Kinesin

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<scene name='41/410296/Cv/14'>Mg coordination site</scene>.
<scene name='41/410296/Cv/14'>Mg coordination site</scene>.
 +
== 3D Structures of Kinesin ==
 +
[[Kinesin 3D Structures]]
 +
</StructureSection>
</StructureSection>
== 3D Structures of Kinesin ==
== 3D Structures of Kinesin ==
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*Kinesin heavy chain
*Kinesin heavy chain
-
**[[2zfi]], [[2zfj]], [[2zfk]], [[2zfl]], [[2zfm]] – mKIF1A – mouse<br />
 
**[[4ejq]], [[4egx]] - hKIF1A FHA domain - human<br />
**[[4ejq]], [[4egx]] - hKIF1A FHA domain - human<br />
-
**[[3wrd]] – mKIF5C<br />
+
**[[1bg2]] – hKIF MD<br />
-
**[[2vvg]] – KIF2 MD – ''Giardia intestinalis''<br />
+
**[[5lt3]], [[5lt4]], [[5lt2]], [[5lt0]], [[5lt1]] – hKIF1 MD (mutant) <br />
**[[2g1l]] - hKIF1C FHA domain<br />
**[[2g1l]] - hKIF1C FHA domain<br />
**[[5wdh]] – hKIF1C MD<br />
**[[5wdh]] – hKIF1C MD<br />
-
**[[2owm]] – NcKIF1C MD – ''Neurospora crassa''<br />
+
**[[2rep]] – hKIFC1 MD<br />
-
**[[1goj]] – NcKIF MD<br />
+
-
**[[6nje]] – hKIF22 MD<br />
+
-
**[[3b6u]], [[3b6v]] – hKIF3B MD<br />
+
-
**[[5wdh]] – hKIFC1 MD<br />
+
**[[2eh0]] - hKIF1B FHA domain – NMR<br />
**[[2eh0]] - hKIF1B FHA domain – NMR<br />
-
**[[5d3a]] – hKIF21A coiled coil domain residues 938-1017 <br />
+
**[[2heh]], [[4ubf]], [[5y05]] – hKIF2C<br />
-
**[[2edu]] – hKIF22 C-terminal – NMR<br />
+
**[[3b6u]], [[3b6v]] – hKIF3B MD<br />
**[[4a14]] – hKIF7 MD <br />
**[[4a14]] – hKIF7 MD <br />
**[[2xt3]] – hKIF7 MD (mutant)<br />
**[[2xt3]] – hKIF7 MD (mutant)<br />
 +
**[[3j2u]] – hKIF10A head domain – Cryo EM<br />
 +
**[[2cow]] – hKIF13B CAP-gly domain – NMR<br />
**[[4bn2]] – hKIF15 MD<br />
**[[4bn2]] – hKIF15 MD<br />
**[[2v14]] – hKIF16B<br />
**[[2v14]] – hKIF16B<br />
-
**[[2heh]], [[4ubf]], [[5y05]] – hKIF2C<br />
+
**[[5d3a]] – hKIF21A coiled coil domain 938-1017 <br />
-
**[[3j2u]] – hKIF10A head domain – Cryo EM<br />
+
**[[2edu]] – hKIF22 C-terminal – NMR<br />
 +
**[[3bfn]] – hKIF22 MD<br />
 +
**[[2zfi]], [[2zfj]], [[2zfk]], [[2zfl]], [[2zfm]] – mKIF1A – mouse<br />
 +
**[[6ign]], [[6igv]] – mKIF5B coiled coil domain 444-566 <br />
 +
**[[3wrd]] – mKIF5C<br />
**[[5djo]] – mKIF13A CC1-FHA domain <br />
**[[5djo]] – mKIF13A CC1-FHA domain <br />
**[[5djn]] – mKIF13A coiled-coil domain (mutant)<br />
**[[5djn]] – mKIF13A coiled-coil domain (mutant)<br />
-
**[[2cow]] – hKIF13B CAP-gly domain – NMR<br />
 
