RNA Polymerase II

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== RNAP II ==
== RNAP II ==
<StructureSection load='1i6h' size='340' side='right' caption='RNA Polymerase II''>
<StructureSection load='1i6h' size='340' side='right' caption='RNA Polymerase II''>
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This is a default text for your page '''RNA Polymerase II'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
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== Structural Components ==
== Structural Components ==
The <scene name='82/824648/Clamp/2'>clamp</scene> swings to trap the DNA in the cleft. Further along, the <scene name='82/824648/Wall/1'>wall</scene> sends the DNA template through the cleft in approximately a 90° turn. Both the clamp and wall are parts of the Rpb2 subunit. Further along in the process, the <scene name='82/824648/Rudder/1'>rudder</scene> separates the newly synthesized RNA strand from the DNA template. The DNA reforms into a double helix as it leaves RNA pol II.
The <scene name='82/824648/Clamp/2'>clamp</scene> swings to trap the DNA in the cleft. Further along, the <scene name='82/824648/Wall/1'>wall</scene> sends the DNA template through the cleft in approximately a 90° turn. Both the clamp and wall are parts of the Rpb2 subunit. Further along in the process, the <scene name='82/824648/Rudder/1'>rudder</scene> separates the newly synthesized RNA strand from the DNA template. The DNA reforms into a double helix as it leaves RNA pol II.

Revision as of 19:32, 6 October 2019

Contents

RNAP II

PDB ID 1i6h

Drag the structure with the mouse to rotate

References

Bushnell, D. A.; Westover, K. D.; Davis, R. E.; Kornberg, R. D. Structural Basis of Transcription: An RNA Polymerase II-TFIIB Cocrystal at 4.5 Angstroms. Science. 2004, 303, 983-988 Cramer, P.; Bushnell, D. A.; Kornberg, R. D. Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution. Science. 2001, 292, 1863-1876 Uzman, A.; Voet, D. Student companion Fundamentals of biochemistry: life at the molecular level, 4th ed., Donald Voet, Judith G. Voet, Charlotte W. Pratt; John Wiley & amp; Sons, 2012. Evans, D. A.; Fitch, D. M.; Smith, T. E.; Cee, V. J. Application of Complex Aldol Reactions to the Total Synthesis of Phorboxazole B. J. Am. Chem. Soc. 2000, 122, 10033-10046.

Notes

From structural components: Bridge: Depicted: [PDB: 1I6H: 810-845.a] Wall: Depicted: [PDB: 1R5U: 853-919.b; 933-972.b] Clamp: Depicted: [PDB: 1R5U: 3-345.a; 1395-1435.a; 1158-1124.b] Rudder: Depicted: [PDB: 5VVR: 306-321.a]


Content Donators

This page was created as a final project for the Advanced Biochemistry course at Wabash College during the Fall of 2019. This page was reviewed by Dr. Wally Novak of Wabash College.

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