|
|
| Line 1: |
Line 1: |
| - | | + | #REDIRECT [[6ub9]] This PDB entry is obsolete and replaced by 6ub9 |
| - | ==Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and BRD6309-bound form==
| + | |
| - | <StructureSection load='6dua' size='340' side='right' caption='[[6dua]], [[Resolution|resolution]] 2.78Å' scene=''>
| + | |
| - | == Structural highlights ==
| + | |
| - | <table><tr><td colspan='2'>[[6dua]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DUA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DUA FirstGlance]. <br>
| + | |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=H9V:(2R,3S,4R)-3-(4-chloro-2,6-difluoro[1,1-biphenyl]-4-yl)-4-(fluoromethyl)azetidine-2-carbonitrile'>H9V</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene>, <scene name='pdbligand=P1T:2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC+ACID'>P1T</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
| + | |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_synthase Tryptophan synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.20 4.2.1.20] </span></td></tr>
| + | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dua OCA], [http://pdbe.org/6dua PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dua RCSB], [http://www.ebi.ac.uk/pdbsum/6dua PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dua ProSAT]</span></td></tr>
| + | |
| - | </table>
| + | |
| - | == Function ==
| + | |
| - | [[http://www.uniprot.org/uniprot/TRPA_MYCTU TRPA_MYCTU]] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. [[http://www.uniprot.org/uniprot/TRPB_MYCTU TRPB_MYCTU]] The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine (By similarity).
| + | |
| - | __TOC__
| + | |
| - | </StructureSection>
| + | |
| - | [[Category: Tryptophan synthase]]
| + | |
| - | [[Category: Structural genomic]]
| + | |
| - | [[Category: Chang, C]]
| + | |
| - | [[Category: Jedrzejczak, R]]
| + | |
| - | [[Category: Joachimiak, A]]
| + | |
| - | [[Category: Maltseva, N I]]
| + | |
| - | [[Category: McCarren, P]]
| + | |
| - | [[Category: Michalska, K]]
| + | |
| - | [[Category: Nag, P P]]
| + | |
| - | [[Category: Satchell, K]]
| + | |
| - | [[Category: Allostery]]
| + | |
| - | [[Category: Amino acid biosynthesis]]
| + | |
| - | [[Category: Csgid]]
| + | |
| - | [[Category: Heterotetramer]]
| + | |
| - | [[Category: Lyase-lyase inhibitor complex]]
| + | |
| - | [[Category: Plp]]
| + | |
| - | [[Category: Substrate channeling]]
| + | |
