Mitogen-activated protein kinase

== 3D Structures of Mitogen-activated protein kinase ==

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*MAPK1 or ERK2

**[[4g6n]], [[4g6o]], [[4gsb]] – hMAPK1 - human<br />

**[[3i5z]], [[3i60]], [[3w55]], [[2ojg]], [[2oji]], [[2ojj]], [[1wzy]], [[1tvo]], [[3sa0]], [[4fux]], [[4fuy]], [[4fv0]], [[4fv1]], [[4fv2]], [[4fv3]], [[4fv4]], [[4fv5]], [[4fv6]], [[4fv7]], [[4fv8]], [[4fv9]], [[4n4s]], [[4o6e]], [[4qp1]], [[4qp2]], [[4qp3]], [[4qp4]], [[4qp6]], [[4qp7]], [[4qp8]], [[4qp9]] [[4qpa]], [[4qta]], [[4qte]], [[4xj0]], [[4xne]], [[4xoy]], [[4xoz]], [[4xp0]], [[4xp2]], [[4xp3]], [[4xrj]], [[4xrl]], [[4zzm]], [[4zzn]], [[4zzo]], [[5bue]], [[5bui]], [[5buj]], [[5bvd]], [[5bve]], [[5bvf]], [[5hd4]], [[5hd7]], [[5k4i]], [[5ke0]], [[5lcj]], [[5lck]], [[5ngu]], [[5nhf]], [[5nhh]], [[5nhj]], [[5nhl]], [[5nho]], [[5nhp]], [[5nhv]], [[5u6i]], [[6g8x]], [[6g91]], [[6g92]], [[6g93]], [[6g97]], [[6g9a]], [[6g9d]], [[6g9h]], [[6g9j]], [[6g9k]], [[6g9m]], [[6g9n]], [[6gdm]], [[6gdq]], [[6ge0]], [[6dcg]], [[5wp1]], [[6qaw]], [[6qaq]], [[6qal]], [[6qah]], [[6qag]], [[6qa4]], [[6qa3]], [[6qa1]], [[6q7t]], [[6q7s]], [[6q7k]], [[6nbs]], [[6gjd]], [[6gjb]], [[6ge0]], [[6gdq]], [[6gdm]], [[6g9n]], [[6g9m]], [[6g9j]], [[6g9k]], [[6g9h]], [[6g9d]], [[6g9a]], [[6g97]], [[6g93]], [[6g92]], [[6g91]], [[6g8x]], [[6g54]] – hMAPK1+inhibitor - human<br />

**[[2y9q]] – hMAPK1 + MAP kinase-interacting Ser/Thr protein kinase peptide<br />

**[[3tei]], [[4h3p]], [[4nif]] – hMAPK1 (mutant) + ribosomal protein S6 kinase α-1<br />

**[[4iz5]], [[4iz7]], [[4iza]] – hMAPK1 (mutant) + astrocytic phosphoprotein <br />

**[[4fmq]] – hMAPK1 + MAPK docking peptide<br />

**[[5v62]], [[5v61]] – hMAPK1 + ERK2 peptide + inhibitor<br />

**[[4h3q]] – hMAPK1 + MAP2K 2 peptide<br />

**[[5ax3]] – hMAPK1 + allosteric inhibitor peptide<br />

**[[4n0s]] – hMAPK1 + cafeic acid<br />

**[[4zxt]] – hMAPK1 + catechol<br />

**[[5v60]] – hMAPK1 + ACP<br />

**[[6opg]] – hMAPK1 + AMPPNP<br />

**[[1erk]], [[4s31]], [[5umo]] - rMAPK1 - rat<br />

**[[1gol]], [[3r63]], [[4s2z]], [[4s30]] - rMAPK1 (mutant)<br />

**[[2z7l]], [[3c9w]], [[3qyw]], [[3qyz]], [[4qyy]], [[6cpw]], [[6opk]], [[6opi]], [[6oph]], [[6fxv]], [[6frp]], [[6fr1]], [[6fq7]], [[6fn5]], [[6fma]], [[6flv]], [[6fle]], [[6fjz]], [[6fjb]], [[6fj0]], [[6fi6]], [[6fi3]] - rMAPK1+inhibitor <br />

