Nucleoprotein

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Nucleoprotein from Lassa virus trimer complex with TTP and Zn+2 ions (grey) 3mx2

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References

↑ Echols H. Nucleoprotein structures initiating DNA replication, transcription, and site-specific recombination. J Biol Chem. 1990 Sep 5;265(25):14697-700. PMID:2203758
↑ Yong J, Wan L, Dreyfuss G. Why do cells need an assembly machine for RNA-protein complexes? Trends Cell Biol. 2004 May;14(5):226-32. PMID:15130578 doi:http://dx.doi.org/10.1016/j.tcb.2004.03.010
↑ He Y, Smith R. Nuclear functions of heterogeneous nuclear ribonucleoproteins A/B. Cell Mol Life Sci. 2009 Apr;66(7):1239-56. doi: 10.1007/s00018-008-8532-1. PMID:19099192 doi:http://dx.doi.org/10.1007/s00018-008-8532-1

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Nucleoprotein

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Revision as of 11:29, 11 November 2019

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3D Structures of Nucleoprotein

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 <StructureSection load='' size='350' side='right' caption='Nucleoprotein from Lassa virus trimer complex with TTP and Zn+2 ions (grey) [[3mx2]]' scene='46/461363/Cv/2' pspeed='8'>
+__TOC__
+== Function ==
 '''Nucleoproteins''' (NP) are proteins associated with DNA or RNA<ref>PMID:2203758</ref>.  NPs which contain RNA are called '''ribonucleoproteins''' (RNPs).  The NP RNA-recognition motif is named RRM.<br />
@@ Line 15: / Line 18: @@
 </StructureSection>
-== 3D Structures of Nucleoprotein ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*'''Nucleoprotein'''
-**[[3ouo]], [[3ov9]] – NP – Rift valley fever virus<br />
-**[[3q7b]], [[3q7c]] – LvNP exonuclease domain – Lassa virus<br />
-**[[3mwp]], [[3mwt]], [[3r3l]] – LvNP<br />
-**[[3pto]] - VvNP – Vesicular stomatitis Indiana virus<br />
-**[[2qvj]] – VvNP (mutant)<br />
-**[[5e04]] - AvNP – Andes virus<br />
-**[[2k48]] – AvNP N terminal - NMR<br />
-**[[1ssk]] - ScvNP N terminal – SARS coronavirus – NMR<br />
-**[[6g13]] - NP C terminal – MERS coronavirus<br />
-**[[4j3k]], [[5n4k]] – ScvNP N terminal<br />
-**[[5epw]] – ScvNP C terminal<br />
-**[[2gib]] – ScvNP dimerization domain<br />
-**[[2jw8]] - ScvNP dimerization domain – NMR<br />
-**[[2ofz]], [[2og3]] - ScvNP RNA-binding domain<br />
-**[[3hd4]] – NP N terminal – Murine hepatitis virus<br />
-**[[2wfs]], [[2ymn]] – IvNP – Cryo EM – Influenza virus<br />
-**[[3zdp]], [[4dyt]] – IvNP (mutant)<br />
-**[[2q06]], [[2iqh]], [[3tj0]], [[4dys]], [[4iry]], [[5b7b]], [[5n2u]]  – IvNP<br />
-**[[6ehl]] - EvNP – Zaire Ebola virus – Cryo EM<br />
-**[[6c54]] - EvNP residues 25-457- Cryo EM<br />
-**[[2i8b]] – EvNP C terminal – Ebola virus – NMR<br />
-**[[3v7o]], [[4qaz]], [[4qb0]], [[5dsd]], [[5e2x]] - EvNP C terminal<br />
