6jpv
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structural analysis of AIMP2-DX2 and HSP70 interaction== | |
| - | + | <StructureSection load='6jpv' size='340' side='right'caption='[[6jpv]], [[Resolution|resolution]] 2.15Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6jpv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JPV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JPV FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jpv OCA], [http://pdbe.org/6jpv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jpv RCSB], [http://www.ebi.ac.uk/pdbsum/6jpv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jpv ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HS71A_HUMAN HS71A_HUMAN]] In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223).<ref>PMID:16537599</ref> <ref>PMID:22528486</ref> <ref>PMID:23973223</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cho, H Y]] | ||
| + | [[Category: Jeon, Y H]] | ||
| + | [[Category: Son, S Y]] | ||
| + | [[Category: Aimp2-dx2]] | ||
| + | [[Category: Chaperone]] | ||
| + | [[Category: Hsp70]] | ||
| + | [[Category: Substrate binding domain]] | ||
Revision as of 10:21, 2 October 2019
Structural analysis of AIMP2-DX2 and HSP70 interaction
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