2uva

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[[Image:2uva.gif|left|200px]]
[[Image:2uva.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2uva |SIZE=350|CAPTION= <scene name='initialview01'>2uva</scene>, resolution 3.1&Aring;
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The line below this paragraph, containing "STRUCTURE_2uva", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Fmn+Binding+Site+For+Chain+G'>AC1</scene>, <scene name='pdbsite=AC2:Fmn+Binding+Site+For+Chain+H'>AC2</scene>, <scene name='pdbsite=AC3:Fmn+Binding+Site+For+Chain+I'>AC3</scene>, <scene name='pdbsite=AC4:Fmn+Binding+Site+For+Chain+J'>AC4</scene>, <scene name='pdbsite=AC5:Fmn+Binding+Site+For+Chain+K'>AC5</scene> and <scene name='pdbsite=AC6:Fmn+Binding+Site+For+Chain+L'>AC6</scene>
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|LIGAND= <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2uva| PDB=2uva | SCENE= }}
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|RELATEDENTRY=[[2uv9|2UV9]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uva OCA], [http://www.ebi.ac.uk/pdbsum/2uva PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2uva RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF FATTY ACID SYNTHASE FROM THERMOMYCES LANUGINOSUS AT 3.1 ANGSTROM RESOLUTION. THIS FILE CONTAINS THE BETA SUBUNITS OF THE FATTY ACID SYNTHASE. THE ENTIRE CRYSTAL STRUCTURE CONSISTS OF ONE HETERODODECAMERIC FATTY ACID SYNTHASE AND IS DESCRIBED IN REMARK 400'''
'''CRYSTAL STRUCTURE OF FATTY ACID SYNTHASE FROM THERMOMYCES LANUGINOSUS AT 3.1 ANGSTROM RESOLUTION. THIS FILE CONTAINS THE BETA SUBUNITS OF THE FATTY ACID SYNTHASE. THE ENTIRE CRYSTAL STRUCTURE CONSISTS OF ONE HETERODODECAMERIC FATTY ACID SYNTHASE AND IS DESCRIBED IN REMARK 400'''
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[[Category: Leibundgut, M.]]
[[Category: Leibundgut, M.]]
[[Category: Mikolasek, B.]]
[[Category: Mikolasek, B.]]
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[[Category: acetyl transferase]]
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[[Category: Acetyl transferase]]
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[[Category: acyl carrier protein]]
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[[Category: Acyl carrier protein]]
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[[Category: dehydratase]]
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[[Category: Dehydratase]]
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[[Category: enoyl reductase]]
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[[Category: Enoyl reductase]]
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[[Category: fatty acid synthase]]
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[[Category: Fatty acid synthase]]
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[[Category: fatty acid synthesis]]
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[[Category: Fatty acid synthesis]]
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[[Category: fungal]]
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[[Category: Fungal]]
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[[Category: ketoacyl reductase]]
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[[Category: Ketoacyl reductase]]
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[[Category: ketoacyl synthase]]
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[[Category: Ketoacyl synthase]]
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[[Category: malonyl/palmitoyl transferase]]
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[[Category: Malonyl/palmitoyl transferase]]
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[[Category: multifunctional enzyme]]
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[[Category: Multifunctional enzyme]]
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[[Category: substrate shuttling]]
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[[Category: Substrate shuttling]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 13:50:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:04:57 2008''
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Revision as of 10:50, 30 April 2008

Image:2uva.gif

Template:STRUCTURE 2uva

CRYSTAL STRUCTURE OF FATTY ACID SYNTHASE FROM THERMOMYCES LANUGINOSUS AT 3.1 ANGSTROM RESOLUTION. THIS FILE CONTAINS THE BETA SUBUNITS OF THE FATTY ACID SYNTHASE. THE ENTIRE CRYSTAL STRUCTURE CONSISTS OF ONE HETERODODECAMERIC FATTY ACID SYNTHASE AND IS DESCRIBED IN REMARK 400


Overview

We report crystal structures of the 2.6-megadalton alpha6beta6 heterododecameric fatty acid synthase from Thermomyces lanuginosus at 3.1 angstrom resolution. The alpha and beta polypeptide chains form the six catalytic domains required for fatty acid synthesis and numerous expansion segments responsible for extensive intersubunit connections. Detailed views of all active sites provide insights into substrate specificities and catalytic mechanisms and reveal their unique characteristics, which are due to the integration into the multienzyme. The mode of acyl carrier protein attachment in the reaction chamber, together with the spatial distribution of active sites, suggests that iterative substrate shuttling is achieved by a relatively restricted circular motion of the carrier domain in the multifunctional enzyme.

About this Structure

2UVA is a Single protein structure of sequence from Thermomyces lanuginosus. Full crystallographic information is available from OCA.

Reference

Structure of fungal fatty acid synthase and implications for iterative substrate shuttling., Jenni S, Leibundgut M, Boehringer D, Frick C, Mikolasek B, Ban N, Science. 2007 Apr 13;316(5822):254-61. PMID:17431175 Page seeded by OCA on Wed Apr 30 13:50:59 2008

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