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| - | | + | #REDIRECT [[6uap]] This PDB entry is obsolete and replaced by 6uap |
| - | ==Crystal structure of tryptophan synthase from M. tuberculosis - open form with BRD6309 bound==
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| - | <StructureSection load='6du1' size='340' side='right' caption='[[6du1]], [[Resolution|resolution]] 2.74Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[6du1]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DU1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DU1 FirstGlance]. <br>
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| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=H9V:(2R,3S,4R)-3-(4-chloro-2,6-difluoro[1,1-biphenyl]-4-yl)-4-(fluoromethyl)azetidine-2-carbonitrile'>H9V</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene>, <scene name='pdbligand=MLT:D-MALATE'>MLT</scene></td></tr>
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| - | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
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| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_synthase Tryptophan synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.20 4.2.1.20] </span></td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6du1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6du1 OCA], [http://pdbe.org/6du1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6du1 RCSB], [http://www.ebi.ac.uk/pdbsum/6du1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6du1 ProSAT]</span></td></tr>
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| - | </table>
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/TRPA_MYCTU TRPA_MYCTU]] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. [[http://www.uniprot.org/uniprot/TRPB_MYCTU TRPB_MYCTU]] The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine (By similarity).
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Tryptophan synthase]]
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| - | [[Category: Structural genomic]]
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| - | [[Category: Chang, C]]
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| - | [[Category: Jedrzejczak, R]]
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| - | [[Category: Joachimiak, A]]
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| - | [[Category: Maltseva, N I]]
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| - | [[Category: McCarren, P]]
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| - | [[Category: Michalska, K]]
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| - | [[Category: Nag, P P]]
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| - | [[Category: Satchell, K]]
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| - | [[Category: Allostery]]
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| - | [[Category: Amino acid biosynthesis]]
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| - | [[Category: Csgid]]
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| - | [[Category: Heterotetramer]]
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| - | [[Category: Lyase-lyase inhibitor complex]]
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| - | [[Category: Plp]]
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| - | [[Category: Substrate channeling]]
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