-
**[[1bg2]] – hKIF MD<br />
 
-
**[[5lt3]], [[5lt4]], [[5lt2]], [[5lt0]], [[5lt1]] – hKIF MD (mutant) <br />
 
**[[3kin]], [[2kin]] – rKIF MD - rat<br />
**[[3kin]], [[2kin]] – rKIF MD - rat<br />
 +
**[[6a1z]] – rKIF13B<br />
 +
**[[6a20]] – rKIF13B (mutant)<br />
**[[1ry6]] – KIF MD – ''Plasmodium falciparum''<br />
**[[1ry6]] – KIF MD – ''Plasmodium falciparum''<br />
**[[2ncd]], [[1cz7]] – DmKIF MD non-claret disjuctional (NCD) dimer – ''Drosophila melanogaster'' <br />
**[[2ncd]], [[1cz7]] – DmKIF MD non-claret disjuctional (NCD) dimer – ''Drosophila melanogaster'' <br />
**[[2y5w]], [[2y65]] - DmKIF MD<br />
**[[2y5w]], [[2y65]] - DmKIF MD<br />
 +
**[[2vvg]] – KIF2 MD – ''Giardia intestinalis''<br />
 +
**[[2owm]] – NcKIF1C MD – ''Neurospora crassa''<br />
 +
**[[1goj]] – NcKIF MD<br />
*''Kinesin heavy chain complex with nucleotide''
*''Kinesin heavy chain complex with nucleotide''
-
**[[3gbj]] – hKIF13B MD+ADP – human<br />
+
**[[2gry]] – hKIF2+ADP<br />
 +
**[[2h58]], [[5wde]] – hKIFC3+ADP<br />
 +
**[[3nwn]] – hKIF9+ADP<br />
 +
**[[3gbj]] – hKIF13B MD+ADP <br />
 +
**[[2cjo]] – hKIF13+inhibitor 30<br />
**[[1vfv]], [[1vfw]] – mKIF1A MD+Mg-AMPPNP<br />
**[[1vfv]], [[1vfw]] – mKIF1A MD+Mg-AMPPNP<br />
**[[1vfx]] - mKIF1A MD+ADP-Mg-AlFx<br />
**[[1vfx]] - mKIF1A MD+ADP-Mg-AlFx<br />
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**[[5gsy]] – mKIF19A MD + GDP<br />
**[[5gsy]] – mKIF19A MD + GDP<br />
**[[5gsz]] – mKIF19A MD + ADP<br />
**[[5gsz]] – mKIF19A MD + ADP<br />
-
**[[2cjo]] – hKIF13+inhibitor 30<br />
 
