5vh0
From Proteopedia
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==RHCC in complex with pyrene== | ==RHCC in complex with pyrene== | ||
| - | <StructureSection load='5vh0' size='340' side='right' caption='[[5vh0]], [[Resolution|resolution]] 2.06Å' scene=''> | + | <StructureSection load='5vh0' size='340' side='right'caption='[[5vh0]], [[Resolution|resolution]] 2.06Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5vh0]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VH0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VH0 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5vh0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43588 Atcc 43588]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VH0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VH0 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8P0:pyrene'>8P0</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8P0:pyrene'>8P0</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vh0 OCA], [http://pdbe.org/5vh0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vh0 RCSB], [http://www.ebi.ac.uk/pdbsum/5vh0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vh0 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vh0 OCA], [http://pdbe.org/5vh0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vh0 RCSB], [http://www.ebi.ac.uk/pdbsum/5vh0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vh0 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Polycyclic aromatic hydrocarbons (PAHs) are toxic, mutagenic and among the most damaging chemical compounds with regard to living organisms. Because of their persistence and wide distribution removal from the environment is an important challenge. Here we report a new Nano container matrix based on the deep sea archaea-derived RHCC-Nanotube (RHCC-NT), which rapidly and preferentially binds low molecular weight PAHs. Under controlled-laboratory conditions and using fluorescence spectroscopy in combination with X-ray crystallography and MD simulations, we quantified the real-time binding of low molecular weight PAHs (2-4 rings) to our substrate. Binding coefficients ranged from 5.4 +/- 1.6 (fluorene) to 32 +/- 7.0 muM (acenaphthylene) and a binding capacity of 85 pmoles PAH per mg RHCC-NT, or 2.12 mumoles in a standard 25 mg sampler. The uptake rate of pyrene was calculated to be 1.59 nmol/hrmol RHCC-NT (at 10 C). Our results clearly show that RHCC-NT is uniquely suited as a monitoring matrix for low molecular weight PAHs. | ||
| + | |||
| + | Proteinaceous Nano container Encapsulate Polycyclic Aromatic Hydrocarbons.,McDougall M, Francisco O, Harder-Viddal C, Roshko R, Heide F, Sidhu S, Khajehpour M, Leslie J, Palace V, Tomy GT, Stetefeld J Sci Rep. 2019 Jan 31;9(1):1058. doi: 10.1038/s41598-018-37323-x. PMID:30705306<ref>PMID:30705306</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5vh0" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Atcc 43588]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Francisco, O]] | [[Category: Francisco, O]] | ||
[[Category: McDougall, M]] | [[Category: McDougall, M]] | ||
Revision as of 07:23, 6 November 2019
RHCC in complex with pyrene
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