6uap

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m (Protected "6uap" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6uap is ON HOLD
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==Crystal structure of tryptophan synthase from M. tuberculosis - open form with BRD6309 bound==
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<StructureSection load='6uap' size='340' side='right'caption='[[6uap]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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Authors: Chang, C., Michalska, K., Maltseva, N.I., Jedrzejczak, R., McCarren, P., Nag, P.P., Joachimiak, A., Satchell, K., Center for Structural Genomics of Infectious Diseases (CSGID)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6uap]] is a 8 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=6du1 6du1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UAP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UAP FirstGlance]. <br>
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Description: Crystal structure of tryptophan synthase from M. tuberculosis -open form with BRD6309 bound
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=H9V:(2R,3S,4R)-3-(4-chloro-2,6-difluoro[1,1-biphenyl]-4-yl)-4-(fluoromethyl)azetidine-2-carbonitrile'>H9V</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene>, <scene name='pdbligand=MLT:D-MALATE'>MLT</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_synthase Tryptophan synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.20 4.2.1.20] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6uap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uap OCA], [http://pdbe.org/6uap PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uap RCSB], [http://www.ebi.ac.uk/pdbsum/6uap PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uap ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/TRPA_MYCTU TRPA_MYCTU]] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. [[http://www.uniprot.org/uniprot/TRPB_MYCTU TRPB_MYCTU]] The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine (By similarity).
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Tryptophan synthase]]
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[[Category: Structural genomic]]
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[[Category: Chang, C]]
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[[Category: Jedrzejczak, R]]
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[[Category: Joachimiak, A]]
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[[Category: Maltseva, N I]]
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[[Category: McCarren, P]]
[[Category: Michalska, K]]
[[Category: Michalska, K]]
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[[Category: Mccarren, P]]
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[[Category: Nag, P P]]
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[[Category: Joachimiak, A]]
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[[Category: Maltseva, N.I]]
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[[Category: Satchell, K]]
[[Category: Satchell, K]]
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[[Category: Jedrzejczak, R]]
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[[Category: Allostery]]
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[[Category: Center For Structural Genomics Of Infectious Diseases (Csgid)]]
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[[Category: Amino acid biosynthesis]]
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[[Category: Chang, C]]
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[[Category: Csgid]]
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[[Category: Nag, P.P]]
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[[Category: Heterotetramer]]
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[[Category: Lyase-lyase inhibitor complex]]
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[[Category: Plp]]
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[[Category: Substrate channeling]]

Revision as of 08:57, 30 October 2019

Crystal structure of tryptophan synthase from M. tuberculosis - open form with BRD6309 bound

PDB ID 6uap

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