-
**[[3nwn]] – hKIF9+ADP<br />
 
-
**[[5wde]] – hKIFC3+ADP<br />
 
-
**[[2gry]] – hKIF2+ADP<br />
 
**[[3uyq]] – pKIF1A head+AMPPNP – pig<br />
**[[3uyq]] – pKIF1A head+AMPPNP – pig<br />
**[[2hxh]] - pKIF1A head+ADP<br />
**[[2hxh]] - pKIF1A head+ADP<br />
**[[2hxf]] - pKIF1A head+AMPPNP<br />
**[[2hxf]] - pKIF1A head+AMPPNP<br />
 +
*''Kinesin heavy chain complex with protein''
*''Kinesin heavy chain complex with protein''
-
**[[2wbe]] – cKIF MD+FNL+Tubulin +AMPPNP – cow <br />
+
**[[4hna]], [[4lnu]] – hKIF1 + Tubulin + designed ankyrin repeat protein + Mg-ADP + GDP + GTP + AlF4<br />
-
**[[1ia0]] – KIF1A MD+Tubulin +ATP - pig<br />
+
**[[4uxy]] – hKIF1 MD + Tubulin + GDP + GTP – Cryo EM<br />
-
**[[3edl]] – cKIF MD+ Tubulin – Cryo EM<br />
+
-
**[[4hna]], [[4lnu]] – hKIF1 + Tubulin + designed ankyrin repeat protein + Mg-ADP + GDP + GTP + AlF4<br />
+
-
**[[4uxy]] – hKIF1 MD + Tubulin + GDP + GTP – Cryo EM<br />
+
**[[4uy0]] – hKIF1 MD + Tubulin + GDP + GTP + ADP – Cryo EM<br />
**[[4uy0]] – hKIF1 MD + Tubulin + GDP + GTP + ADP – Cryo EM<br />
-
**[[2p4n]] – hKIF+ Tubulin – EM docking<br />
+
**[[2p4n]] – hKIF+ Tubulin – EM docking<br />
 +
**[[1mkj]] – hKIF MD+docked FNL<br />
**[[5mio]] – hKIF2C MD + Tubulin <br />
**[[5mio]] – hKIF2C MD + Tubulin <br />
-
**[[1mkj]] – hKIF MD+docked FNL<br />
+
**[[3fm8]] – hKIF13B FHA domain + centaurin-alpha-1<br />
-
**[[3fm8]] – hKIF13B FHA domain + centaurin-α-1<br />
+
**[[3md8]] – hKIF13B FHA domain + centaurin-alpha-1 + IP4<br />
-
**[[3md8]] – hKIF13B FHA domain + centaurin-α-1 + IP4<br />
+
**[[3vhx]] – hKIF23 794-911 + ADP-ribosylation factor 6 <br />
**[[3vhx]] – hKIF23 794-911 + ADP-ribosylation factor 6 <br />
-
**[[1n6m]] – DmKIF MD+FNL<br />
+
**[[2wbe]] – cKIF MD+FNL+Tubulin +AMPPNP – bovine <br />
 +
**[[3edl]] – cKIF MD+ Tubulin – EM<br />
 +
**[[1ia0]] – pKIF1A MD+Tubulin +ATP <br />
**[[4atx]] - rKIF MD+ Tubulin – Cryo EM<br />
**[[4atx]] - rKIF MD+ Tubulin – Cryo EM<br />
**[[3j6h]] – mKIF5C MD+Mg-GTP + G2P + tubulin <br />
**[[3j6h]] – mKIF5C MD+Mg-GTP + G2P + tubulin <br />
-
**[[3j8x]], [[3j8y]] – mKIF5C MD+ GTP + GDP + tubulin <br />
+
**[[3j8x]], [[3j8y]] – mKIF5C MD+ GTP + GDP + tubulin<br />
**[[5nd3]] – mKIF20A MD + tubulin <br />
**[[5nd3]] – mKIF20A MD + tubulin <br />
**[[5nd2]], [[5nd4]] – mKIF20A MD + tubulin + ADP <br />
**[[5nd2]], [[5nd4]] – mKIF20A MD + tubulin + ADP <br />
**[[5nd7]] – mKIF20A MD + tubulin + AMPPNP <br />
**[[5nd7]] – mKIF20A MD + tubulin + AMPPNP <br />
**[[5lef]] – mKIF20A residues 603-665 + RAB-6 <br />
**[[5lef]] – mKIF20A residues 603-665 + RAB-6 <br />
 +
**[[1n6m]] – DmKIF MD+FNL<br />
*Kinesin light chain (KLC)
*Kinesin light chain (KLC)
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**[[3edt]] – hKLC2<br />
**[[3edt]] – hKLC2<br />
**[[3ceq]], [[3nf1]] – hKLC2 TPR domain<br />
**[[3ceq]], [[3nf1]] – hKLC2 TPR domain<br />
-
**[[5ojf]] – mKLC2 TPR domain <br />
+
**[[6f9i]] – hKLC2 + clcytenin peptide <br />
-
**[[3zfw]], [[5fjy]] - mKLC2 TPR domain + peptide<br />
+
**[[6fv0]] – mKLC1 TPR domain + nanobody<br />
**[[6fv0]] – mKLC1 TPR domain + nanobody<br />
 +
**[[5ojf]] – mKLC2 TPR domain <br />
 +
**[[3zfw]], [[5fjy]], [[6ejn]] - mKLC2 TPR domain + peptide<br />
*Kinesin-3 motor domain
*Kinesin-3 motor domain
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**[[4pxt]], [[4pxu]] – DmKIF (mutant)<br />
**[[4pxt]], [[4pxu]] – DmKIF (mutant)<br />
**[[5m5i]], [[5m5l]], [[5m5m]], [[5m5n]], [[5m5o]] – KIF + tubulin + GDP + GTP + ANP + taxol – fission yeast – Cryo EM<br />
**[[5m5i]], [[5m5l]], [[5m5m]], [[5m5n]], [[5m5o]] – KIF + tubulin + GDP + GTP + ANP + taxol – fission yeast – Cryo EM<br />
-
**[[5mm4]] – KIF + tubulin + GDP + GTP + ANP + taxol – Ustilago maydis – Cryo EM<br />
+
**[[5mm4]], [[5mm7]] – KIF + tubulin + GDP + GTP + ANP + taxol – Ustilago maydis – Cryo EM<br />
*Kinesin-6
*Kinesin-6
-
**[[5x3e]] - KLP MD - Caenorhabditis elegans<br />
+
**[[5x3e]] - KLP MD - ''Caenorhabditis elegans''<br />
*Kinesin-8
*Kinesin-8

