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Publication Abstract from PubMed

Numerous applications of metal ion-mediated base pairs (metallo-base pairs) to nucleic acid-based nanodevices and genetic code expansion have extensively been studied. Many of these metallo-base pairs are formed in DNA and RNA duplexes containing Watson-Crick base pairs. Recently, a crystal structure of a metal-DNA nanowires with uninterrupted one-dimensional silver array has been reported. Herein, we have determined a crystal structure of a novel DNA helical wire containing Hg(II)-mediated T:T and T:G base pairs and water-mediated C:C base pairs. The Hg-DNA wire contains no Watson-Crick base pair. The crystals of the Hg-DNA wire, the first DNA wire structure driven by Hg(II) ions, were obtained by mixing a short oligonucleotide d(TTTGC) and Hg(II) ions. This study demonstrates potentials of metallo-DNA to form various structural components which can be used for functional nanodevices.

Novel DNA helical wire containing Hg(II) mediated T:T and T:G pairs.,Ono A, Kanazawa H, Ito H, Goto M, Nakamura K, Saneyoshi H, Kondo J Angew Chem Int Ed Engl. 2019 Sep 10. doi: 10.1002/anie.201910029. PMID:31507027^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.