Lactate Dehydrogenase

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==3D structures of lactate dehydrogenase==
==3D structures of lactate dehydrogenase==
[[Lactate dehydrogenase 3D structures]]
[[Lactate dehydrogenase 3D structures]]
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</StructureSection>
</StructureSection>
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==3D structures of lactate dehydrogenase==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*L-LDH
 
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**[[4l4r]], [[4ojn]] – hLDH A chain – human<br />
 
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**[[2ldx]] – C4-LDH - mouse<br />
 
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**[[5k0z]] – LDH B chain – chicken<br />
 
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**[[2e37]], [[2v6m]] – TtL-LDH – ''Thermus thermophilus''<BR />
 
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**[[3zzn]], [[4a73]]– TtL-LDH (mutant) <BR />
 
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**[[2x8l]], [[1ceq]] – PfL-LDH – ''Plasmodium falciparum''<BR />
 
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**[[2zqy]], [[2zqz]], [[1llc]] – LcL-LDH – ''Lactobacillus casei''<BR />
 
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**[[6j9s]] - LcL-LDH (mutant)<br />
 
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**[[3d0o]] - SaL-LDH – ''Staphylococcus aureus''<BR />
 
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**[[2v65]] - L-LDH A chain – ''Champsocephalus gunnari''<BR />
 
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**[[2v6b]] – L-LDH – ''Deinococcus radiodurans''<BR />
 
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**[[4nd5]] – CpLDH – ''Cryptosporidium parvum''<BR />
 
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**[[1sov]], [[1pze]] - TgL-LDH – ''Toxoplasma gondii''<BR />
 
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**[[1v6a]] – L-LDH A chain – ''Cyprinus carpio''<BR />
 
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**[[1y6j]] – L-LDH – ''Clostridium thermocellum''<BR />
 
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**[[1ldb]] - GsL-LDH – ''Geobacillus stearothermophilus''<BR />
 
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**[[1ldm]], [[6ldh]], [[8ldh]] – sdM4-LDH – spiny dogfish<BR />
 
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**[[4m1q]] - BseL-LDH – ''Bacillus selenitireducens''<br />
 
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**[[3pqe]] – BsL-LDH (mutant) – ''Bacillus subtilis''<br />
 
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**[[4lmr]], [[4ln1]] - LDH – ''Bacillus cereus''<br />
 
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**[[3vpg]] – TcLDH – ''Thermus caldophilus''<br />
 
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**[[3wsv]] – EmLDH – ''Enteroccocus mundtii''<br />
 
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**[[4uum]] – TvL-LDH – ''Trichomonas vaginalis''<br />
 
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**[[4uul]] – TvL-LDH (mutant)<br />
 
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**[[5hs4]] - PvL-LDH – ''Plasmodium vivax''<br />
 
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**[[6or9]] – LDH – ''Trichoplusia''<br />
 
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**[[6k12]] – BmLDH – ''Babesia microti''<br />
 
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**[[6j9d]] – BmLDH (mutant)<br />
 
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*L-LDH from yeast (cytochrome b2)
 
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**[[1kbj]] - LDH FMN-binding domain <br />
 
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**[[1sze]], [[1lco]], [[2oz0]] - LDH FMN-binding domain (mutant) <br />
 
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**[[1kbi]] - LDH FMN-binding domain + pyruvate<br />
 
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**[[1szf]], [[1ldc]] - LDH FMN-binding domain (mutant) + pyruvate<br />
 
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**[[1szg]] - LDH FMN-binding domain + sulfo-FMN<br />
 
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**[[3ks0]] - LDH residues 86-180 + flavocytochrome b2 heme domain + FAB B2B4
 
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*''L-LDH binary complex''
 
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**[[4ajp]], [[4m49]], [[4qsm]], [[4qt0]], [[5w8h]], [[5w8i]], [[5w8j]] – hLDH A chain + inhibitor <br />
 
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**[[4l4s]] – hLDH α chain + NAD <br />
 
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**[[5zje]] - hL-LDH A chain + malonate <br />
 
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**[[5zjf]] - hL-LDH A chain + machilin<br />
 
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**[[4i8x]], [[4i9h]], [[4i9n]], [[4i9u]] – rLDH A chain + pyridine derivative - rabbit<br />
 