Revision as of 08:38, 17 October 2019

KIF1A Motor Domain complex with ADP and Mg+2 ion (green), 2zfi

Drag the structure with the mouse to rotate

3D Structures of Kinesin

Updated on 17-October-2019


References

  1. ↑ Hirokawa N, Noda Y, Tanaka Y, Niwa S. Kinesin superfamily motor proteins and intracellular transport. Nat Rev Mol Cell Biol. 2009 Oct;10(10):682-96. doi: 10.1038/nrm2774. PMID:19773780 doi:http://dx.doi.org/10.1038/nrm2774
  2. ↑ Ebbing B, Mann K, Starosta A, Jaud J, Schols L, Schule R, Woehlke G. Effect of spastic paraplegia mutations in KIF5A kinesin on transport activity. Hum Mol Genet. 2008 May 1;17(9):1245-52. doi: 10.1093/hmg/ddn014. Epub 2008 Jan, 18. PMID:18203753 doi:http://dx.doi.org/10.1093/hmg/ddn014
  3. ↑ Hirokawa N, Takemura R. Biochemical and molecular characterization of diseases linked to motor proteins. Trends Biochem Sci. 2003 Oct;28(10):558-65. PMID:14559185 doi:http://dx.doi.org/10.1016/j.tibs.2003.08.006
  4. ↑ Grosch M, Gruner B, Spranger S, Stutz AM, Rausch T, Korbel JO, Seelow D, Nurnberg P, Sticht H, Lausch E, Zabel B, Winterpacht A, Tagariello A. Identification of a Ninein (NIN) mutation in a family with spondyloepimetaphyseal dysplasia with joint laxity (leptodactylic type)-like phenotype. Matrix Biol. 2013 Oct-Nov;32(7-8):387-92. doi: 10.1016/j.matbio.2013.05.001. Epub, 2013 May 9. PMID:23665482 doi:http://dx.doi.org/10.1016/j.matbio.2013.05.001
  5. ↑ Nitta R, Okada Y, Hirokawa N. Structural model for strain-dependent microtubule activation of Mg-ADP release from kinesin. Nat Struct Mol Biol. 2008 Oct;15(10):1067-75. Epub 2008 Sep 21. PMID:18806800 doi:10.1038/nsmb.1487
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