1dpp

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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dpp OCA], [http://www.ebi.ac.uk/pdbsum/1dpp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dpp RCSB]</span>
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'''DIPEPTIDE BINDING PROTEIN COMPLEX WITH GLYCYL-L-LEUCINE'''
'''DIPEPTIDE BINDING PROTEIN COMPLEX WITH GLYCYL-L-LEUCINE'''
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[[Category: Dunten, P.]]
[[Category: Dunten, P.]]
[[Category: Mowbray, S L.]]
[[Category: Mowbray, S L.]]
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[[Category: chemotaxis]]
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[[Category: Chemotaxis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 13:52:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:46:15 2008''
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Revision as of 10:52, 30 April 2008

Template:STRUCTURE 1dpp

DIPEPTIDE BINDING PROTEIN COMPLEX WITH GLYCYL-L-LEUCINE


Overview

The Escherichia coli periplasmic dipeptide binding protein functions in both peptide transport and taxis toward peptides. The structure of the dipeptide binding protein in complex with Gly-Leu (glycyl-L-leucine) has been determined at 3.2 A resolution. The binding site for dipeptides is designed to recognize the ligand's backbone while providing space to accommodate a variety of side chains. Some repositioning of protein side chains lining the binding site must occur when the dipeptide's second residue is larger than leucine. The protein's fold is very similar to that of the Salmonella typhimurium oligopeptide binding protein, and a comparison of the structures reveals the structural basis for the dipeptide binding protein's preference for shorter peptides.

About this Structure

1DPP is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of the dipeptide binding protein from Escherichia coli involved in active transport and chemotaxis., Dunten P, Mowbray SL, Protein Sci. 1995 Nov;4(11):2327-34. PMID:8563629 Page seeded by OCA on Wed Apr 30 13:52:43 2008

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