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**[[4aj1]], [[4aj2]], [[4aj4]], [[4aje]], [[4ajh]], [[4aji]], [[4ajj]], [[4ajk]], [[4ajl]], [[4ajn]], [[4ajo]], [[4al4]], [[5kkc]] – raL-LDH A chain + inhibitor – rat<br />
 
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**[[5es3]] – raL-LDH + oxamate<br />
 
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**[[5nqb]] – raL-LDH A chain (mutant) + malonate<br />
 
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**[[4b7u]] – PfL-LDH + bicine<BR />
 
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**[[1cet]] - PfL-LDH + chloroquine<BR />
 
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**[[1t2c]] - PfL-LDH + NAD<BR />
 
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**[[3zh2]] - PfL-LDH + DNA aptamer<br />
 
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**[[1ez4]] - L-LDH + NAD – ''Lactobacillus pentosus''<BR />
 
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**[[1lld]], [[2ldb]] - GsL-LDH + NAD<BR />
 
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**[[2a92]] – PvL-LDH + NAD <BR />
 
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**[[2a94]], [[2aa3]] - PvL-LDH + NAD-analog<br />
 
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**[[5hru]], [[5hto]] - PvL-LDH + DNA<br />
 
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**[[1u4o]], [[1u4s]], [[1u5a]], [[1xiv]] – PfL-LDH + inhibitor<BR />
 
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**[[2xxb]] – TtL-LDH (mutant) + AMP<br />
 
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**[[3pqf]] – BsL-LDH (mutant) + NAD<br />
 
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**[[6j9t]] - LcLDH + fructose-bisphosphate<br />
 
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**[[6j9u]] – LcLDH (mutant) + pyruvate<br />
 
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**[[4uun]] – TvL-LDH + NAD<br />
 
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**[[6h9s]] – LDH + NAD – ''Petrotoga mobilis''<br />
 
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*''L-LDH ternary complex with inhibitor''
 
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**[[1t2f]] - hL-LDH B chain + azole derivative + NAD <BR />
 
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**[[1i0z]] - hL-LDH H chain + oxamate + NAD<BR />
 
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**[[1i10]] - hL-LDH M chain + oxamate + NAD<BR />
 
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**[[4qo7]], [[4qo8]], [[4r68]], [[4r69]], [[4rls]], [[4zvv]], [[5ixs]], [[5ixy]], [[5w8k]], [[5w8l]], [[6bad]], [[6bag]], [[6bax]], [[6baz]], [[6bb0]], [[6bb1]], [[6bb2]], [[6bb3]] - hL-LDH A chain + inhibitor + NAD<br />
 
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**[[5zjd]] - hL-LDH A chain + malonate + NAD<br />
 
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**[[9ldb]], [[9ldt]], [[6cep]], [[5yta]] - pL-LDH + oxamate + NAD – pig<br />
 
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**[[3h3f]] – rL-LDH A chain + oxamate + NAD <BR />
 
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**[[5nqq]] - rL-LDH A chain + oxalacetate + NAD<br />
 
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**[[1u5c]] - PfL-LDH + inhibitor + NAD<BR />
 
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**[[1t24]], [[1t25]], [[1t26]] - PfL-LDH + azole derivative + NAD<BR />
 
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**[[1t2e]] - PfL-LDH (mutant) + oxamate + NAD<BR />
 
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**[[1ldg]], [[4plz]] - PfL-LDH + oxamate + NAD<BR />
 
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**[[1t2d]] - PfL-LDH + oxalate + NAD<BR />
 
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**[[2xxj]] – TtL-LDH (mutant) + oxamate + NAD<BR />
 
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**[[2v7p]] - TtL-LDH + oxamate + NAD<BR />
 
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**[[3om9]], [[3czm]] – TgL-LDH + OXQ + NAD<BR />
 
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**[[1sow]], [[1pzh]] - TgL-LDH + oxalate + NAD<BR />
 
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**[[1pzf]] - TgL-LDH + oxalate + NAD-analog<br />
 
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**[[1pzg]] - TgL-LDH + sulfate + NAD-analog<br />
 
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**[[4nd1]] - CpLDH + oxamate + NAD<BR />
 
