6jr1
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the human nucleosome phased with 16 selenium atoms== | |
| - | + | <StructureSection load='6jr1' size='340' side='right'caption='[[6jr1]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6jr1]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JR1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JR1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jr1 OCA], [http://pdbe.org/6jr1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jr1 RCSB], [http://www.ebi.ac.uk/pdbsum/6jr1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jr1 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Horikoshi, N]] | ||
| + | [[Category: Kagawa, W]] | ||
| + | [[Category: Kujirai, T]] | ||
| + | [[Category: Kurumizaka, H]] | ||
| + | [[Category: Saotome, M]] | ||
| + | [[Category: Urano, K]] | ||
| + | [[Category: Yuzurihara, H]] | ||
| + | [[Category: Chromatin]] | ||
| + | [[Category: Gene regulation]] | ||
| + | [[Category: Gene regulation-dna complex]] | ||
| + | [[Category: Histone]] | ||
| + | [[Category: Nucleosome]] | ||
| + | [[Category: Sad phasing]] | ||
| + | [[Category: Selenomethionine]] | ||
Revision as of 10:22, 2 October 2019
Crystal structure of the human nucleosome phased with 16 selenium atoms
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