Monoclonal Antibodies 3D structures

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Line 32: Line 32:
**[[3hmw]] - hFab ustekinumab <br />
**[[3hmw]] - hFab ustekinumab <br />
**[[4k7p]] – hFab rhumab6 + mFab 10C4<br />
**[[4k7p]] – hFab rhumab6 + mFab 10C4<br />
 +
**[[6hud]] – hFab anti-amyloidosis – Cryo EM<br />
*Mouse Fab
*Mouse Fab
Line 87: Line 88:
**[[3p30]], [[2xra]] – hFab 1281 anti-HIV + gp41 ectodomain<br />
**[[3p30]], [[2xra]] – hFab 1281 anti-HIV + gp41 ectodomain<br />
**[[3ngb]] – hFab anti-HIV + glycoprotein gp120 <br />
**[[3ngb]] – hFab anti-HIV + glycoprotein gp120 <br />
 +
**[[6nc3]], [[6nc2]] – hFab anti-HIV + glycoprotein gp120 + glycoprotein gp41 – Cryo EM<br />
**[[3w9e]] – hFab anti-HIV 2 + glycoprotein D <br />
**[[3w9e]] – hFab anti-HIV 2 + glycoprotein D <br />
**[[4jo1]], [[4jo2]], [[4jo3]], [[4jo4]] - Fab anti-HIV R56 + gp120 - rabbit<br />
**[[4jo1]], [[4jo2]], [[4jo3]], [[4jo4]] - Fab anti-HIV R56 + gp120 - rabbit<br />
Line 211: Line 213:
**[[4f37]] – mFab anti-amyloid-β + colicin E7<br />
**[[4f37]] – mFab anti-amyloid-β + colicin E7<br />
**[[3gi8]], [[3gi9]] – mFab 7F11 + APCT transporter<br />
**[[3gi8]], [[3gi9]] – mFab 7F11 + APCT transporter<br />
-
**[[6cse]] – mFab + AGCS symporter + Ala<br />
+
**[[6cse]], [[6csf]] – mFab + AGCS symporter + Ala<br />
**[[3ffd]] – mFab + parathyroid hormone-related protein<br />
**[[3ffd]] – mFab + parathyroid hormone-related protein<br />
**[[2zuq]] – mFab + disulfide bond formation protein<br />
**[[2zuq]] – mFab + disulfide bond formation protein<br />
Line 264: Line 266:
*Fab: protein ternary complex
*Fab: protein ternary complex
-
**[[3bsz]] – mFab + transthyretin + retinol-binding protein<br />
+
**[[4cc8]] – hFab + gp41 + gp120<br />
-
**[[3ldb]] - CmFab + bifunctional arginine demethylase + α-ketogluterate<br />
+
**[[3j70]] – hFab + gp41 + gp120 + CD4<br />
 +
**[[4mxw]] – hFab anti-lymphotoxin-α + lymphotoxin-α + lymphotoxin-β + TNFR 3<br />
 +
**[[6mid]] – hFab + zika E protein + zika M protein<br />**[[3bsz]] – mFab + transthyretin + retinol-binding protein<br />
**[[2zck]] - mFab 8G8F5 + PSA + reaction intermediate<br />
**[[2zck]] - mFab 8G8F5 + PSA + reaction intermediate<br />
**[[3rhw]], [[3ri5]], [[3ria]], [[3rif]] – mFab + glutamate-gated Cl- channel + drug<br />
**[[3rhw]], [[3ri5]], [[3ria]], [[3rif]] – mFab + glutamate-gated Cl- channel + drug<br />
Line 278: Line 282:
**[[1yyl]], [[1yym]] - mFab + gp120 + CD4 mimic<br />
**[[1yyl]], [[1yym]] - mFab + gp120 + CD4 mimic<br />
**[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]], [[4z7q]], [[4z7o]], [[4z7n]] - mFab + integrin + peptide<br />
**[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]], [[4z7q]], [[4z7o]], [[4z7n]] - mFab + integrin + peptide<br />
-
**[[4cc8]] – hFab + gp41 + gp120<br />
+
**[[3ldb]] - CmFab + bifunctional arginine demethylase + α-ketogluterate<br />
-
**[[3j70]] – hFab + gp41 + gp120 + CD4<br />
+
-
**[[4mxw]] – hFab anti-lymphotoxin-α + lymphotoxin-α + lymphotoxin-β + TNFR 3<br />
+
-
**[[6mid]] – hFab + zika E protein + zika M protein<br />
+
*Full Immunoglobulin
*Full Immunoglobulin
 +
**[[1igy]] - hFab IgG1 <br />
**[[1igt]] – mFab IGG2A <br />
**[[1igt]] – mFab IGG2A <br />
-
**[[1igy]] - hFab IgG1 <br />
 
