Nucleoprotein

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*<scene name='46/461363/Cv/6'>TTP binding site</scene> in Nucleoprotein from Lassa virus ([[3mx2]]). Water molecules are shown as red spheres.
*<scene name='46/461363/Cv/6'>TTP binding site</scene> in Nucleoprotein from Lassa virus ([[3mx2]]). Water molecules are shown as red spheres.
*<scene name='46/461363/Cv/7'>Zn coordination site</scene>.
*<scene name='46/461363/Cv/7'>Zn coordination site</scene>.
 +
 +
== 3D Structures of Nucleoprotein ==
 +
[[Nucleoprotein 3D structures]]
 +
</StructureSection>
</StructureSection>
== 3D Structures of Nucleoprotein ==
== 3D Structures of Nucleoprotein ==
Line 26: Line 30:
**[[2k48]] – AvNP N terminal - NMR<br />
**[[2k48]] – AvNP N terminal - NMR<br />
**[[1ssk]] - ScvNP N terminal – SARS coronavirus – NMR<br />
**[[1ssk]] - ScvNP N terminal – SARS coronavirus – NMR<br />
 +
**[[6g13]] - NP C terminal – MERS coronavirus<br />
**[[4j3k]], [[5n4k]] – ScvNP N terminal<br />
**[[4j3k]], [[5n4k]] – ScvNP N terminal<br />
**[[5epw]] – ScvNP C terminal<br />
**[[5epw]] – ScvNP C terminal<br />
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**[[3zdp]], [[4dyt]] – IvNP (mutant)<br />
**[[3zdp]], [[4dyt]] – IvNP (mutant)<br />
**[[2q06]], [[2iqh]], [[3tj0]], [[4dys]], [[4iry]], [[5b7b]], [[5n2u]] – IvNP<br />
**[[2q06]], [[2iqh]], [[3tj0]], [[4dys]], [[4iry]], [[5b7b]], [[5n2u]] – IvNP<br />
-
**[[6ehl]] - EvNP – Ebola virus – Cryo EM<br />
+
**[[6ehl]] - EvNP – Zaire Ebola virus – Cryo EM<br />
**[[6c54]] - EvNP residues 25-457- Cryo EM<br />
**[[6c54]] - EvNP residues 25-457- Cryo EM<br />
**[[2i8b]] – EvNP C terminal – Ebola virus – NMR<br />
**[[2i8b]] – EvNP C terminal – Ebola virus – NMR<br />
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**[[1n93]], [[1pp1]] – NP P40 – Borna disease virus<br />
**[[1n93]], [[1pp1]] – NP P40 – Borna disease virus<br />
**[[4aqf]], [[4aqg]] – NP N – Crimean-Congo hemorrhagic fever virus<br />
**[[4aqf]], [[4aqg]] – NP N – Crimean-Congo hemorrhagic fever virus<br />
-
**[[4fi5]] – NP N terminal – Hantaan virus<br />
+
**[[4fi5]] – HavNP N terminal – Hantaan virus<br />
**[[4bgp]] – LcvNP – La crosse virus<br />
**[[4bgp]] – LcvNP – La crosse virus<br />
**[[4gve]] – NP C terminal – Tacaribe virus<br />
**[[4gve]] – NP C terminal – Tacaribe virus<br />
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**[[4uce]], [[4ucd]], [[4uc7]], [[4uc6]] – RsvNP N terminal – Human respiratory syncytial virus<br />
**[[4uce]], [[4ucd]], [[4uc7]], [[4uc6]] – RsvNP N terminal – Human respiratory syncytial virus<br />
-
*Nucleoprotein complex
+
*Nucleoprotein complex with RNA
-
**[[3mx2]], [[3mx5]] – LvNP + nucleotide<br />
 