**[[2gph]] - rMAPK1 (mutant)+HEPTP (mutant)<br />

**[[3o71]] - rMAPK1 + colorectal cancer peptide<br />

**[[2fys]] - rMAPK1 + KIM peptide<br />

**[[4s32]] – rMAPK1 + AMPPNP<br />

**[[4s33]], [[4s34]] – rMAPK1 (mutant) + AMPPNP<br />

**[[4gt3]], [[4gva]] – rMAPK1 + nucleotide<br />

**[[4i5h]] – rMAPK1 (mutant) + inhibitor<br />

**[[3o71]] - rMAPK1 + colorectal cancer peptide<br />

**[[3zu7]], [[3zuv]] – rMAPK1 + ankyrin repeat protein<br />

**[[2y4i]] – raMAPK1+kinase suppressor of RAS 2 – rabbit<br />

**[[3oz6]] - MAPK1 - ''Cryptosporidium parvum''

*MAPK2

**[[1kwp]] – hMAPK2<br />

**[[3gok]] - hMAPK2 kinase domain<br />

**[[2pzy]], [[2p3g]], [[2jbo]], [[2jbp]] – hMAPK2 kinase domain +inhibitor<br />

**[[3a2c]], [[3kc3]], [[3fpm]], [[3fyj]], [[3fyk]], [[3r2b]], [[3r2y]], [[3r30]], [[3wi6]] - hMAPK2 kinase domain +inhibitor<br />

**[[3m2w]], [[3kga]], [[3ka0]], [[3m42]] – hMAPK2 kinase domain (mutant)+inhibitor<br />

**[[2oza]], [[2onl]] – hMAPK2+ hMAPK14<br />

**[[4tyh]] - hMAPK2+ hMAPK14 + inhibitor<br />

**[[1nxk]] – hMAPK2 + staurosporine<br />

**[[1ny3]] – hMAPK2 + ADP<br />

**[[2npt]] - hMAPK2 PHOX domain + hMAPK5<br />

**[[2erk]] – rMAPK2<br />

**[[3erk]], [[4erk]] – rMAPK2+inhibitor<br />

*MAPK3 or ERK1

**[[2zoq]] – hMAPK3<br />

**[[3r1n]], [[3she]], [[4qtb]], [[3fxw]], [[3fhr]], [[6ges]] – hMAPK3 kinase domain +inhibitor<br />

*MAPK6

**[[2i6l]] – hMAPK6<br />

*MAPK7 or ERK5 kinase domain

**[[4ic8]] – hMAPK7<br />

**[[4b99]], [[4zsg]], [[4zsj]], [[4zsl]], [[5byy]], [[5byz]], [[5o7i]], [[6hkn]], [[6hkm]] – hMAPK7+inhibitor<br />

**[[4ic7]] – hMAPK7+ MAP2K 5<br />

*MAPK8

**[[3o17]], [[2gmx]], [[2g01]], [[3vud]], [[3vug]], [[3vuh]], [[3vui]], [[3vuk]], [[3vul]], [[3vum]] – hMAPK8 (mutant)+JIP1 peptide<br />

