6r75

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m (Protected "6r75" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6r75 is ON HOLD
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==Crystal structure of human Ube2T E54R mutant==
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<StructureSection load='6r75' size='340' side='right'caption='[[6r75]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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Authors: Chaugule, V.K., Rennie, M.L., Walden, H.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6r75]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R75 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R75 FirstGlance]. <br>
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Description: Crystal structure of human Ube2T E54R mutant
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</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/E2_ubiquitin-conjugating_enzyme E2 ubiquitin-conjugating enzyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.2.23 2.3.2.23] </span></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r75 OCA], [http://pdbe.org/6r75 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r75 RCSB], [http://www.ebi.ac.uk/pdbsum/6r75 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r75 ProSAT]</span></td></tr>
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[[Category: Chaugule, V.K]]
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</table>
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[[Category: Rennie, M.L]]
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== Function ==
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[[http://www.uniprot.org/uniprot/UBE2T_HUMAN UBE2T_HUMAN]] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination.<ref>PMID:16916645</ref> <ref>PMID:17938197</ref> <ref>PMID:19111657</ref> <ref>PMID:19887602</ref> <ref>PMID:19589784</ref> <ref>PMID:20061386</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: E2 ubiquitin-conjugating enzyme]]
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[[Category: Large Structures]]
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[[Category: Arkinson, C]]
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[[Category: Chaugule, V K]]
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[[Category: Kamarainen, O]]
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[[Category: Rennie, M L]]
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[[Category: Toth, R]]
[[Category: Walden, H]]
[[Category: Walden, H]]
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[[Category: Allostery]]
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[[Category: Dna repair]]
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[[Category: E2]]
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[[Category: Ligase]]
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[[Category: Ubiquitination]]

Revision as of 05:59, 16 October 2019

Crystal structure of human Ube2T E54R mutant

PDB ID 6r75

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OCA

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