6ndu
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of human PACRG-MEIG1 complex== | |
| - | + | <StructureSection load='6ndu' size='340' side='right'caption='[[6ndu]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6ndu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NDU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NDU FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6nep|6nep]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ndu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ndu OCA], [http://pdbe.org/6ndu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ndu RCSB], [http://www.ebi.ac.uk/pdbsum/6ndu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ndu ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PACRG_HUMAN PACRG_HUMAN]] Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.<ref>PMID:14532270</ref> [[http://www.uniprot.org/uniprot/MEIG1_HUMAN MEIG1_HUMAN]] Essential for spermiogenesis. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Croteau, N]] | ||
| + | [[Category: Khan, N]] | ||
[[Category: Pelletier, D]] | [[Category: Pelletier, D]] | ||
| + | [[Category: Trempe, J F]] | ||
[[Category: Veyron, S]] | [[Category: Veyron, S]] | ||
| - | [[Category: | + | [[Category: Axoneme]] |
| - | [[Category: | + | [[Category: Flagella]] |
| - | [[Category: | + | [[Category: Microtubule]] |
| + | [[Category: Primary cilia]] | ||
| + | [[Category: Structural protein]] | ||
Revision as of 06:54, 23 October 2019
Structure of human PACRG-MEIG1 complex
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