1htt

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[[Image:1htt.gif|left|200px]]
[[Image:1htt.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1htt |SIZE=350|CAPTION= <scene name='initialview01'>1htt</scene>, resolution 2.6&Aring;
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The line below this paragraph, containing "STRUCTURE_1htt", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=S1A:HIS+And+Atp+Binding+Sites,+Product+Of+First+Reaction+(In+...'>S1A</scene>, <scene name='pdbsite=S1B:HIS+And+Atp+Binding+Sites,+Product+Of+First+Reaction+(In+...'>S1B</scene>, <scene name='pdbsite=S1C:HIS+And+Atp+Binding+Sites,+Product+Of+First+Reaction+(In+...'>S1C</scene> and <scene name='pdbsite=S1D:HIS+And+Atp+Binding+Sites,+Product+Of+First+Reaction+(In+...'>S1D</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Histidine--tRNA_ligase Histidine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.21 6.1.1.21] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1htt| PDB=1htt | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1htt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1htt OCA], [http://www.ebi.ac.uk/pdbsum/1htt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1htt RCSB]</span>
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}}
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'''HISTIDYL-TRNA SYNTHETASE'''
'''HISTIDYL-TRNA SYNTHETASE'''
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[[Category: Moras, D.]]
[[Category: Moras, D.]]
[[Category: Rees, B.]]
[[Category: Rees, B.]]
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[[Category: aminoacyl-trna synthase]]
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[[Category: Aminoacyl-trna synthase]]
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[[Category: complex (trna synthetase/his-adenylate)]]
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[[Category: Ligase]]
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[[Category: ligase]]
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[[Category: Synthetase]]
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[[Category: synthetase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 13:53:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:10:19 2008''
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Revision as of 10:53, 30 April 2008

Image:1htt.gif

Template:STRUCTURE 1htt

HISTIDYL-TRNA SYNTHETASE


Overview

The crystal structure at 2.6 A of the histidyl-tRNA synthetase from Escherichia coli complexed with histidyl-adenylate has been determined. The enzyme is a homodimer with a molecular weight of 94 kDa and belongs to the class II of aminoacyl-tRNA synthetases (aaRS). The asymmetric unit is composed of two homodimers. Each monomer consists of two domains. The N-terminal catalytic core domain contains a six-stranded antiparallel beta-sheet sitting on two alpha-helices, which can be superposed with the catalytic domains of yeast AspRS, and GlyRS and SerRS from Thermus thermophilus with a root-mean-square difference on the C alpha atoms of 1.7-1.9 A. The active sites of all four monomers are occupied by histidyl-adenylate, which apparently forms during crystallization. The 100 residue C-terminal alpha/beta domain resembles half of a beta-barrel, and provides an independent domain oriented to contact the anticodon stem and part of the anticodon loop of tRNA(His). The modular domain organization of histidyl-tRNA synthetase reiterates a repeated theme in aaRS, and its structure should provide insight into the ability of certain aaRS to aminoacylate minihelices and other non-tRNA molecules.

About this Structure

1HTT is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of histidyl-tRNA synthetase from Escherichia coli complexed with histidyl-adenylate., Arnez JG, Harris DC, Mitschler A, Rees B, Francklyn CS, Moras D, EMBO J. 1995 Sep 1;14(17):4143-55. PMID:7556055 Page seeded by OCA on Wed Apr 30 13:53:14 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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