-**[[4z9p]] - EvNP core domain residues 36-351<br />
-**[[5dvw]] - EvNP V30 residues 142-272<br />
-**[[1yvr]] – XlNP Ro – ''Xenopus laevis''<br />
-**[[1wwf]] – MvNP P10 – Moloney murine leukemia virus – NMR<br />
-**[[2c86]], [[2gec]] – BvNP N terminal – Avian infectious bronchitis virus<br />
-**[[2ca1]], [[2ge7]], [[2ge8]] – BvNP dimerization domain<br />
-**[[2btl]], [[2bxx]] – BvNP RRM (mutant)<br />
-**[[1n93]], [[1pp1]] – NP P40 – Borna disease virus<br />
-**[[4aqf]], [[4aqg]] – NP N – Crimean-Congo hemorrhagic fever virus<br />
-**[[4fi5]] – HavNP N terminal – Hantaan virus<br />
-**[[4bgp]] – LcvNP – La crosse virus<br />
-**[[4gve]] – NP C terminal – Tacaribe virus<br />
-**[[4idu]], [[4idx]] – SvNP – Schmallenberg virus<br />
-**[[4k7e]] – NP C terminal – Junin virus<br />
-**[[4o6h]], [[4o6i]] – NP C terminal – Lymphocytic choriomeningitis virus<br />
-**[[5ls4]], [[5lrp]] – NP exonuclease domain – Mopeia virus<br />
-**[[5ip1]] - TsvNP - Tomato spotted virus<br />
-**[[5y6j]] - TsvNP (mutant)<br />
-**[[5f5m]] - LvmvNP – Lake Victoria Marburgvirus<br />
-**[[4xze]] - NP - Hazara virus<br />
-**[[4xzc]] - NP - Hupe virus<br />
-**[[4xza]], [[4xz8]] - NP - Erve virus<br />
-**[[4uce]], [[4ucd]], [[4uc7]], [[4uc6]] – RsvNP N terminal – Human respiratory syncytial virus<br />
-*Nucleoprotein complex with RNA
-**[[3t5n]], [[3t5q]], [[4fvu]], [[4g9z]], [[4gv3]], [[4gv6]], [[4gv9]] – LvNP + RNA<br />
-**[[3ptx]], [[3pu0]], [[3pu1]], [[3pu4]], [[2gic]] – VvNP + RNA<br />
-**[[6bjy]] - VvNP + inhibitor + RNA<br />
-**[[3hhz]] - VvNP + phosphoprotein + RNA<br />
-**[[5uk4]] - VvNP + nanobody + RNA<br />
-**[[2wj8]], [[2yhm]], [[4bkk]] – RsvNP + RNA <br />
-**[[2i91]], [[1yvp]] – XlNP Ro + RNA <br />
-**[[2gtt]] – NP + RNA – Rabies virus<br />
-**[[1wwg]], [[1wwd]], [[1wwe]], [[1u6p]] - MvNP P10 + RNA – NMR<br />
-**[[4bbl]] – IvNP + RNA – Cryo EM<br />
-**[[3zla]] – BvNP + RNA – Bunyamwera virus<br />
-**[[4ijs]] – BvNP (mutant) + RNA <br />
-**[[4bhh]] – LcvNP + poly-U<br />
-**[[4jng]] – SvNP + RNA <br />
-**[[4j1g]], [[4j1j]] – NP + RNA – Leanye virus<br />
-**[[5ip2]] - TsvNP + RNA <br />
-**[[5fvc]] - HmpvNP + RNA – Human metapneumovirus<br />
-**[[4xjn]] - PivNP + RNA – Parainfluenza virus<br />
-**[[6i2n]] - HavNP + RNA – Cryo EM<br />
-**[[6h5s]] - MevNP + RNA – Measles virus - Cryo EM<br />
-**[[6nut]], [[5z9w]] - EvNP + RNA – Cryo EM<br />
-*Nucleoprotein complex with antibody
-**[[5uk4]] - VvNP + nanobody + RNA<br />
-**[[5tjw]] - IvNP + nanobody <br />
-**[[6app]], [[4w2q]], [[4w2o]] - LvmvNP C-terminal + nanobody <br />
-**[[5w2b]] - NP + antibody – Reston Ebolavirus<br />
-**[[5vkd]] - NP C-terminal + antibody – Bundibugyo Ebolavirus<br />
-**[[6u55]], [[6u54]], [[6u52]], [[6u51]] - NP C-terminal + antibody – Sudan Ebolavirus<br />