**[[3t5n]], [[3t5q]], [[4fvu]], [[4g9z]], [[4gv3]], [[4gv6]], [[4gv9]] – LvNP + RNA<br />
**[[3t5n]], [[3t5q]], [[4fvu]], [[4g9z]], [[4gv3]], [[4gv6]], [[4gv9]] – LvNP + RNA<br />
**[[3ptx]], [[3pu0]], [[3pu1]], [[3pu4]], [[2gic]] – VvNP + RNA<br />
**[[3ptx]], [[3pu0]], [[3pu1]], [[3pu4]], [[2gic]] – VvNP + RNA<br />
**[[6bjy]] - VvNP + inhibitor + RNA<br />
**[[6bjy]] - VvNP + inhibitor + RNA<br />
-
**[[2wyy]] – VvNP + poly U – Cryo EM<br />
 
-
**[[3hhw]], [[3pmk]] – VvNP + phosphoprotein<br />
 
**[[3hhz]] - VvNP + phosphoprotein + RNA<br />
**[[3hhz]] - VvNP + phosphoprotein + RNA<br />
**[[5uk4]] - VvNP + nanobody + RNA<br />
**[[5uk4]] - VvNP + nanobody + RNA<br />
-
**[[4co6]] - NP + phosphoprotein – Nipah virus<br />
 
**[[2wj8]], [[2yhm]], [[4bkk]] – RsvNP + RNA <br />
**[[2wj8]], [[2yhm]], [[4bkk]] – RsvNP + RNA <br />
-
**[[4ucc]] – RsvNP N terminal + inhibitor<br />
 
-
**[[4ucb]], [[4uca]] – RsvNP N terminal + phosphoprotein<br />
 
-
**[[4uc9]], [[4uc8]] – RsvNP N terminal + phosphoprotein peptidebr />
 
**[[2i91]], [[1yvp]] – XlNP Ro + RNA <br />
**[[2i91]], [[1yvp]] – XlNP Ro + RNA <br />
**[[2gtt]] – NP + RNA – Rabies virus<br />
**[[2gtt]] – NP + RNA – Rabies virus<br />
**[[1wwg]], [[1wwd]], [[1wwe]], [[1u6p]] - MvNP P10 + RNA – NMR<br />
**[[1wwg]], [[1wwd]], [[1wwe]], [[1u6p]] - MvNP P10 + RNA – NMR<br />
-
**[[3ro5]], [[4dya]], [[4dyb]], [[4dyn]], [[4dyp]], [[3tg6]] – IvNP + ligand<br />
 
**[[4bbl]] – IvNP + RNA – Cryo EM<br />
**[[4bbl]] – IvNP + RNA – Cryo EM<br />
-
**[[5tjw]] - IvNP + nanobody <br />
 
**[[3zla]] – BvNP + RNA – Bunyamwera virus<br />
**[[3zla]] – BvNP + RNA – Bunyamwera virus<br />
**[[4ijs]] – BvNP (mutant) + RNA <br />
**[[4ijs]] – BvNP (mutant) + RNA <br />
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**[[4jng]] – SvNP + RNA <br />
**[[4jng]] – SvNP + RNA <br />
**[[4j1g]], [[4j1j]] – NP + RNA – Leanye virus<br />
**[[4j1g]], [[4j1j]] – NP + RNA – Leanye virus<br />
 +
**[[5ip2]] - TsvNP + RNA <br />
 +
**[[5fvc]] - HmpvNP + RNA – Human metapneumovirus<br />
 +
**[[4xjn]] - PivNP + RNA – Parainfluenza virus<br />
 +
**[[6i2n]] - HavNP + RNA – Cryo EM<br />
 +
**[[6h5s]] - MevNP + RNA – Measles virus - Cryo EM<br />
 +
**[[6nut]], [[5z9w]] - EvNP + RNA – Cryo EM<br />
 +
 +
*Nucleoprotein complex with antibody
 +
 +
**[[5uk4]] - VvNP + nanobody + RNA<br />
 +
**[[5tjw]] - IvNP + nanobody <br />
 +
**[[6app]], [[4w2q]], [[4w2o]] - LvmvNP C-terminal + nanobody <br />
 +
**[[5w2b]] - NP + antibody – Reston Ebolavirus<br />
 +
**[[5vkd]] - NP C-terminal + antibody – Bundibugyo Ebolavirus<br />
 +
**[[6u55]], [[6u54]], [[6u52]], [[6u51]] - NP C-terminal + antibody – Sudan Ebolavirus<br />
 +
 +
*Nucleoprotein other complexes
 +
 +
**[[3mx2]], [[3mx5]] – LvNP + nucleotide<br />
 +
**[[2wyy]] – VvNP + poly U – Cryo EM<br />
 +
**[[3hhw]], [[3pmk]] – VvNP + phosphoprotein<br />r />
 +
**[[4co6]] - NP + phosphoprotein – Nipah virus<br />
 +
**[[4ucc]] – RsvNP N terminal + inhibitor<br />
 +
**[[4ucb]], [[4uca]] – RsvNP N terminal + phosphoprotein<br />
 +
**[[4uc9]], [[4uc8]] – RsvNP N terminal + phosphoprotein peptide<br />
 +
**[[3ro5]], [[4dya]], [[4dyb]], [[4dyn]], [[4dyp]], [[3tg6]] – IvNP + ligand<br />
**[[4kxj]] – ScvNP N terminal + PJ34 <br />
**[[4kxj]] – ScvNP N terminal + PJ34 <br />
**[[4li4]], [[4lm7]], [[4lm9]], [[4lmc]] – ScvNP N terminal + nucleotide <br />
**[[4li4]], [[4lm7]], [[4lm9]], [[4lmc]] – ScvNP N terminal + nucleotide <br />
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**[[5sxq]], [[5f5o]] - LvmvNP + VP35 peptide <br />
**[[5sxq]], [[5f5o]] - LvmvNP + VP35 peptide <br />
**[[5ip3]] - TsvNP + DNA <br />
**[[5ip3]] - TsvNP + DNA <br />
-
**[[5ip2]] - TsvNP + RNA <br />
 
