5ztc
From Proteopedia
(Difference between revisions)
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<StructureSection load='5ztc' size='340' side='right'caption='[[5ztc]], [[Resolution|resolution]] 1.70Å' scene=''> | <StructureSection load='5ztc' size='340' side='right'caption='[[5ztc]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5ztc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZTC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZTC FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5ztc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lismo Lismo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZTC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZTC FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lmo2088 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=169963 LISMO])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ztc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ztc OCA], [http://pdbe.org/5ztc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ztc RCSB], [http://www.ebi.ac.uk/pdbsum/5ztc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ztc ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ztc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ztc OCA], [http://pdbe.org/5ztc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ztc RCSB], [http://www.ebi.ac.uk/pdbsum/5ztc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ztc ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Listeria monocytogenes is a gram-positive food borne pathogen. The lmo2088 belongs to the TetR family of transcriptional regulators from L. monocytogenes. These transcriptional factors regulate multidrug resistance transporters in L. monocytogenes. Here, we report native protein crystal structure of lmo2088 at a resolution of 1.7A. Lmo2088 comprises of an N-terminal DNA binding domain and a variable C-terminal effector binding domain. Furthermore, we identified specific consensus sequences selected by systematic evolution of ligands by exponential enrichment in vitro. The specific binding of lmo2088 with DNA consensus sequence was validated by electrophoretic mobility shift assay, fluorescence polarization and isothermal titration calorimetry. We speculate that the structure of lmo2088 might provide an insight into the regulatory function of lmo2088 of L. monocytogenes. | ||
| + | |||
| + | X-ray crystal structure of putative transcription regulator lmo2088 from Listeria monocytogenes.,Samad A, Li Y, Zhang C, Chen F, Zeng W, Fan X, Jin T Biochem Biophys Res Commun. 2019 Dec 3;520(2):434-440. doi:, 10.1016/j.bbrc.2019.10.033. Epub 2019 Oct 10. PMID:31607473<ref>PMID:31607473</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5ztc" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Lismo]] | ||
[[Category: Jin, T]] | [[Category: Jin, T]] | ||
[[Category: Samad, A]] | [[Category: Samad, A]] | ||
[[Category: Tetr family]] | [[Category: Tetr family]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
Revision as of 07:34, 6 November 2019
Apo structure of TetR family transcription regulator Lmo2088 of Listeria monocytogenes EGDe
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