-*Nucleoprotein other complexes
-**[[3mx2]], [[3mx5]] – LvNP + nucleotide<br />
-**[[2wyy]] – VvNP + poly U – Cryo EM<br />
-**[[3hhw]], [[3pmk]] – VvNP + phosphoprotein<br />r />
-**[[4co6]] - NP + phosphoprotein – Nipah virus<br />
-**[[4ucc]] – RsvNP N terminal + inhibitor<br />
-**[[4ucb]], [[4uca]] – RsvNP N terminal + phosphoprotein<br />
-**[[4uc9]], [[4uc8]] – RsvNP N terminal + phosphoprotein peptide<br />
-**[[3ro5]], [[4dya]], [[4dyb]], [[4dyn]], [[4dyp]], [[3tg6]] – IvNP + ligand<br />
-**[[4kxj]] – ScvNP N terminal + PJ34 <br />
-**[[4li4]], [[4lm7]], [[4lm9]], [[4lmc]] – ScvNP N terminal + nucleotide <br />
-**[[4lmt]] – ScvNP N terminal + quinoline derivative <br />
-**[[4ypi]] - EvNP + peptide – Cryo EM<br />
-**[[6ehm]] - EvNP + VP24 – Cryo EM<br />
-**[[5vao]], [[5vap]] - EvNP VP30 + NP peptide <br />
-**[[5sxq]], [[5f5o]] - LvmvNP + VP35 peptide <br />
-**[[5ip3]] - TsvNP + DNA <br />
-**[[5fvd]] - HmpvNP + phosphoprotein<br />
-**[[5wkn]] - PivNP + phosphoprotein<br />
-*'''Ribonucleoprotein'''
-**[[2lbw]] – yRNP subunit 2 residues 36-156 (mutant) – yeast – NMR<br />
-**[[2lbx]] - yRNP subunit 2 residues 36-156 – NMR<br />
-**[[4h5l]], [[4csg]], [[5fva]] – TvRNP – Toscana virus<br />
-**[[4csf]] – TvRNP + RNA<br />
-**[[4uft]] – MevRNP + RNA <br />
-*'''Small nuclear ribonucleoprotein'''
-**[[2a3j]], [[1fht]] - h-snRNP U1 A RRM – human - NMR<br />
-**[[2u1a]] - h-snRNP U1 A RRM (mutant) – NMR<br />
-**[[1dz5]] - h-snRNP U1 A  (mutant) – NMR<br />
-**[[1oia]] - h-snRNP U1 A RRM<br />
-**[[2l5i]], [[2l5j]] - h-snRNP U1 70kDa residues 131-151 – NMR<br />
-**[[2vy4]], [[2vy5]] - h-snRNP U11/U12 – NMR<br />
-**[[2cqj]] - h-snRNP U3 S4 domain – NMR<br />
-**[[1x4q]] - h-snRNP U4/U6 PWI domain - NMR<br />
-**[[2vrd]] - h-snRNP U1 C zinc finger domain - NMR<br />
-**[[1b34]] - h-snRNP D1 + h-snRNP D2<br />
-**[[1d3b]] - h-snRNP SM D3 SM motif + h-snRNP-associated protein<br />
-**[[1khm]] - h-snRNP K C terminal (mutant) – NMR<br />
-**[[2k3k]] – Dm-snRNP U1 A RRM1 – ''Drosophila melanogaster'' – NMR<br />
-**[[2aym]] - Dm-snRNP U1 A<br />
-**[[2b0g]] - Dm-snRNP U1 A RBD2 – NMR<br />
-**[[1n9r]], [[1n9s]] – y-snRNP F
-*Small nuclear ribonucleoprotein binary complex
-**[[3plu]], [[3plv]] – y-snRNP HINDI domain + ubiquitin-like modifier HUB1<br />
-**[[4wzj]] – h-snRNP  U4 core domain<br />
-**[[3p49]] - h-snRNP A RRM + glycine riboswitch RNA<br />
-**[[3iwn]] - h-snRNP U1 A RRM (mutant) + riboswitch RNA<br />
-**[[3pgw]], [[3mum]], [[3mur]], [[3mut]], [[3muv]], [[3egz]] - h-snRNP U1 A + DNA riboswitch<br />
-**[[3mxh]], [[3irw]] - h-snRNP U1 A (mutant) + DNA riboswitch<br />
-**[[3k0j]], [[1drz]], [[1m5k]], [[1m5o]], [[1m5p]], [[1m5v]], [[1u6b]], [[3ucu]], [[3ucz]], [[3ud3]], [[3ud4]] - h-snRNP U1 A (mutant) + RNA<br />
-**[[3bo2]], [[3bo3]], [[3bo4]] - h-snRNP U1 A RRM + RNA<br />
