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6jh0

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m (Protected "6jh0" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6jh0 is ON HOLD
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==Crystal structure of cISG15/NS1B complex==
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<StructureSection load='6jh0' size='340' side='right'caption='[[6jh0]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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Authors: Jiang, Y.N., Wang, X.Q.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6jh0]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JH0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JH0 FirstGlance]. <br>
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Description: Crystal structure of cISG15/NS1B complex
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jh0 OCA], [http://pdbe.org/6jh0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jh0 RCSB], [http://www.ebi.ac.uk/pdbsum/6jh0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jh0 ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Wang, X.Q]]
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== Function ==
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[[Category: Jiang, Y.N]]
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[[http://www.uniprot.org/uniprot/NS1_INBLE NS1_INBLE]] Binds and inhibits the ubiquitin-like protein G1P2/ISG15, which is an early antiviral protein. Inhibits IRF-3 nuclear translocation and activation. Inhibits IFN-beta promoter activation; this inhibition is not dsRNA-binding dependent Prevents EIF2AK2/PKR activation, either by binding double strand RNA or by interacting directly with EIF2AK2/PKR. Also binds poly(A) and U6 snRNA. Suppresses the RNA silencing-based antiviral response in Drosophila cells.<ref>PMID:15479798</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Jiang, Y N]]
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[[Category: Wang, X Q]]
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[[Category: Antiviral]]
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[[Category: Antiviral protein]]
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[[Category: Complex]]

Revision as of 05:51, 16 October 2019

Crystal structure of cISG15/NS1B complex

PDB ID 6jh0

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OCA

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