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1fx3

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Revision as of 08:46, 23 October 2019

CRYSTAL STRUCTURE OF H. INFLUENZAE SECB

Structural highlights

1fx3 is a 4 chain structure with sequence from "bacterium_influenzae"_lehmann_and_neumann_1896 "bacterium influenzae" lehmann and neumann 1896. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[SECB_HAEIN] One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

SecB is a bacterial molecular chaperone involved in mediating translocation of newly synthesized polypeptides across the cytoplasmic membrane of bacteria. The crystal structure of SecB from Haemophilus influenzae shows that the molecule is a tetramer organized as a dimer of dimers. Two long channels run along the side of the molecule. These are bounded by flexible loops and lined with conserved hydrophobic amino acids, which define a suitable environment for binding non-native polypeptides. The structure also reveals an acidic region on the top surface of the molecule, several residues of which have been implicated in binding to SecA, its downstream target.

Crystal structure of the bacterial protein export chaperone secB.,Xu Z, Knafels JD, Yoshino K Nat Struct Biol. 2000 Dec;7(12):1172-7. PMID:11101901^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Xu Z, Knafels JD, Yoshino K. Crystal structure of the bacterial protein export chaperone secB. Nat Struct Biol. 2000 Dec;7(12):1172-7. PMID:11101901 doi:10.1038/82040

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1fx3"

@@ Line 1: / Line 1: @@
 ==CRYSTAL STRUCTURE OF H. INFLUENZAE SECB==
-<StructureSection load='1fx3' size='340' side='right' caption='[[1fx3]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+<StructureSection load='1fx3' size='340' side='right'caption='[[1fx3]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 == Structural highlights ==
 <table><tr><td colspan='2'>[[1fx3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_influenzae"_lehmann_and_neumann_1896 "bacterium influenzae" lehmann and neumann 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FX3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FX3 FirstGlance]. <br>
@@ Line 32: / Line 32: @@
 </StructureSection>
 [[Category: Bacterium influenzae lehmann and neumann 1896]]
+[[Category: Large Structures]]
 [[Category: Knafels, J D]]
 [[Category: Xu, Z]]

1fx3

From Proteopedia

Revision as of 08:46, 23 October 2019

CRYSTAL STRUCTURE OF H. INFLUENZAE SECB

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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