Major histocompatibility complex

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<scene name='45/457390/Cv/5'>Human MHC class I antigen with β 2-microglobulin and peptide from Hepatitis virus</scene>.
<scene name='45/457390/Cv/5'>Human MHC class I antigen with β 2-microglobulin and peptide from Hepatitis virus</scene>.
The <scene name='45/457390/Cv/6'>peptide derived from Hepatitis virus binds MHC in a peptide-recognition groove and makes various interactions with side chains and with water molecules</scene><ref>PMID:21538979</ref>. Water molecules shown as red spheres.
The <scene name='45/457390/Cv/6'>peptide derived from Hepatitis virus binds MHC in a peptide-recognition groove and makes various interactions with side chains and with water molecules</scene><ref>PMID:21538979</ref>. Water molecules shown as red spheres.
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==3D structures of MHC==
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[[MHC 3D structures of MHC]]
</StructureSection>
</StructureSection>
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*MHC I binary complex
*MHC I binary complex
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**[[1zs8]] - mMHC I + β-2-microglobulin – mouse<br />
 
**[[2hla]], [[3hla]], [[1hla]] - hMHC I + β-2-microglobulin – human<br />
**[[2hla]], [[3hla]], [[1hla]] - hMHC I + β-2-microglobulin – human<br />
 +
**[[1zs8]] - mMHC I + β-2-microglobulin – mouse<br />
**[[3p73]], [[3p77]] - cMHC I + β-2-microglobulin – chicken
**[[3p73]], [[3p77]] - cMHC I + β-2-microglobulin – chicken
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**[[3e2h]], [[3e3q]], [[2e7l]] - mMHC I α (mutant) + T cell receptor + peptide<br />
**[[3e2h]], [[3e3q]], [[2e7l]] - mMHC I α (mutant) + T cell receptor + peptide<br />
**[[1nez]] - mMHC I + β-2-microglobulin + CD8 α chain<br />
**[[1nez]] - mMHC I + β-2-microglobulin + CD8 α chain<br />
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**[[3rwc]], [[3rwd]], [[3rwe]], [[3rwf]], [[3rwg]], [[3rwh]], [[3rwi]], [[3rwj]], [[4zfz]] - MHC I + β-2-microglobulin + peptide – Rhesus macaque<br />
+
**[[3rwc]], [[3rwd]], [[3rwe]], [[3rwf]], [[3rwg]], [[3rwh]], [[3rwi]], [[3rwj]], [[4zfz]], [[6iwg]], [[6hwj]] - MHC I + β-2-microglobulin + peptide – Rhesus macaque<br />
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**[[3qq3]], [[3qq4]] - MHC I + β-2-microglobulin + peptide - pig
+
**[[3qq3]], [[3qq4]] - MHC I + β-2-microglobulin + peptide - pig<br />
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**[[4d0b]], [[3bew]], [[2yez]], [[5ad0]], [[4d0c]], [[3bev]], [[4cvx]], [[4cvx]], [[4cvz]], [[4d0d]], [[4cw1]] – cMHC I α + β-2-microglobulin + peptide<br />
*MHC I quaternary complex
*MHC I quaternary complex

Revision as of 07:32, 28 October 2019

Human MHC class I antigen (cyan) with β 2-microglobulin (green) and peptide from Hepatitis virus (deeppink) 3ox8

Drag the structure with the mouse to rotate

3D structures of MHC

Updated on 28-October-2019

References

  1. ↑ Raghavan M, Del Cid N, Rizvi SM, Peters LR. MHC class I assembly: out and about. Trends Immunol. 2008 Sep;29(9):436-43. doi: 10.1016/j.it.2008.06.004. PMID:18675588 doi:http://dx.doi.org/10.1016/j.it.2008.06.004
  2. ↑ Holling TM, Schooten E, van Den Elsen PJ. Function and regulation of MHC class II molecules in T-lymphocytes: of mice and men. Hum Immunol. 2004 Apr;65(4):282-90. PMID:15120183 doi:http://dx.doi.org/10.1016/j.humimm.2004.01.005
  3. ↑ Liu J, Chen KY, Ren EC. Structural insights into the binding of hepatitis B virus core peptide to HLA-A2 alleles: Towards designing better vaccines. Eur J Immunol. 2011 Jul;41(7):2097-106. doi: 10.1002/eji.201041370. PMID:21538979 doi:10.1002/eji.201041370
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