**[[1ukh]], [[1uki]] - jMAPK8 JNK1+JIP1 peptide<br />

**[[6f5e]] - hMAPK8 JNK1+JIP1 peptide + darpin<br />

**[[5lw1]] - hMAPK8 JNK1+JIP1 peptide + darpin + pepstatin<br />

**[[3v3v]] - hMAPK8 JNK1+JIP1 peptide + quercedagetin<br />

**[[3o2m]] - hMAPK8 (mutant)+JIP1 peptide+biaryl tetrazole<br />

**[[2xrw]], [[2xs0]] - hMAPK8 + NFAT peptide<br />

**[[4ux9]] – hMAPK8 + MAPKK7 peptide<br />

**[[4yr8]] – hMAPK8 + MKP7 <br />

**[[3elj]], [[3pze]], [[4awi]], [[4l7f]], [[4qtd]] - hMAPK8+inhibitor<br />

**[[4e73]], [[4g1w]], [[4hys]], [[4hyu]], [[4izy]] – hMAPK8 + JIP1 +inhibitor<br />

**[[2no3]], [[2h96]] – hMAPK8 (mutant)+inhibitor<br />

*MAPK9

**[[3e7o]] - hMAPK9 (mutant)<br />

**[[3npc]] – hMAPK9 (mutant)+inhibitor<br />

*MAPK10

**[[3kvx]], [[3fv8]], [[2waj]], [[3fi2]], [[3fi3]], [[3da6]], [[2zdt]], [[2zdu]], [[3cgf]], [[3cgo]], [[2r9s]], [[2o0u]], [[2o2u]], [[2exc]], [[2b1p]], [[1pmn]], [[4z9l]], [[1pmu]], [[1pmv]], [[3oy1]], [[2ok1]], [[3ttj]], [[3tti]], [[3rtp]], [[3v6r]], [[3v6s]], [[4kkh]], [[4u79]], [[4whz]], [[4x21]], [[4y46]], [[4y5h]], [[3g9l]], [[3g90]], [[3g9n]], [[2p33]], [[6emh]], [[6ekd]] – hMAPK10 catalytic domain + inhibitor<br />

**[[3ptg]], [[4h39]] - hMAPK10 catalytic domain + JIP1 peptide <br />

**[[4h36]] – hMAPK10 catalytic domain + ATF2 peptide<br />

**[[4h3b]] – hMAPK10 catalytic domain + SAB peptide<br />

**[[4kke]], [[4kkg]] – hMAPK10 catalytic domain + AMPPNP<br />

**[[6eq9]] – hMAPK10 catalytic domain + ACP<br />

**[[3oxi]] - hMAPK10 + MAPK8 interacting protein + inhibitor<br />

*MAPK11

**[[3gp0]] – hMAPK11+inhibitor<br />

**[[3gc8]], [[3gc9]] – hMAPK11 (mutant)+inhibitor<br />

*MAPK13

**[[3coi]], [[4yno]], [[4myg]] – hMAPK13<br />

**[[4eyj]], [[4eym]], [[5ekn]], [[5eko]] - hMAPK13 +inhibitor<br />

*MAPK14

**[[3mgy]], [[3mh0]], [[3mh1]], [[3mh2]], [[3mh3]], [[3hvc]], [[3npq]], [[1wbo]], [[1r39]], [[2npq]], [[1wfc]], [[1cm8]], [[5etc]], [[5eti]], [[5uoj]] – hMAPK14<br />

**[[2lgc]] – hMAPK14 – NMR<br />

**[[3od6]], [[3ody]], [[3odz]], [[3oef]], [[3p4k]], [[2fsl]], [[2fsm]], [[2fso]], [[2fst]], [[1r3c]], [[4e5a]], [[4geo]] – hMAPK14 (mutant)<br />

**[[3new]], [[3ocg]], [[3mvl]], [[3mvm]], [[3nnu]], [[3nnv]], [[3nnw]], [[3nnx]], [[3nww]], [[3mpt]], [[3lhj]], [[3huc]], [[3itz]], [[3l8x]], [[3kf7]], [[3fi4]], [[3fkl]], [[3fkn]], [[3fko]], [[3fl4]], [[3fln]], [[3flq]], [[3fls]], [[3flw]], [[3fly]], [[3flz]], [[3fmh]], [[3fmj]], [[3fmk]], [[3fml]], [[3flm]], [[3fln]], [[3fsf]], [[3fsk]], [[3kq7]], [[3iph]], [[3hv4]], [[3hv5]], [[3hv6]], [[3hv7]], [[3k3i]], [[3hec]], [[3heg]], [[3gi3]], [[3hp2]], [[3hp5]], [[3hrb]], [[3ha8]], [[3gfe]], [[3hl7]], [[3hll]], [[3gcu]], [[3fc1]], [[3dt1]], [[3e92]], [[3e93]], [[3d7z]], [[3d83]], [[3ctq]], [[2puu]], [[3bx5]], [[3c5u]], [[2zaz]], [[2zb0]], [[2zb1]], [[2qd9]], [[2ewa]], [[2gfs]], [[2baj]], [[2bak]], [[2bal]], [[2baq]], [[1zyj]], [[1wbn]], [[1wbs]], [[1wbt]], [[1wbv]], [[1wbw]], [[1zz2]], [[1zzl]], [[1yqj]], [[1w7h]], [[1w82]], [[1w83]], [[1w84]], [[1oz1]], [[1ouk]], [[1ouy]], [[1m7q]], [[1kv1]], [[1kv2]], [[1di9]], [[2rg5]], [[2rg6]], [[3bv3]], [[3bv2]], [[3fmm]], [[3fmn]], [[3lfa]], [[3mw1]], [[3pg3]], [[3roc]] ,[[2yis]], [[2yiw]], [[2yix]], [[3qud]], [[3que]], [[3rin]], [[3s3i]], [[3s4q]], [[3u8w]], [[3uvp]], [[3uvq]], [[3uvr]], [[3zs5]], [[3zsg]], [[3zsh]], [[3zsi]], [[3zya]], [[4a9y]], [[4aa0]], [[4aa4]], [[4aa5]], [[4aac]], [[4dli]], [[4dlj]], [[4e5b]], [[4eh2]], [[4eh3]], [[4eh4]], [[4eh5]], [[4eh6]], [[4eh7]], [[4eh8]], [[4eh9]], [[4ehv]], [[4ewq]], [[4f9w]], [[4f9y]], [[4fa2]], [[4kin]], [[4kip]], [[4kiq]], [[4l8m]], [[4r3c]], [[4zth]], [[5lar]], [[5ml5]], [[5tbe]], [[5tco]], [[6anl]], [[5xyy]], [[5xyx]] , [[5wjj]], [[5n68]], [[5n67]], [[5n66]], [[5n65]], [[5n64]], [[5n63]], [[5mz3]], [[5mty]], [[5mtx]], [[5o8v]], [[5o8u]], [[6sfo]], [[6sfk]], [[6sfj]], [[6sfi]], [[6m9l]], [[6m95]], [[6hwv]], [[6hwu]], [[6hwt]] - hMAPK14+inhibitor<br />

