Zhang P, Zou L, Li H, Wang X, Zhou S, Fornander T, Skog S. Concentration of thymidine kinase 1 in serum (S-TK1) is a more sensitive proliferation marker in human solid tumors than its activity. Oncol Rep. 2005 Oct;14(4):1013-9. PMID:16142366
- ↑ Saada A, Shaag A, Mandel H, Nevo Y, Eriksson S, Elpeleg O. Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy. Nat Genet. 2001 Nov;29(3):342-4. PMID:11687801 doi:http://dx.doi.org/10.1038/ng751
- ↑ Kosinska U, Carnrot C, Sandrini MP, Clausen AR, Wang L, Piskur J, Eriksson S, Eklund H. Structural studies of thymidine kinases from Bacillus anthracis and Bacillus cereus provide insights into quaternary structure and conformational changes upon substrate binding. FEBS J. 2007 Feb;274(3):727-37. PMID:17288553 doi:10.1111/j.1742-4658.2006.05617.x