-**[[1sj3]], [[1sj4]], [[1sjf]], [[1vbx]], [[1vby]], [[1vbz]], [[1vc0]], [[1vc5]], [[1vc6]], [[4prf]] - h-snRNP U1 A (mutant) + Hepatitis ribozyme<br />
-**[[3r1h]], [[3r1l]] - h-snRNP U1 A (mutant) + ribozyme<br />
-**[[1aud]] - h-snRNP U1 A (mutant) + RNA - NMR<br />
-**[[3iin]] - h-snRNP U1 A (mutant) + group I intron + DNA<br />
-**[[4c4w]] - h-snRNP A RRM 1 + TSKT K-turn motif + ribosomal protein L7AE<br />
-**[[3b02]], [[3b03]], [[3b04]] - h-snRNP U1 A RRM1 + group I intron + RNA<br />
-**[[1zzn]] - h-snRNP U1 A RRM1 (mutant) + group I intron + RNA<br />
-**[[3l3c]], [[3g8s]], [[3g8t]], [[3g96]], [[3g9c]], [[2nz4]] - h-snRNP U1 A (mutant) + GLMS ribozyme + RNA<br />
-**[[3hhn]] - h-snRNP U1 A (mutant) + class I ligase ribozyme<br />
-**[[2oih]], [[2oj3]] - h-snRNP U1 A + HDV ribozyme<br />
-**[[3cul]], [[3cun]] - h-snRNP U1 A (mutant) + aminoacyl-tRNA synthetase ribozyme<br />
-**[[3cw1]] - h-snRNP U1 in spliceosome<br />
-**[[2ozb]], [[3siu]], [[3siv]] - h-snRNP U4/U6 + NHP2-like protein + RNA<br />
-**[[5xjl]], [[4v98]], [[4f7u]] - h-snRNP 8S assembly<br />
-**[[4m77]], [[4m78]], [[4m7a]], [[4m7d]] - h-snRNP LSM8 assembly<br />
-**[[2bn5]] - Dm-snRNP U1 70kDa + PSI B box – NMR<br />
-*'''Heterogenous nuclear ribonucleoprotein'''
-**[[3s01]] – m-hnRNP L RRM3 domain – mouse<br />
-**[[3tyt]] - m-hnRNP L<br />
-**[[2e5i]] - m-hnRNP L RRM – NMR<br />
-**[[2db1]] - m-hnRNP F RRM – NMR<br />
-**[[1ha1]], [[1l3k]], [[1up1]] - h-hnRNP A1 RRM<br />
-**[[2lyv]] - h-hnRNP A1 RRM 1-2 – NMR<br />
-**[[2up1]] - h-hnRNP A1 RRM 1-2 + DNA<br />
-**[[3s7r]] - h-hnRNP A/B<br />
-**[[1x4b]] - h-hnRNP A2/B1 RRM – NMR<br />
-**[[1txp]] - h-hnRNP C oligomerization domain – NMR<br />
-**[[1wf2]] - h-hnRNP C1/C2 RRM – NMR<br />
-**[[1hd0]], [[1hd1]], [[1iqt]] - h-hnRNP D0 RRM – NMR<br />
-**[[2hgl]], [[2hgm]], [[2hgn]] - h-hnRNP F QRRM – NMR<br />
-**[[1wg5]], [[1wez]], [[2lxu]] - h-hnRNP H RRM – NMR<br />
-**[[2ad9]], [[2adb]], [[2adc]] - h-hnRNP I – NMR<br />
-**[[1zzk]] - h-hnRNP K KH domain<br />
-**[[3r27]], [[3t08]] - h-hnRNP L RRM<br />
-**[[2do0]], [[2dh9]], [[2dgv]] - h-hnRNP M RRM – NMR<br />
-**[[2dgu]] - h-hnRNP Q RRM – NMR<br />
-**[[2dk2]] - h-hnRNP R RRM – NMR<br />
-*Heterogenous nuclear ribonucleoprotein binary complex
-**[[2kfy]], [[2kg0]], [[2kg1]] - h-hnRNP F QRRM + DNA – NMR<br />
-**[[2z5n]], [[2z5o]], [[2ot8]] - h-hnRNP D0 CTD + transportin-1<br />
-**[[1u1k]], [[1u1l]], [[1u1m]], [[1u1n]], [[1u1o]], [[1u1p]], [[1u1q]], [[1u1r]], [[1up1]] - h-hnRNP A1 RRM + DNA<br />
-**[[1pgz]], [[1po6]] - h-hnRNP A1 + DNA + inhibitor<br />
-**[[1wtb]], [[1x0f]] - h-hnRNP D0 RRM + DNA – NMR<br />
-**[[1zzi]], [[1zzj]] - h-hnRNP K KH domain + DNA<br />
-**[[1j5k]] - h-hnRNP K KH domain + DNA – NMR
-}}
 == References ==
 <references/>
 [[Category:Topic Page]]