6rnu
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==BCL-XL in a complex with a covalent small molecule inhibitor== | |
| - | + | <StructureSection load='6rnu' size='340' side='right'caption='[[6rnu]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6rnu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RNU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RNU FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=KBH:4-(4-fluorophenyl)-3-fluorosulfonyl-benzoic+acid'>KBH</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rnu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rnu OCA], [http://pdbe.org/6rnu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rnu RCSB], [http://www.ebi.ac.uk/pdbsum/6rnu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rnu ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Hargreaves, D]] | [[Category: Hargreaves, D]] | ||
| + | [[Category: Bcl-xl]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 10:40, 2 October 2019
BCL-XL in a complex with a covalent small molecule inhibitor
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