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Mitogen-activated protein kinase
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<scene name='43/438476/Cv/5'>Inhibitors of MAPK bind in its ATP-binding site</scene><ref>PMID:17300186</ref>. Water molecule are shown as red sphere. | <scene name='43/438476/Cv/5'>Inhibitors of MAPK bind in its ATP-binding site</scene><ref>PMID:17300186</ref>. Water molecule are shown as red sphere. | ||
| + | |||
| + | == 3D Structures of Mitogen-activated protein kinase == | ||
| + | [[Mitogen-activated protein kinase 3D structures]] | ||
| + | |||
</StructureSection> | </StructureSection> | ||
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | *MAPK1 | + | *MAPK1 or ERK2 |
| + | |||
**[[4g6n]], [[4g6o]], [[4gsb]] – hMAPK1 - human<br /> | **[[4g6n]], [[4g6o]], [[4gsb]] – hMAPK1 - human<br /> | ||
| - | **[[3i5z]], [[3i60]], [[3w55]], [[2ojg]], [[2oji]], [[2ojj]], [[1wzy]], [[1tvo]], [[3sa0]], [[4fux]], [[4fuy]], [[4fv0]], [[4fv1]], [[4fv2]], [[4fv3]], [[4fv4]], [[4fv5]], [[4fv6]], [[4fv7]], [[4fv8]], [[4fv9]], [[4n4s]], [[4o6e]], [[4qp1]], [[4qp2]], [[4qp3]], [[4qp4]], [[4qp6]], [[4qp7]], [[4qp8]], [[4qp9]] [[4qpa]], [[4qta]], [[4qte]], [[4xj0]], [[4xne]], [[4xoy]], [[4xoz]], [[4xp0]], [[4xp2]], [[4xp3]], [[4xrj]], [[4xrl]], [[4zzm]], [[4zzn]], [[4zzo]], [[5bue]], [[5bui]], [[5buj]], [[5bvd]], [[5bve]], [[5bvf]], [[5hd4]], [[5hd7]], [[5k4i]], [[5ke0]], [[5lcj]], [[5lck]], [[5ngu]], [[5nhf]], [[5nhh]], [[5nhj]], [[5nhl]], [[5nho]], [[5nhp]], [[5nhv]], [[5u6i]], [[6g8x]], [[6g91]], [[6g92]], [[6g93]], [[6g97]], [[6g9a]], [[6g9d]], [[6g9h]], [[6g9j]], [[6g9k]], [[6g9m]], [[6g9n]], [[6gdm]], [[6gdq]], [[6ge0]], [[6dcg]], [[5wp1]] | + | **[[3i5z]], [[3i60]], [[3w55]], [[2ojg]], [[2oji]], [[2ojj]], [[1wzy]], [[1tvo]], [[3sa0]], [[4fux]], [[4fuy]], [[4fv0]], [[4fv1]], [[4fv2]], [[4fv3]], [[4fv4]], [[4fv5]], [[4fv6]], [[4fv7]], [[4fv8]], [[4fv9]], [[4n4s]], [[4o6e]], [[4qp1]], [[4qp2]], [[4qp3]], [[4qp4]], [[4qp6]], [[4qp7]], [[4qp8]], [[4qp9]] [[4qpa]], [[4qta]], [[4qte]], [[4xj0]], [[4xne]], [[4xoy]], [[4xoz]], [[4xp0]], [[4xp2]], [[4xp3]], [[4xrj]], [[4xrl]], [[4zzm]], [[4zzn]], [[4zzo]], [[5bue]], [[5bui]], [[5buj]], [[5bvd]], [[5bve]], [[5bvf]], [[5hd4]], [[5hd7]], [[5k4i]], [[5ke0]], [[5lcj]], [[5lck