*Fc Fragments
*Fc Fragments
Line 299: Line 300:
*Catalytic antibody
*Catalytic antibody
-
**[[1kn2]], [[1kn4]], [[1yei]], [[1yej]], [[1yek]], [[1ngw]], [[1ngx]], [[1ngy]], [[1ngz]], [[1ct8]], [[2gfb]], [[1lo0]], [[1lo2]], [[1lo3]], [[1lo4]], [[1um4]], [[1um5]], [[1um6]], [[2gjz]], [[2gk0]], [[1f3d]], [[1ru9]], [[1rua]], [[1ruk]], [[1rul]], [[1rum]], [[1rup]], [[1ruq]], [[1rur]], [[2aju]], [[15c8]], [[2rcs]], [[1hq4]], [[1cf8]], [[1kem]], [[1yeh]], [[1yec]], [[1yed]], [[1yee]], [[1eap]], [[3bd3]], [[3bd4]], [[3bd5]], [[1jgu]], [[1jgv]], [[3cle]], [[3clf]], [[5xqw]], [[5i0z]] – mFab <br />
 
-
**[[1fl6]], [[1fl5]] – mFab 28B4 (mutant)<br />
 
-
**[[1mie]], [[1mj8]], [[1mju]], [[43c9]] – mFab esterolytic<br />
 
-
**[[1a4j]] - mFab Diels Alder<br />
 
**[[1hkl]], [[3zl4]], [[2agj]], [[1rhh]] – hFab<br />
**[[1hkl]], [[3zl4]], [[2agj]], [[1rhh]] – hFab<br />
**[[3o2v]] – hFab 1e9 (mutant)<br />
**[[3o2v]] – hFab 1e9 (mutant)<br />
Line 308: Line 305:
**[[1d5i]], [[1d5b]], [[1d6v]] - hmFab Oxy-cope<br />
**[[1d5i]], [[1d5b]], [[1d6v]] - hmFab Oxy-cope<br />
**[[1uwe]], [[1uwg]], [[3cfj]], [[3cfk]], [[1c5b]] – hmFab <br />
**[[1uwe]], [[1uwg]], [[3cfj]], [[3cfk]], [[1c5b]] – hmFab <br />
 +
**[[1kn2]], [[1kn4]], [[1yei]], [[1yej]], [[1yek]], [[1ngw]], [[1ngx]], [[1ngy]], [[1ngz]], [[1ct8]], [[2gfb]], [[1lo0]], [[1lo2]], [[1lo3]], [[1lo4]], [[1um4]], [[1um5]], [[1um6]], [[2gjz]], [[2gk0]], [[1f3d]], [[1ru9]], [[1rua]], [[1ruk]], [[1rul]], [[1rum]], [[1rup]], [[1ruq]], [[1rur]], [[2aju]], [[15c8]], [[2rcs]], [[1hq4]], [[1cf8]], [[1kem]], [[1yeh]], [[1yec]], [[1yed]], [[1yee]], [[1eap]], [[3bd3]], [[3bd4]], [[3bd5]], [[1jgu]], [[1jgv]], [[3cle]], [[3clf]], [[5xqw]], [[5i0z]] – mFab <br />
 +
**[[1fl6]], [[1fl5]] – mFab 28B4 (mutant)<br />
 +
**[[1mie]], [[1mj8]], [[1mju]], [[43c9]] – mFab esterolytic<br />
 +
**[[1a4j]] - mFab Diels Alder<br />
*Catalytic antibody complex
*Catalytic antibody complex
 +
**[[1gaf]], [[3fo0]], [[3fct]] - hFab + hapten<br />
 +
**[[3o2w]] – hFab (mutant) + transition state analog<br />
 +
**[[2xtj]] – hFab 1D05 + proprotein convertase subtilisin/kexin<br />
 +
**[[3t2n]] – hFab + serine protease hepsin<br />
 +
**[[3r1g]] – hFab + beta-secretase 1<br />
 +
**[[2j6e]] – hFab IGM + igG1 Fc<br />
 +
**[[1e4k]] - hFc Igg1 + Fc-γ-Riii Complex<br />
 +
**[[1y0l]], [[3fo1]], [[3fo2]], [[1c5c]] - hmFab + hapten<br />
**[[1n7m]] – mFab + methylmesoporphyrin<br />
**[[1n7m]] – mFab + methylmesoporphyrin<br />
**[[1wc7]] – mFab + phosphopyridoxyl alanine<br />
**[[1wc7]] – mFab + phosphopyridoxyl alanine<br />
Line 324: Line 333:
**[[4dw2]] – mFab + urokinase-type plasminogen activator<br />
**[[4dw2]] – mFab + urokinase-type plasminogen activator<br />
**[[1a3l]] – mFab 13G5 + inhibitor<br />
**[[1a3l]] – mFab 13G5 + inhibitor<br />
-
**[[1gaf]], [[3fo0]], [[3fct]] - hFab + hapten<br />
 