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**[[3wsw]] – EmL-LDH + NAD + fructose diphosphate<br />
 
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**[[1oc4]] – L-LDH + oxamate + NAD – ''Plasmodium berghei''<BR />
 
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**[[1a5z]] - L-LDH + oxamate + NAD – ''Thermotoga maritim''a<BR />
 
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**[[1lth]] - L-LDH + oxamate + NAD – ''Bifidobacterium longum''<BR />
 
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**[[1ldn]] - GsL-LDH + oxamate + NAD<BR />
 
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**[[4plc]], [[4plf]] – ApLDH + NAD + pyruvate - ''Apicomplexa''<br />
 
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**[[4plg]] – ApLDH + NAD + oxamate <br />
 
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**[[5a1t]] – TvL-LDH + NAD + oxamate<br />
 
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**[[6k13]] – BmLDH + NAD + oxamate <br />
 
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**[[6ct6]] – LDH + NAD + oxamate – ''Eimeria maxima''<br />
 
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*''L-LDH ternary complex with reactants''
 
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**[[5ldh]] - pLDH + citrate + NAD-analog<br />
 
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**[[3h3j]] – SaL-LDH (mutant) + pyruvate + NAD<BR />
 
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**[[3d4p]] - SaL-LDH + pyruvate + NAD<BR />
 
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**[[2fn7]] - CpLDH + lactate + NAD<BR />
 
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**[[4nd2]] - CpLDH + pyruvate + NAD-analog<br />
 
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**[[4nd4]] - CpLDH + pyruvate + NAD<BR />
 
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**[[3ldh]] - sdLDH + pyruvate + NAD<BR />
 
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**[[3pqd]] - BsLDH + fructose-bisphosphate + NAD
 
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*L-LDH quaternary complex
 
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**[[4jnk]] - hL-LDH A chain + inhibitor + lactate + NAD<br />
 
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**[[4okn]] - hL-LDH A chain + katamycin+ oxalate + NAD<br />
 
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**[[3vph]] - TcL-LDH + oxamate + NAD + fructose diphosphate<br />
 
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*D-LDH
 
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**[[3kb6]] – D-LDH + lactate + NAD – ''Aquifex aeolicus''<BR />
 
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**[[1j49]] – LdD-LDH + sulfate + NAD – ''Lactobacillus delbrueckii''<BR />
 
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**[[1j4a]] - LdD-LDH + sulfate<BR />
 
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**[[1f0x]] – EcD-LDH + FAD – ''Escherichia coli''<BR />
 
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**[[2dld]] - D-LDH + oxamate + NAD – ''Lactobacillus helveticus''<br />
 
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**[[3wwy]], [[6abi]] – FnD-LDH – ''Fusobacterium nucleatum''<br />
 
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**[[5z21]] – FnD-LDH + NAD + oxamate<br />
 
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**[[3wwz]] – PaD-LDH – ''Peudomonas aeruginosa''<br />
 
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**[[5z20]] – FnD-LDH + NAD + oxamate<br />
 
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**[[4xkj]] – D-LDH + NAD – ''Sporolactobacillus inulinus''<br />
 
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**[[4cuj]] – SeD-LDH – ''Salmonella enterica''<br />
 
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**[[4cuk]] – SeD-LDH + NAD <br />
 
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*L-LDH II
 
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**[[1x0a]], [[1vbi]] – TtL-LDH II
 
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*L-Lactate/malate dehydrogenase
 
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**[[1hye]], [[1hyg]] – L-LDH/MDH – ''Methanocaldococcus jannaschi''<br />
 
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**[[2g8y]] - EcL-LDH/MDH
 
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}}
 
==Additional Information==
==Additional Information==
For additional information, see [[Carbohydrate Metabolism]]<br />
For additional information, see [[Carbohydrate Metabolism]]<br />
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*1- http://www.jbc.org/content/243/17/4526.full.pdf+html
*1- http://www.jbc.org/content/243/17/4526.full.pdf+html
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[[Category:Topic PagePa
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[[Category:Topic Page]]

Revision as of 10:36, 17 October 2019

Lactate dehydrogenase dimer complex with cofactor NAD and pyruvate (PDB code 4nd4)

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Additional Information

For additional information, see Carbohydrate Metabolism

Reference

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