6hxs

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m (Protected "6hxs" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6hxs is ON HOLD
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==Human PARP16 (ARTD15) IN COMPLEX WITH CARBA-NAD==
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<StructureSection load='6hxs' size='340' side='right'caption='[[6hxs]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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Authors: Karlberg, T., Pinto, A.F., Thorsell, A.G., Schuler, H.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6hxs]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HXS FirstGlance]. <br>
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Description: Human PARP16 (ARTD15) IN COMPLEX WITH CARBA-NAD
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=CNA:CARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>CNA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6hxr|6hxr]]</td></tr>
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[[Category: Pinto, A.F]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hxs OCA], [http://pdbe.org/6hxs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hxs RCSB], [http://www.ebi.ac.uk/pdbsum/6hxs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hxs ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/PAR16_HUMAN PAR16_HUMAN]] Mono-ADP-ribosyltransferase targeting the karyopherin KPNB1. Plays a role in unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors.<ref>PMID:23103912</ref> <ref>PMID:22701565</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Karlberg, T]]
[[Category: Karlberg, T]]
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[[Category: Thorsell, A.G]]
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[[Category: Pinto, A F]]
[[Category: Schuler, H]]
[[Category: Schuler, H]]
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[[Category: Thorsell, A G]]
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[[Category: Adp-ribose]]
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[[Category: Adp-ribosylation]]
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[[Category: Artd15]]
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[[Category: Carba-nad]]
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[[Category: Parp16]]
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[[Category: Substrate]]
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[[Category: Transferase]]

Revision as of 08:58, 30 October 2019

Human PARP16 (ARTD15) IN COMPLEX WITH CARBA-NAD

PDB ID 6hxs

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