-
**[[3o2w]] – hFab (mutant) + transition state analog<br />
 
-
**[[2xtj]] – hFab 1D05 + proprotein convertase subtilisin/kexin<br />
 
-
**[[3t2n]] – hFab + serine protease hepsin<br />
 
-
**[[3r1g]] – hFab + beta-secretase 1<br />
 
-
**[[2j6e]] – hFab IGM + igG1 Fc<br />
 
-
**[[1e4k]] - hFc Igg1 + Fc-γ-Riii Complex<br />
 
-
**[[1y0l]], [[3fo1]], [[3fo2]], [[1c5c]] - hmFab + hapten<br />
 
* Single chain variable fragment (scFv)
* Single chain variable fragment (scFv)
**[[6ehy]], [[6ehx]], [[6ehw]], [[6ehv]], [[5j75]], [[5j74]], [[5c2b]], [[2a9n]], [[2a9m]] – hscFv<br />
**[[6ehy]], [[6ehx]], [[6ehw]], [[6ehv]], [[5j75]], [[5j74]], [[5c2b]], [[2a9n]], [[2a9m]] – hscFv<br />
 +
**[[5wn9]], [[4kv5]] – hscFv + peptide<br />
**[[1n4x]], [[1moe]], [[5vf2]], [[5i4f]], [[5b3n]], [[4nko]], [[4nkm]], [[4nkd]], [[4h0i]], [[4h0g]], [[4gqp]], [[3umt]], [[3nn8]] – mscFv<br />
**[[1n4x]], [[1moe]], [[5vf2]], [[5i4f]], [[5b3n]], [[4nko]], [[4nkm]], [[4nkd]], [[4h0i]], [[4h0g]], [[4gqp]], [[3umt]], [[3nn8]] – mscFv<br />
**[[4p49]], [[4p48]], [[4ouo]] – cscFv<br />
**[[4p49]], [[4p48]], [[4ouo]] – cscFv<br />
**[[5yy4]], [[5yd5]], [[5yd4]], [[5yd3]], [[5fxc]], [[5a2l]], [[5a2j]], [[4h0h]] – mscFv + peptide<br />
**[[5yy4]], [[5yd5]], [[5yd4]], [[5yd3]], [[5fxc]], [[5a2l]], [[5a2j]], [[4h0h]] – mscFv + peptide<br />
-
**[[5wn9]], [[4kv5]] – hscFv + peptide<br />
 
*scFv: protein complex
*scFv: protein complex
 +
**[[6ck9]] – hscFv + hFab + Gp41<br />
 +
**[[5uk2]], [[5uk1]], [[5uk0]], [[5ujz]], [[4yjz]] – hscFv + hemagglutinin<br />
 +
**[[5m2j]] – hscFv + TNF<br />
 +
**[[5jz7]] – hscFv + NGF<br />
 +
**[[5jym]], [[5jyl]] – hscFv + cadherin<br />
**[[5f3j]] – mscFv + Duffy receptor<br />
**[[5f3j]] – mscFv + Duffy receptor<br />
**[[6eqc]], [[5ogi]] – mscFv + hexon protein<br />
**[[6eqc]], [[5ogi]] – mscFv + hexon protein<br />
Line 351: Line 357:
**[[2znx]], [[1dzb]] – mscFv + lysozyme<br />
**[[2znx]], [[1dzb]] – mscFv + lysozyme<br />
**[[2kh2]] – mscFv + interleukin<br />
**[[2kh2]] – mscFv + interleukin<br />
-
**[[6ck9]] – hscFv + hFab + Gp41<br />
 
-
**[[5uk2]], [[5uk1]], [[5uk0]], [[5ujz]], [[4yjz]] – hscFv + hemagglutinin<br />
 
-
**[[5m2j]] – hscFv + TNF<br />
 
-
**[[5jz7]] – hscFv + NGF<br />
 
-
**[[5jym]], [[5jyl]] – hscFv + cadherin<br />
 
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 10:47, 31 October 2019

3D structures of Monoclonal Antibody

Updated on 31-October-2019

Humanized mouse antibody (hmFab) is a modified mFab which resembles more hFab.

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Jaime Prilusky, Joel L. Sussman

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