6u09
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking== | |
| - | + | <StructureSection load='6u09' size='340' side='right'caption='[[6u09]], [[Resolution|resolution]] 1.79Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6u09]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U09 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U09 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EI9:3-{(1-oxo-1,2-dihydroisoquinolin-7-yl)[(pyridin-4-yl)methyl]sulfamoyl}benzene-1-sulfonyl+fluoride'>EI9</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6u06|6u06]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6u09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u09 OCA], [http://pdbe.org/6u09 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u09 RCSB], [http://www.ebi.ac.uk/pdbsum/6u09 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u09 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IF4E_MOUSE IF4E_MOUSE]] Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity). Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:18805096</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Shoichet, B K]] | ||
[[Category: Taunton, J]] | [[Category: Taunton, J]] | ||
| - | [[Category: Wan, X | + | [[Category: Wan, X B]] |
| - | [[Category: | + | [[Category: Anti-neoplastic]] |
| + | [[Category: Cap-binding site]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Translation initiation blocking]] | ||
| + | [[Category: Translation-inhibitor complex]] | ||
Revision as of 07:04, 23 October 2019
Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking
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