6hcr

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<StructureSection load='6hcr' size='340' side='right'caption='[[6hcr]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<StructureSection load='6hcr' size='340' side='right'caption='[[6hcr]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6hcr]] is a 60 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HCR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HCR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6hcr]] is a 60 chain structure with sequence from [http://en.wikipedia.org/wiki/Ade03 Ade03]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HCR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HCR FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hcr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hcr OCA], [http://pdbe.org/6hcr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hcr RCSB], [http://www.ebi.ac.uk/pdbsum/6hcr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hcr ProSAT]</span></td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">L2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=45659 ADE03])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hcr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hcr OCA], [http://pdbe.org/6hcr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hcr RCSB], [http://www.ebi.ac.uk/pdbsum/6hcr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hcr ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Self-assembling virus-like particles represent highly attractive tools for developing next-generation vaccines and protein therapeutics. We created ADDomer, an adenovirus-derived multimeric protein-based self-assembling nanoparticle scaffold engineered to facilitate plug-and-play display of multiple immunogenic epitopes from pathogens. We used cryo-electron microscopy at near-atomic resolution and implemented novel, cost-effective, high-performance cloud computing to reveal architectural features in unprecedented detail. We analyzed ADDomer interaction with components of the immune system and developed a promising first-in-kind ADDomer-based vaccine candidate to combat emerging Chikungunya infectious disease, exemplifying the potential of our approach.
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Synthetic self-assembling ADDomer platform for highly efficient vaccination by genetically encoded multiepitope display.,Vragniau C, Bufton JC, Garzoni F, Stermann E, Rabi F, Terrat C, Guidetti M, Josserand V, Williams M, Woods CJ, Viedma G, Bates P, Verrier B, Chaperot L, Schaffitzel C, Berger I, Fender P Sci Adv. 2019 Sep 25;5(9):eaaw2853. doi: 10.1126/sciadv.aaw2853. eCollection 2019, Sep. PMID:31620562<ref>PMID:31620562</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6hcr" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ade03]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Berger, I]]
[[Category: Berger, I]]

Revision as of 09:30, 30 October 2019

Synthetic Self-assembling ADDomer Platform for Highly Efficient Vaccination by Genetically-encoded Multi-epitope Display

PDB ID 6hcr

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