This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6r75
From Proteopedia
(Difference between revisions)
m (Protected "6r75" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human Ube2T E54R mutant== | |
| - | + | <StructureSection load='6r75' size='340' side='right'caption='[[6r75]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6r75]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R75 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R75 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/E2_ubiquitin-conjugating_enzyme E2 ubiquitin-conjugating enzyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.2.23 2.3.2.23] </span></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r75 OCA], [http://pdbe.org/6r75 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r75 RCSB], [http://www.ebi.ac.uk/pdbsum/6r75 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r75 ProSAT]</span></td></tr> |
| - | [[Category: Chaugule, V | + | </table> |
| - | [[Category: Rennie, M | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/UBE2T_HUMAN UBE2T_HUMAN]] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination.<ref>PMID:16916645</ref> <ref>PMID:17938197</ref> <ref>PMID:19111657</ref> <ref>PMID:19887602</ref> <ref>PMID:19589784</ref> <ref>PMID:20061386</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: E2 ubiquitin-conjugating enzyme]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arkinson, C]] | ||
| + | [[Category: Chaugule, V K]] | ||
| + | [[Category: Kamarainen, O]] | ||
| + | [[Category: Rennie, M L]] | ||
| + | [[Category: Toth, R]] | ||
[[Category: Walden, H]] | [[Category: Walden, H]] | ||
| + | [[Category: Allostery]] | ||
| + | [[Category: Dna repair]] | ||
| + | [[Category: E2]] | ||
| + | [[Category: Ligase]] | ||
| + | [[Category: Ubiquitination]] | ||
Revision as of 05:59, 16 October 2019
Crystal structure of human Ube2T E54R mutant
| |||||||||||