-
**[[5fvc]] - HmpvNP + RNA – Human metapneumovirus<br />
 
**[[5fvd]] - HmpvNP + phosphoprotein<br />
**[[5fvd]] - HmpvNP + phosphoprotein<br />
-
**[[4xjn]] - PivNP + RNA – Parainfluenza virus<br />
 
**[[5wkn]] - PivNP + phosphoprotein<br />
**[[5wkn]] - PivNP + phosphoprotein<br />
-
**[[6app]], [[4w2q]], [[4w2o]] - LvmvNP C-terminal + nanobody <br />
 
-
**[[5w2b]] - NP + antibody – Reston Ebolavirus<br />
 
-
**[[5vkd]] - NP C-terminal + antibody – Bundibugyo Ebolavirus<br />
 
*'''Ribonucleoprotein'''
*'''Ribonucleoprotein'''
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**[[4h5l]], [[4csg]], [[5fva]] – TvRNP – Toscana virus<br />
**[[4h5l]], [[4csg]], [[5fva]] – TvRNP – Toscana virus<br />
**[[4csf]] – TvRNP + RNA<br />
**[[4csf]] – TvRNP + RNA<br />
-
**[[4uft]] – RNP + RNA – Measles virus<br />
+
**[[4uft]] – MevRNP + RNA <br />
*'''Small nuclear ribonucleoprotein'''
*'''Small nuclear ribonucleoprotein'''

Revision as of 11:28, 11 November 2019

Nucleoprotein from Lassa virus trimer complex with TTP and Zn+2 ions (grey) 3mx2

Drag the structure with the mouse to rotate

3D Structures of Nucleoprotein

Updated on 11-November-2019

References

  1. ↑ Echols H. Nucleoprotein structures initiating DNA replication, transcription, and site-specific recombination. J Biol Chem. 1990 Sep 5;265(25):14697-700. PMID:2203758
  2. ↑ Yong J, Wan L, Dreyfuss G. Why do cells need an assembly machine for RNA-protein complexes? Trends Cell Biol. 2004 May;14(5):226-32. PMID:15130578 doi:http://dx.doi.org/10.1016/j.tcb.2004.03.010
  3. ↑ He Y, Smith R. Nuclear functions of heterogeneous nuclear ribonucleoproteins A/B. Cell Mol Life Sci. 2009 Apr;66(7):1239-56. doi: 10.1007/s00018-008-8532-1. PMID:19099192 doi:http://dx.doi.org/10.1007/s00018-008-8532-1

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman

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