]], [[5ngu]], [[5nhf]], [[5nhh]], [[5nhj]], [[5nhl]], [[5nho]], [[5nhp]], [[5nhv]], [[5u6i]], [[6g8x]], [[6g91]], [[6g92]], [[6g93]], [[6g97]], [[6g9a]], [[6g9d]], [[6g9h]], [[6g9j]], [[6g9k]], [[6g9m]], [[6g9n]], [[6gdm]], [[6gdq]], [[6ge0]], [[6dcg]], [[5wp1]], [[6qaw]], [[6qaq]], [[6qal]], [[6qah]], [[6qag]], [[6qa4]], [[6qa3]], [[6qa1]], [[6q7t]], [[6q7s]], [[6q7k]], [[6nbs]], [[6gjd]], [[6gjb]], [[6ge0]], [[6gdq]], [[6gdm]], [[6g9n]], [[6g9m]], [[6g9j]], [[6g9k]], [[6g9h]], [[6g9d]], [[6g9a]], [[6g97]], [[6g93]], [[6g92]], [[6g91]], [[6g8x]], [[6g54]] – hMAPK1+inhibitor - human<br /> |
**[[2y9q]] – hMAPK1 + MAP kinase-interacting Ser/Thr protein kinase peptide<br /> | **[[2y9q]] – hMAPK1 + MAP kinase-interacting Ser/Thr protein kinase peptide<br /> | ||
**[[3tei]], [[4h3p]], [[4nif]] – hMAPK1 (mutant) + ribosomal protein S6 kinase α-1<br /> | **[[3tei]], [[4h3p]], [[4nif]] – hMAPK1 (mutant) + ribosomal protein S6 kinase α-1<br /> | ||
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**[[4zxt]] – hMAPK1 + catechol<br /> | **[[4zxt]] – hMAPK1 + catechol<br /> | ||
**[[5v60]] – hMAPK1 + ACP<br /> | **[[5v60]] – hMAPK1 + ACP<br /> | ||
| - | **[[ | + | **[[6opg]] – hMAPK1 + AMPPNP<br /> |
| - | **[[1erk]], [[4s31]], [[5umo]] - rMAPK1<br /> | + | **[[1erk]], [[4s31]], [[5umo]] - rMAPK1 - rat<br /> |
**[[1gol]], [[3r63]], [[4s2z]], [[4s30]] - rMAPK1 (mutant)<br /> | **[[1gol]], [[3r63]], [[4s2z]], [[4s30]] - rMAPK1 (mutant)<br /> | ||
| + | **[[2z7l]], [[3c9w]], [[3qyw]], [[3qyz]], [[4qyy]], [[6cpw]], [[6opk]], [[6opi]], [[6oph]], [[6fxv]], [[6frp]], [[6fr1]], [[6fq7]], [[6fn5]], [[6fma]], [[6flv]], [[6fle]], [[6fjz]], [[6fjb]], [[6fj0]], [[6fi6]], [[6fi3]] - rMAPK1+inhibitor <br /> | ||
**[[2gph]] - rMAPK1 (mutant)+HEPTP (mutant)<br /> | **[[2gph]] - rMAPK1 (mutant)+HEPTP (mutant)<br /> | ||
**[[3o71]] - rMAPK1 + colorectal cancer peptide<br /> | **[[3o71]] - rMAPK1 + colorectal cancer peptide<br /> | ||
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**[[3erk]], [[4erk]] – rMAPK2+inhibitor<br /> | **[[3erk]], [[4erk]] – rMAPK2+inhibitor<br /> | ||
| - | *MAPK3 | + | *MAPK3 or ERK1 |
**[[2zoq]] – hMAPK3<br /> | **[[2zoq]] – hMAPK3<br /> | ||
| - | **[[3r1n]], [[3she]], [[4qtb]] – hMAPK3 kinase domain +inhibitor<br /> | + | **[[3r1n]], [[3she]], [[4qtb]], [[3fxw]], [[3fhr]], [[6ges]] – hMAPK3 kinase domain +inhibitor<br /> |
