Vpu protein

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== Function ==
== Function ==
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'''Vpu protein''' (Vpu) or '''viral protein U''' is a viroporin encoded by HIV-1<ref>PMID:26247957</ref>. Vpu is a multifunctional enhancer of viral particle release<ref>PMID:12941395</ref>. <scene name='75/750240/Cv/1'>HIV-1 Vpu protein complex with adapter-related protein complex 1 subunits γ-1, σ-1a, μ-1, β-1</scene> (PDB code [[4p6z]]).
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'''Vpu protein''' (Vpu) or '''viral protein U''' is a viroporin encoded by HIV-1<ref>PMID:26247957</ref>. Vpu is a multifunctional enhancer of viral particle release<ref>PMID:12941395</ref>. <scene name='75/750240/Cv/3'>HIV-1 Vpu protein complex with adapter-related protein complex 1 subunits γ-1, σ-1a, μ-1, β-1</scene> (PDB code [[4p6z]]).
For details see [[HIV and accessory proteins]].
For details see [[HIV and accessory proteins]].

Revision as of 13:09, 17 October 2019

HIV-1 Vpu protein (dark olive) complex with adapter-related protein complex 1 subunits γ-1 (gold), σ-1a (khaki), μ-1 (olive green), β-1 (green) (PDB code 4p6z)

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3D Structures of Vpu protein

Updated on 17-October-2019

2n28 – Vpu - HIV-1 - NMR
1pi7, 1pi8, 1pje, 2gof, 2goh – Vpu trans-membrane domain - NMR
1vpu, 2n29, 2k7y – Vpu cytoplasmic domain - NMR
4p6z – Vpu cytoplasmic domain + BST2 + AP-1 core

References

  1. ↑ Gonzalez ME. Vpu Protein: The Viroporin Encoded by HIV-1. Viruses. 2015 Aug 4;7(8):4352-68. doi: 10.3390/v7082824. PMID:26247957 doi:http://dx.doi.org/10.3390/v7082824
  2. ↑ Bour S, Strebel K. The HIV-1 Vpu protein: a multifunctional enhancer of viral particle release. Microbes Infect. 2003 Sep;5(11):1029-39. PMID:12941395

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky

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