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| - | '''Unreleased structure''' | |
| | | | |
| - | The entry 6qsk is ON HOLD
| + | ==Crystal structure of a nucleotide sugar transporter with bound nucleotide monophosphate.== |
| - | | + | <StructureSection load='6qsk' size='340' side='right'caption='[[6qsk]], [[Resolution|resolution]] 3.39Å' scene=''> |
| - | Authors: Newstead, S., Parker, J.L.
| + | == Structural highlights == |
| - | | + | <table><tr><td colspan='2'>[[6qsk]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QSK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QSK FirstGlance]. <br> |
| - | Description: Crystal structure of a nucleotide sugar transporter with bound nucleotide monophosphate.
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr> |
| - | [[Category: Unreleased Structures]] | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5oge|5oge]], [[5ogk|5ogk]]</td></tr> |
| | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qsk OCA], [http://pdbe.org/6qsk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qsk RCSB], [http://www.ebi.ac.uk/pdbsum/6qsk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qsk ProSAT]</span></td></tr> |
| | + | </table> |
| | + | == Function == |
| | + | [[http://www.uniprot.org/uniprot/GMT1_YEAST GMT1_YEAST]] Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen. Defective copy causes severe glycosylation defect and abnormal retention of soluble endoplasmic reticulum proteins. Involved in vanadate sensitivity.<ref>PMID:10570930</ref> <ref>PMID:11067855</ref> <ref>PMID:12478588</ref> <ref>PMID:15494368</ref> <ref>PMID:2014241</ref> <ref>PMID:2137555</ref> <ref>PMID:7672592</ref> <ref>PMID:7877969</ref> <ref>PMID:8632002</ref> <ref>PMID:9184829</ref> <ref>PMID:9335583</ref> <ref>PMID:9395539</ref> |
| | + | == References == |
| | + | <references/> |
| | + | __TOC__ |
| | + | </StructureSection> |
| | + | [[Category: Large Structures]] |
| | [[Category: Newstead, S]] | | [[Category: Newstead, S]] |
| - | [[Category: Parker, J.L]] | + | [[Category: Parker, J L]] |
| | + | [[Category: Gdp-mannose transport]] |
| | + | [[Category: Glycosylation]] |
| | + | [[Category: Golgi transporter]] |
| | + | [[Category: Membrane protein]] |
| | + | [[Category: Slc35]] |
| Structural highlights
Function
[GMT1_YEAST] Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen. Defective copy causes severe glycosylation defect and abnormal retention of soluble endoplasmic reticulum proteins. Involved in vanadate sensitivity.[1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11] [12]
References
- ↑ Abe M, Hashimoto H, Yoda K. Molecular characterization of Vig4/Vrg4 GDP-mannose transporter of the yeast Saccharomyces cerevisiae. FEBS Lett. 1999 Sep 24;458(3):309-12. PMID:10570930
- ↑ Gao XD, Nishikawa A, Dean N. Identification of a conserved motif in the yeast golgi GDP-mannose transporter required for binding to nucleotide sugar. J Biol Chem. 2001 Feb 9;276(6):4424-32. Epub 2000 Nov 6. PMID:11067855 doi:http://dx.doi.org/10.1074/jbc.M009114200
- ↑ Hashimoto H, Abe M, Hirata A, Noda Y, Adachi H, Yoda K. Progression of the stacked Golgi compartments in the yeast Saccharomyces cerevisiae by overproduction of GDP-mannose transporter. Yeast. 2002 Dec;19(16):1413-24. PMID:12478588 doi:http://dx.doi.org/10.1002/yea.925
- ↑ Abe M, Noda Y, Adachi H, Yoda K. Localization of GDP-mannose transporter in the Golgi requires retrieval to the endoplasmic reticulum depending on its cytoplasmic tail and coatomer. J Cell Sci. 2004 Nov 1;117(Pt 23):5687-96. Epub 2004 Oct 19. PMID:15494368 doi:http://dx.doi.org/10.1242/jcs.01491
- ↑ Ballou L, Hitzeman RA, Lewis MS, Ballou CE. Vanadate-resistant yeast mutants are defective in protein glycosylation. Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3209-12. PMID:2014241
- ↑ Kanik-Ennulat C, Neff N. Vanadate-resistant mutants of Saccharomyces cerevisiae show alterations in protein phosphorylation and growth control. Mol Cell Biol. 1990 Mar;10(3):898-909. PMID:2137555
- ↑ Kanik-Ennulat C, Montalvo E, Neff N. Sodium orthovanadate-resistant mutants of Saccharomyces cerevisiae show defects in Golgi-mediated protein glycosylation, sporulation and detergent resistance. Genetics. 1995 Jul;140(3):933-43. PMID:7672592
- ↑ Dean N. Yeast glycosylation mutants are sensitive to aminoglycosides. Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1287-91. PMID:7877969
- ↑ Poster JB, Dean N. The yeast VRG4 gene is required for normal Golgi functions and defines a new family of related genes. J Biol Chem. 1996 Feb 16;271(7):3837-45. PMID:8632002
- ↑ Manas P, Olivero I, Avalos M, Hernandez LM. Isolation of new nonconditional Saccharomyces cerevisiae mutants defective in asparagine-linked glycosylation. Glycobiology. 1997 Jun;7(4):487-97. PMID:9184829
- ↑ Mondesert G, Clarke DJ, Reed SI. Identification of genes controlling growth polarity in the budding yeast Saccharomyces cerevisiae: a possible role of N-glycosylation and involvement of the exocyst complex. Genetics. 1997 Oct;147(2):421-34. PMID:9335583
- ↑ Dean N, Zhang YB, Poster JB. The VRG4 gene is required for GDP-mannose transport into the lumen of the Golgi in the yeast, Saccharomyces cerevisiae. J Biol Chem. 1997 Dec 12;272(50):31908-14. PMID:9395539
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