6kmb

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'''Unreleased structure'''
 
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The entry 6kmb is ON HOLD until Paper Publication
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==Crystal structure of Sth1 bromodomain==
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<StructureSection load='6kmb' size='340' side='right'caption='[[6kmb]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6kmb]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KMB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KMB FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_helicase DNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.12 3.6.4.12] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6kmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kmb OCA], [http://pdbe.org/6kmb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kmb RCSB], [http://www.ebi.ac.uk/pdbsum/6kmb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kmb ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/STH1_YEAST STH1_YEAST]] Catalytic component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is the essential ATPase of the complex. It is a DNA translocase capable of nucleosome remodeling. Required for full expression of early meiotic genes. Essential for mitotic growth and repression of CHA1 expression. Also involved in G2 phase control.<ref>PMID:10025404</ref> <ref>PMID:10320476</ref> <ref>PMID:10329629</ref> <ref>PMID:12072455</ref> <ref>PMID:12183366</ref> <ref>PMID:12697820</ref> <ref>PMID:8980231</ref> <ref>PMID:9799253</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: DNA helicase]]
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[[Category: Large Structures]]
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[[Category: Chen, G]]
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[[Category: Chen, Y]]
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[[Category: Li, W]]
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[[Category: Wang, D]]
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[[Category: Yan, F]]
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[[Category: Bromodomain]]
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[[Category: Chromatin remodeling]]
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[[Category: Gene regulation]]
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[[Category: Histone acetylation]]
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[[Category: Rsc complex]]
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[[Category: Sth1]]

Revision as of 09:04, 30 October 2019

Crystal structure of Sth1 bromodomain

PDB ID 6kmb

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