*MAPK6 | *MAPK6 | ||
| - | **[[3fxw]], [[3fhr]] – hMAPK3 kinase domain +inhibitor<br /> | ||
**[[2i6l]] – hMAPK6<br /> | **[[2i6l]] – hMAPK6<br /> | ||
| - | *MAPK7 | + | *MAPK7 or ERK5 kinase domain |
**[[4ic8]] – hMAPK7<br /> | **[[4ic8]] – hMAPK7<br /> | ||
| - | **[[4b99]], [[4zsg]], [[4zsj]], [[4zsl]], [[5byy]], [[5byz]], [[5o7i]] | + | **[[4b99]], [[4zsg]], [[4zsj]], [[4zsl]], [[5byy]], [[5byz]], [[5o7i]], [[6hkn]], [[6hkm]] – hMAPK7+inhibitor<br /> |
**[[4ic7]] – hMAPK7+ MAP2K 5<br /> | **[[4ic7]] – hMAPK7+ MAP2K 5<br /> | ||
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**[[2lgc]] – hMAPK14 – NMR<br /> | **[[2lgc]] – hMAPK14 – NMR<br /> | ||
**[[3od6]], [[3ody]], [[3odz]], [[3oef]], [[3p4k]], [[2fsl]], [[2fsm]], [[2fso]], [[2fst]], [[1r3c]], [[4e5a]], [[4geo]] – hMAPK14 (mutant)<br /> | **[[3od6]], [[3ody]], [[3odz]], [[3oef]], [[3p4k]], [[2fsl]], [[2fsm]], [[2fso]], [[2fst]], [[1r3c]], [[4e5a]], [[4geo]] – hMAPK14 (mutant)<br /> | ||
| - | **[[3new]], [[3ocg]], [[3mvl]], [[3mvm]], [[3nnu]], [[3nnv]], [[3nnw]], [[3nnx]], [[3nww]], [[3mpt]], [[3lhj]], [[3huc]], [[3itz]], [[3l8x]], [[3kf7]], [[3fi4]], [[3fkl]], [[3fkn]], [[3fko]], [[3fl4]], [[3fln]], [[3flq]], [[3fls]], [[3flw]], [[3fly]], [[3flz]], [[3fmh]], [[3fmj]], [[3fmk]], [[3fml]], [[3flm]], [[3fln]], [[3fsf]], [[3fsk]], [[3kq7]], [[3iph]], [[3hv4]], [[3hv5]], [[3hv6]], [[3hv7]], [[3k3i]], [[3hec]], [[3heg]], [[3gi3]], [[3hp2]], [[3hp5]], [[3hrb]], [[3ha8]], [[3gfe]], [[3hl7]], [[3hll]], [[3gcu]], [[3fc1]], [[3dt1]], [[3e92]], [[3e93]], [[3d7z]], [[3d83]], [[3ctq]], [[2puu]], [[3bx5]], [[3c5u]], [[2zaz]], [[2zb0]], [[2zb1]], [[2qd9]], [[2ewa]], [[2gfs]], [[2baj]], [[2bak]], [[2bal]], [[2baq]], [[1zyj]], [[1wbn]], [[1wbs]], [[1wbt]], [[1wbv]], [[1wbw]], [[1zz2]], [[1zzl]], [[1yqj]], [[1w7h]], [[1w82]], [[1w83]], [[1w84]], [[1oz1]], [[1ouk]], [[1ouy]], [[1m7q]], [[1kv1]], [[1kv2]], [[1di9]], [[2rg5]], [[2rg6]], [[3bv3]], [[3bv2]], [[3fmm]], [[3fmn]], [[3lfa]], [[3mw1]], [[3pg3]], [[3roc]] ,[[2yis]], [[2yiw]], [[2yix]], [[3qud]], [[3que]], [[3rin]], [[3s3i]], [[3s4q]], [[3u8w]], [[3uvp]], [[3uvq]], [[3uvr]], [[3zs5]], [[3zsg]], [[3zsh]], [[3zsi]], [[3zya]], [[4a9y]], [[4aa0]], [[4aa4]], [[4aa5]], [[4aac]], [[4dli]], [[4dlj]], [[4e5b]], [[4eh2]], [[4eh3]], [[4eh4]], [[4eh5]], [[4eh6]], [[4eh7]], [[4eh8]], [[4eh9]], [[4ehv]], [[4ewq]], [[4f9w]], [[4f9y]], [[4fa2]], [[4kin]], [[4kip]], [[4kiq]], [[4l8m]], [[4r3c]], [[4zth]], [[5lar]], [[5ml5]], [[5tbe]], [[5tco]], [[6anl]], [[5xyy]], [[5xyx]] , [[5wjj]], [[5n68]], [[5n67]], [[5n66]], [[5n65]], [[5n64]], [[5n63]], [[5mz3]], [[5mty]], [[5mtx]], [[5o8v]], [[5o8u]] - hMAPK14+inhibitor<br /> | + | **[[3new]], [[3ocg]], [[3mvl]], [[3mvm]], [[3nnu]], [[3nnv]], [[3nnw]], [[3nnx]], [[3nww]], [[3mpt]], [[3lhj]], [[3huc]], [[3itz]], [[3l8x]], [[3kf7]], [[3fi4]], [[3fkl]], [[3fkn]], [[3fko]], [[3fl4]], [[3fln]], [[3flq]], [[3fls]], [[3flw]], [[3fly]], [[3flz]], [[3fmh]], [[3fmj]], [[3fmk]], [[3fml]], [[3flm]], [[3fln]], [[3fsf]], [[3fsk]], [[3kq7]], [[3iph]], [[3hv4]], [[3hv5]], [[3hv6]], [[3hv7]], [[3k3i]], [[3hec]], [[3heg]], [[3gi3]], [[3hp2]], [[3hp5]], [[3hrb]], [[3ha8]], [[3gfe]], [[3hl7]], [[3hll]], [[3gcu]], [[3fc1]], [[3dt1]], [[3e92]], [[3e93]], [[3d7z]], [[3d83]], [[3ctq]], [[2puu]], [[3bx5]], [[3c5u]], [[2zaz]], [[2zb0]], [[2zb1]], [[2qd9]], [[2ewa]], [[2gfs]], [[2baj]], [[2bak]], [[2bal]], [[2baq]], [[1zyj]], [[1wbn]], [[1wbs]], [[1wbt]], [[1wbv]], [[1wbw]], [[1zz2]], [[1zzl]], [[1yqj]], [[1w7h]], [[1w82]], [[1w83]], [[1w84]], [[1oz1]], [[1ouk]], [[1ouy]], [[1m7q]], [[1kv1]], [[1kv2]], [[1di9]], [[2rg5]], [[2rg6]], [[3bv3]], [[3bv2]], [[3fmm]], [[3fmn]], [[3lfa]], [[3mw1]], [[3pg3]], [[3roc]] ,[[2yis]], [[2yiw]], [[2yix]], [[3qud]], [[3que]], [[3rin]], [[3s3i]], [[3s4q]], [[3u8w]], [[3uvp]], [[3uvq]], [[3uvr]], [[3zs5]], [[3zsg]], [[3zsh]], [[3zsi]], [[3zya]], [[4a9y]], [[4aa0]], [[4aa4]], [[4aa5]], [[4aac]], [[4dli]], [[4dlj]], [[4e5b]], [[4eh2]], [[4eh3]], [[4eh4]], [[4eh5]], [[4eh6]], [[4eh7]], [[4eh8]], [[4eh9]], [[4ehv]], [[4ewq]], [[4f9w]], [[4f9y]], [[4fa2]], [[4kin]], [[4kip]], [[4kiq]], [[4l8m]], [[4r3c]], [[4zth]], [[5lar]], [[5ml5]], [[5tbe]], [[5tco]], [[6anl]], [[5xyy]], [[5xyx]] , [[5wjj]], [[5n68]], [[5n67]], [[5n66]], [[5n65]], [[5n64]], [[5n63]], [[5mz3]], [[5mty]], [[5mtx]], [[5o8v]], [[5o8u]], [[6sfo]], [[6sfk]], [[6sfj]], [[6sfi]], [[6m9l]], [[6m95]], [[6hwv]], [[6hwu]], [[6hwt]] - hMAPK14+inhibitor<br /> |
