Thymidylate kinase
From Proteopedia
(Difference between revisions)
| Line 9: | Line 9: | ||
== Structural highlights == | == Structural highlights == | ||
The active site of TMK contains HIV prodrug azido-thymidine, ADP and Mg+2 ion<ref>PMID:11071809</ref>. | The active site of TMK contains HIV prodrug azido-thymidine, ADP and Mg+2 ion<ref>PMID:11071809</ref>. | ||
| - | *<scene name='54/542330/Cv/ | + | *<scene name='54/542330/Cv/6'>Azido-thymidine binding site</scene>. Water molecules are shown as red spheres. |
| - | *<scene name='54/542330/Cv/ | + | *<scene name='54/542330/Cv/7'>Mg coordination site</scene>. |
| - | *<scene name='54/542330/Cv/ | + | *<scene name='54/542330/Cv/8'>ATM binding site</scene>. |
| - | *<scene name='54/542330/Cv/ | + | *<scene name='54/542330/Cv/9'>Whole binding site</scene>. |
</StructureSection> | </StructureSection> | ||
== 3D Structures of thymidylate kinase == | == 3D Structures of thymidylate kinase == | ||
Revision as of 12:33, 23 September 2019
| |||||||||||
3D Structures of thymidylate kinase
Updated on 23-September-2019
References
- ↑ Cui Q, Shin WS, Luo Y, Tian J, Cui H, Yin D. Thymidylate kinase: an old topic brings new perspectives. Curr Med Chem. 2013;20(10):1286-305. PMID:23394555
- ↑ Wohrl BM, Loubiere L, Brundiers R, Goody RS, Klatzmann D, Konrad M. Expressing engineered thymidylate kinase variants in human cells to improve AZT phosphorylation and human immunodeficiency virus inhibition. J Gen Virol. 2005 Mar;86(Pt 3):757-64. PMID:15722537 doi:http://dx.doi.org/10.1099/vir.0.80529-0
- ↑ Martinez-Botella G, Breen JN, Duffy JE, Dumas J, Geng B, Gowers IK, Green OM, Guler S, Hentemann MF, Hernandez-Juan FA, Joseph-McCarthy D, Kawatkar SP, Larsen NA, Lazari O, Loch JT, Macritchie JA, McKenzie AR, Newman JV, Olivier NB, Otterson LG, Owens AP, Read J, Sheppard DW, Keating TA. Discovery of Selective and Potent Inhibitors of Gram-positive Bacterial Thymidylate Kinase (TMK). J Med Chem. 2012 Oct 8. PMID:23043329 doi:http://dx.doi.org/10.1021/jm3011806
- ↑ Ostermann N, Lavie A, Padiyar S, Brundiers R, Veit T, Reinstein J, Goody RS, Konrad M, Schlichting I. Potentiating AZT activation: structures of wild-type and mutant human thymidylate kinase suggest reasons for the mutants' improved kinetics with the HIV prodrug metabolite AZTMP. J Mol Biol. 2000 Nov 17;304(1):43-53. PMID:11071809 doi:10.1006/jmbi.2000.4175
