This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Virus coat protein
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
'''Virus coat proteins''' (VCP) or capsid proteins coat the virus<ref>PMID:19825049</ref>. The various VCPs are designated as Vp1, Vp2, etc. The VCP P domain (protruding domain) in noroviruses binds histo blood group antigen receptors. The outer capsid protein '''VP4''' is a virus spike-forming protein which mediates the virial attachment to the host epithelial cell receptors. VP4 is an outer capsid protein of non-enveloped viruses. VP4 attaches to sialic acid or to integrin heterodimers<ref>PMID:2538649</ref>. VP4 domains include: '''VP5*''' which forms the foot of the spike and acts in the permeabilization of the cell membrane and '''VP8*''' which forms the head of the spike and binds to sialic acid. | '''Virus coat proteins''' (VCP) or capsid proteins coat the virus<ref>PMID:19825049</ref>. The various VCPs are designated as Vp1, Vp2, etc. The VCP P domain (protruding domain) in noroviruses binds histo blood group antigen receptors. The outer capsid protein '''VP4''' is a virus spike-forming protein which mediates the virial attachment to the host epithelial cell receptors. VP4 is an outer capsid protein of non-enveloped viruses. VP4 attaches to sialic acid or to integrin heterodimers<ref>PMID:2538649</ref>. VP4 domains include: '''VP5*''' which forms the foot of the spike and acts in the permeabilization of the cell membrane and '''VP8*''' which forms the head of the spike and binds to sialic acid. | ||
| - | The biological assembly of HIV-I coat protein is <scene name='51/516486/Cv/ | + | The biological assembly of HIV-I coat protein is <scene name='51/516486/Cv/4'>homohexamer</scene> (PDB entry [[3gv2]]). |
For details on Zika virus capsid protein see [[Hugo Heringer de Almeida/5YGH]]. | For details on Zika virus capsid protein see [[Hugo Heringer de Almeida/5YGH]]. | ||
Revision as of 12:48, 17 October 2019
| |||||||||||
3D structures of virus coat proteins
Updated on 17-October-2019
