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Methanol dehydrogenase

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== Function ==
== Function ==
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'''Methanol dehydrogenase''' (MDH) is a quinoprotein which catalyzes the conversion of methanol and NAD+ or NADP+ to formaldeyde and NADH or NADPH and H+. MDH is a pyrroloquinoline quinone (PQQ)-dependent enzyme. MDH requires a divalent cation like Ca+2 for catalytic activity<ref>PMID:12686102</ref>.
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'''Methanol dehydrogenase''' or '''sulfoacetaldehyde reductase''' (MDH) is a quinoprotein which catalyzes the conversion of methanol and NAD+ or NADP+ to formaldeyde and NADH or NADPH and H+. MDH is a pyrroloquinoline quinone (PQQ)-dependent enzyme. MDH requires a divalent cation like Ca+2 for catalytic activity<ref>PMID:12686102</ref>.
== Structural highlights ==
== Structural highlights ==

Revision as of 09:15, 30 October 2019

Methanol dehydrogenase large subunit (cyan and deeppink) and small subunit (green and yellow) complex with cofactor PQQ and Ca+2 ion (green), 2ad6

Drag the structure with the mouse to rotate

3D structures of methanol dehydrogenase

Updated on 30-October-2019

4aah, 1g72, 2ad6, 2ad7, 2ad8 – MmMDH α+β + Ca + PQQ – Methylophilus methylotrophus
1h4i, 1w6s - MeMDH α+β + Ca + PQQ – Methylobacterium extorquens
1h4j - MeMDH α (mutant) +β + Ca + PQQ
1lrw - MDH α+β + Ca + PQQ – Paracoccus denitrificans
2d0v - MDH α+β + Ca + PQQ – Hyphomicrobium denitrificans
4mae - MfMDH + Ce + PQQ – Methylacidiphilum fumariolicum
6fkw - MfMDH + Eu + PQQ
4tqo - MDH + Ca + PQQ – Methylococcus capsulatus
5xm3 - MDH α+β + Mg + PQQ – Methylophaga aminisulfidivorans

References

  1. ↑ Anthony C, Williams P. The structure and mechanism of methanol dehydrogenase. Biochim Biophys Acta. 2003 Apr 11;1647(1-2):18-23. PMID:12686102
  2. ↑ Li J, Gan JH, Mathews FS, Xia ZX. The enzymatic reaction-induced configuration change of the prosthetic group PQQ of methanol dehydrogenase. Biochem Biophys Res Commun. 2011 Mar 25;406(4):621-6. Epub 2011 Feb 26. PMID:21356200 doi:10.1016/j.bbrc.2011.02.107

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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