6qb4

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m (Protected "6qb4" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6qb4 is ON HOLD
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==Mcl1-scFv complex with an indole acid inhibitor==
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<StructureSection load='6qb4' size='340' side='right'caption='[[6qb4]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
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Authors: Hargreaves, D.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6qb4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QB4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QB4 FirstGlance]. <br>
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Description: Mcl1-scFv complex with an indole acid inhibitor
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HVN:3-[3-[[(1~{R})-1,2,3,4-tetrahydronaphthalen-1-yl]oxy]propyl]-7-(1,3,5-trimethylpyrazol-4-yl)-1~{H}-indole-2-carboxylic+acid'>HVN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6qb3|6qb3]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qb4 OCA], [http://pdbe.org/6qb4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qb4 RCSB], [http://www.ebi.ac.uk/pdbsum/6qb4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qb4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Hargreaves, D]]
[[Category: Hargreaves, D]]
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[[Category: Apoptosis]]
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[[Category: Indole acid]]
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[[Category: Mcl1]]
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[[Category: Scfv]]

Revision as of 06:47, 6 November 2019

Mcl1-scFv complex with an indole acid inhibitor

PDB ID 6qb4

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