6hxr
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Human PARP16 (ARTD15) IN COMPLEX WITH EB-47== | |
| - | + | <StructureSection load='6hxr' size='340' side='right'caption='[[6hxr]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6hxr]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HXR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HXR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UHB:2-[4-[(2S,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-BIS(OXIDANYL)OXOLAN-2-YL]CARBONYLPIPERAZIN-1-YL]-N-(1-OXIDANYLIDENE-2,3-DIHYDROISOINDOL-4-YL)ETHANAMIDE'>UHB</scene></td></tr> | |
| - | [[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hxr OCA], [http://pdbe.org/6hxr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hxr RCSB], [http://www.ebi.ac.uk/pdbsum/6hxr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hxr ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PAR16_HUMAN PAR16_HUMAN]] Mono-ADP-ribosyltransferase targeting the karyopherin KPNB1. Plays a role in unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors.<ref>PMID:23103912</ref> <ref>PMID:22701565</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Karlberg, T]] | [[Category: Karlberg, T]] | ||
| - | [[Category: | + | [[Category: Pinto, A F]] |
[[Category: Schuler, H]] | [[Category: Schuler, H]] | ||
| + | [[Category: Thorsell, A G]] | ||
| + | [[Category: Adp-ribose]] | ||
| + | [[Category: Adp-ribosylation]] | ||
| + | [[Category: Artd15]] | ||
| + | [[Category: Eb-47]] | ||
| + | [[Category: Inhibitor complex]] | ||
| + | [[Category: Parp16]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 08:58, 30 October 2019
Human PARP16 (ARTD15) IN COMPLEX WITH EB-47
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