6hpi
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==NMR structure of the pro-inflammatory cytokine interleukin-36alpha== | |
| - | + | <StructureSection load='6hpi' size='340' side='right'caption='[[6hpi]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6hpi]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HPI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hpi OCA], [http://pdbe.org/6hpi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hpi RCSB], [http://www.ebi.ac.uk/pdbsum/6hpi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hpi ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IL36A_HUMAN IL36A_HUMAN]] Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by upregulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T-cell proliferation. May play a role in proinflammatory effects in the lung.<ref>PMID:14734551</ref> <ref>PMID:21881584</ref> <ref>PMID:21965679</ref> <ref>PMID:24829417</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Imhof, D]] | [[Category: Imhof, D]] | ||
[[Category: Ohlenschlaeger, O]] | [[Category: Ohlenschlaeger, O]] | ||
| + | [[Category: Cytokine]] | ||
| + | [[Category: Protein interleukin-1 superfamily beta-trefoil heme-binding]] | ||
Revision as of 10:19, 2 October 2019
NMR structure of the pro-inflammatory cytokine interleukin-36alpha
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