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6rkw

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'''Unreleased structure'''
 
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The entry 6rkw is ON HOLD until Paper Publication
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==CryoEM structure of the complete E. coli DNA Gyrase complex bound to a 130 bp DNA duplex==
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<StructureSection load='6rkw' size='340' side='right'caption='[[6rkw]], [[Resolution|resolution]] 6.60&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6rkw]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RKW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RKW FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=JHN:(3~{R})-3-[[4-(3,4-dihydro-2~{H}-pyrano[2,3-c]pyridin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4,7-triazatricyclo[6.3.1.0^{4,12}]dodeca-6,8(12),9-triene-5,11-dione'>JHN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Isomerase Isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.6.2.3 5.6.2.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rkw OCA], [http://pdbe.org/6rkw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rkw RCSB], [http://www.ebi.ac.uk/pdbsum/6rkw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rkw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/GYRA_ECOLI GYRA_ECOLI]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.<ref>PMID:12051842</ref> <ref>PMID:18642932</ref> <ref>PMID:19965760</ref> [[http://www.uniprot.org/uniprot/GYRB_ECOLI GYRB_ECOLI]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.<ref>PMID:12051843</ref> <ref>PMID:18642932</ref> <ref>PMID:20675723</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Isomerase]]
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[[Category: Large Structures]]
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[[Category: Broeck, A Vanden]]
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[[Category: Lamour, V]]
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[[Category: Complex]]
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[[Category: Dna binding protein]]
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[[Category: Dna gyrase]]
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[[Category: Inhibitor]]

Revision as of 06:49, 6 November 2019

CryoEM structure of the complete E. coli DNA Gyrase complex bound to a 130 bp DNA duplex

PDB ID 6rkw

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