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6in3
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of DOT1L in complex with 18-Crown-6== | |
| - | + | <StructureSection load='6in3' size='340' side='right'caption='[[6in3]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6in3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IN3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IN3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=O4B:1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE'>O4B</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6in3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6in3 OCA], [http://pdbe.org/6in3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6in3 RCSB], [http://www.ebi.ac.uk/pdbsum/6in3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6in3 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN]] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Histone-lysine N-methyltransferase]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Kitakami, R]] | ||
| + | [[Category: Kosaka, Y]] | ||
| + | [[Category: Matsumoto, K]] | ||
| + | [[Category: Mizuguchi, M]] | ||
| + | [[Category: Nabeshima, Y]] | ||
| + | [[Category: Yokoyama, T]] | ||
| + | [[Category: Histone h3k79 methyltransferase]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 08:59, 30 October 2019
Crystal structure of DOT1L in complex with 18-Crown-6
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