5l9z

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==Crystal structure of human heparanase nucleophile mutant (E343Q), in complex with unreacted glucuronic acid configured aziridine probe JJB355==
==Crystal structure of human heparanase nucleophile mutant (E343Q), in complex with unreacted glucuronic acid configured aziridine probe JJB355==
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<StructureSection load='5l9z' size='340' side='right' caption='[[5l9z]], [[Resolution|resolution]] 1.57&Aring;' scene=''>
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<StructureSection load='5l9z' size='340' side='right'caption='[[5l9z]], [[Resolution|resolution]] 1.57&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5l9z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L9Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L9Z FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5l9z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L9Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L9Z FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GUX:(1~{R},2~{S},3~{R},4~{S},5~{S},6~{R})-7-[8-[(azanylidene-{4}-azanylidene)amino]octyl]-3,4,5-tris(oxidanyl)-7-azabicyclo[4.1.0]heptane-2-carboxylic+acid'>GUX</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GUX:(1~{R},2~{S},3~{R},4~{S},5~{S},6~{R})-7-[8-[(azanylidene-{4}-azanylidene)amino]octyl]-3,4,5-tris(oxidanyl)-7-azabicyclo[4.1.0]heptane-2-carboxylic+acid'>GUX</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HPSE, HEP, HPA, HPA1, HPR1, HPSE1, HSE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Heparanase Heparanase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.166 3.2.1.166] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Heparanase Heparanase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.166 3.2.1.166] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l9z OCA], [http://pdbe.org/5l9z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l9z RCSB], [http://www.ebi.ac.uk/pdbsum/5l9z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l9z ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l9z OCA], [http://pdbe.org/5l9z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l9z RCSB], [http://www.ebi.ac.uk/pdbsum/5l9z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l9z ProSAT]</span></td></tr>
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</StructureSection>
</StructureSection>
[[Category: Heparanase]]
[[Category: Heparanase]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Davies, G J]]
[[Category: Davies, G J]]
[[Category: Jin, Y]]
[[Category: Jin, Y]]

Revision as of 07:39, 23 October 2019

Crystal structure of human heparanase nucleophile mutant (E343Q), in complex with unreacted glucuronic acid configured aziridine probe JJB355

PDB ID 5l9z

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