**[[4e6a]], [[4e6c]], [[4e8a]] - hMAPK14+ lipid<br /> | **[[4e6a]], [[4e6c]], [[4e8a]] - hMAPK14+ lipid<br /> | ||
**[[3o8t]], [[3mpa]], [[3obg]], [[3o8u]], [[3o8p]], [[3obj]], [[3oc1]], [[3hub]], [[3l8s]], [[3hv3]], [[3iw5]], [[3iw6]], [[3iw7]], [[3iw8]], [[3k3j]], [[3gc7]], [[3gcp]], [[3gcq]], [[3gcs]], [[3gcv]], [[3ds6]], [[2i0h]], [[1ove]], [[3lfb]], [[3lfc]], [[3lfd]], [[3lfe]], [[3lff]], [[1bl6]], [[1bl7]], [[1bmk]], [[1a9u]], [[1ian]] - hMAPK14 (mutant)+inhibitor<br /> | **[[3o8t]], [[3mpa]], [[3obg]], [[3o8u]], [[3o8p]], [[3obj]], [[3oc1]], [[3hub]], [[3l8s]], [[3hv3]], [[3iw5]], [[3iw6]], [[3iw7]], [[3iw8]], [[3k3j]], [[3gc7]], [[3gcp]], [[3gcq]], [[3gcs]], [[3gcv]], [[3ds6]], [[2i0h]], [[1ove]], [[3lfb]], [[3lfc]], [[3lfd]], [[3lfe]], [[3lff]], [[1bl6]], [[1bl7]], [[1bmk]], [[1a9u]], [[1ian]] - hMAPK14 (mutant)+inhibitor<br /> | ||
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**[[3tg1]] – hMAPK14 + MAPK phosphatase 5<br /> | **[[3tg1]] – hMAPK14 + MAPK phosphatase 5<br /> | ||
**[[5etf]] – hMAPK14 + MAPKK 6<br /> | **[[5etf]] – hMAPK14 + MAPKK 6<br /> | ||
| - | **[[2gtn]], [[2gtm]], [[3p5k]], [[3p78]], [[3p79]], [[3p7a]], [[3p7b]], [[3p7c]] - mMAPK14+inhibitor<br /> | + | **[[2gtn]], [[2gtm]], [[3p5k]], [[3p78]], [[3p79]], [[3p7a]], [[3p7b]], [[3p7c]], [[6spl]], [[6sp9]], [[6sov]], [[6sou]], [[6sot]], [[6soi]], [[6sod]], [[6so4]], [[6so2]], [[6so1]] - mMAPK14+inhibitor<br /> |
**[[2ghm]], [[2ghl]], [[1ywr]] - mMAPK14 (mutant)+inhibitor<br /> | **[[2ghm]], [[2ghl]], [[1ywr]] - mMAPK14 (mutant)+inhibitor<br /> | ||
**[[3py3]] - mMAPK14 phosphorylated<br /> | **[[3py3]] - mMAPK14 phosphorylated<br /> | ||
Revision as of 09:38, 31 October 2019
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3D Structures of Mitogen-activated protein kinase
Updated on 31-October-2019
References
- ↑ Robinson MJ, Cobb MH. Mitogen-activated protein kinase pathways. Curr Opin Cell Biol. 1997 Apr;9(2):180-6. PMID:9069255
- ↑ Aronov AM, Baker C, Bemis GW, Cao J, Chen G, Ford PJ, Germann UA, Green J, Hale MR, Jacobs M, Janetka JW, Maltais F, Martinez-Botella G, Namchuk MN, Straub J, Tang Q, Xie X. Flipped out: structure-guided design of selective pyrazolylpyrrole ERK inhibitors. J Med Chem. 2007 Mar 22;50(6):1280-7. Epub 2007 Feb 15. PMID:17300186 doi:http://dx.doi.org/10.1021/jm061381f
