This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


6hpi

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 6hpi is ON HOLD until Sep 21 2020
+
==NMR structure of the pro-inflammatory cytokine interleukin-36alpha==
-
 
+
<StructureSection load='6hpi' size='340' side='right'caption='[[6hpi]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
-
Authors: Ohlenschlaeger, O., Imhof, D.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[6hpi]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HPI FirstGlance]. <br>
-
Description: NMR structure of the pro-inflammatory cytokine interleukin-36alpha
+
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hpi OCA], [http://pdbe.org/6hpi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hpi RCSB], [http://www.ebi.ac.uk/pdbsum/6hpi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hpi ProSAT]</span></td></tr>
-
[[Category: Unreleased Structures]]
+
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/IL36A_HUMAN IL36A_HUMAN]] Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by upregulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T-cell proliferation. May play a role in proinflammatory effects in the lung.<ref>PMID:14734551</ref> <ref>PMID:21881584</ref> <ref>PMID:21965679</ref> <ref>PMID:24829417</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Imhof, D]]
[[Category: Imhof, D]]
[[Category: Ohlenschlaeger, O]]
[[Category: Ohlenschlaeger, O]]
 +
[[Category: Cytokine]]
 +
[[Category: Protein interleukin-1 superfamily beta-trefoil heme-binding]]

Revision as of 10:19, 2 October 2019

NMR structure of the pro-inflammatory cytokine interleukin-36alpha

PDB ID 6hpi

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6hpi"
Personal tools