**[[4e6a]], [[4e6c]], [[4e8a]] - hMAPK14+ lipid<br />

**[[3o8t]], [[3mpa]], [[3obg]], [[3o8u]], [[3o8p]], [[3obj]], [[3oc1]], [[3hub]], [[3l8s]], [[3hv3]], [[3iw5]], [[3iw6]], [[3iw7]], [[3iw8]], [[3k3j]], [[3gc7]], [[3gcp]], [[3gcq]], [[3gcs]], [[3gcv]], [[3ds6]], [[2i0h]], [[1ove]], [[3lfb]], [[3lfc]], [[3lfd]], [[3lfe]], [[3lff]], [[1bl6]], [[1bl7]], [[1bmk]], [[1a9u]], [[1ian]] - hMAPK14 (mutant)+inhibitor<br />

**[[2y8o]] – hMAPK14 (mutant) + dual specificity MAP2K peptide<br />

**[[4ka3]], [[4loo]], [[4lop]], [[4loq]] – hMAPK14 + docking peptide<br />

**[[5eta]] – hMAPK14 + peptide<br />

**[[3tg1]] – hMAPK14 + MAPK phosphatase 5<br />

**[[5etf]] – hMAPK14 + MAPKK 6<br />

**[[2gtn]], [[2gtm]], [[3p5k]], [[3p78]], [[3p79]], [[3p7a]], [[3p7b]], [[3p7c]], [[6spl]], [[6sp9]], [[6sov]], [[6sou]], [[6sot]], [[6soi]], [[6sod]], [[6so4]], [[6so2]], [[6so1]] - mMAPK14+inhibitor<br />

**[[2ghm]], [[2ghl]], [[1ywr]] - mMAPK14 (mutant)+inhibitor<br />

**[[3py3]] - mMAPK14 phosphorylated<br />

**[[1yw2]], [[5uoj]] - mMAPK14 (mutant)<br />

**[[1lew]] - mMAPK14+MEF2A<br />

**[[1lez]] - mMAPK14+MKK3B<br />

**[[5nzz]] – mMAPK14 + TGF <br />

**[[5o90]] – mMAPK14 (mutant) + TGF peptide<br />

*MAPK Fus3

**[[2f9g]], [[2b9f]] – yMAPK Fus3 – yeast<br />

**[[2fa2]] – yMAPK Fus3 (mutant)<br />

**[[2f49]] - yMAPK Fus3 +STE5 peptide<br />

**[[2b9h]], [[2b9i]] - yMAPK Fus3 (mutant)+MSG5 peptide<br />

**[[2b9j]] - yMAPK Fus3 (mutant)+FAR1 peptide<br />

*MAPK

**[[3rp9]] – MAPK – ''Toxoplasma gondii''<br />

**[[3uib]] – MAPK + inhibitor – ''Leishmania major''<br />

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