Nudix hydrolase
From Proteopedia
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== Function == | == Function == | ||
| - | '''Nudix hydrolase''' (NDX) hydrolyses a wide range of organic pyrophosphatases including nucleoside di- and triphosphates, dinucleoside and diphosphoinositol polyphosphates, nucleotide sugars and RNA caps<ref>PMID:16378245</ref>. In prokaryotes the number of Nudix genes varies from 0 to over 30. Mammals have around 24 Nudix genes. NDX proteins contain the GX5EX7REUXEEXGU signature sequence<ref>PMID:9694840</ref>. | + | '''Nudix hydrolase''' (NDX) hydrolyses a wide range of organic pyrophosphatases including nucleoside di- and triphosphates, dinucleoside and diphosphoinositol polyphosphates, nucleotide sugars and RNA caps<ref>PMID:16378245</ref>. In prokaryotes the number of Nudix genes varies from 0 to over 30. Mammals have around 24 Nudix genes. NDX proteins contain the GX5EX7REUXEEXGU signature sequence<ref>PMID:9694840</ref>. Human NDX 16 is called '''U8-SNORNA-capping enzyme'''. |
== Relevance == | == Relevance == | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | + | [[3mgm]] – hNDX 16 - human <br /> | |
| + | [[5vy2]], [[5w6z]], [[5wji]] – hNDX 16 (mutant) <br /> | ||
| + | [[6b09]] – hNDX 16 (mutant) + DIDPR <br /> | ||
| + | [5w6x]] – hNDX 16 (mutant) + ADP-ribose <br /> | ||
| + | [[2xsq]] – hNDX 16 + IMP <br /> | ||
[[2b0v]], [[3cng]] - NDX - ''Nitrosomonas europaea''<br /> | [[2b0v]], [[3cng]] - NDX - ''Nitrosomonas europaea''<br /> | ||
[[1k2e]], [[1jrk]], [[1k26]] - NDX (mutant) - ''Pyrobaculum aerophilum''<br /> | [[1k2e]], [[1jrk]], [[1k26]] - NDX (mutant) - ''Pyrobaculum aerophilum''<br /> | ||
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[[3id9]], [[3smd]] - NDX - ''Bacillus thuringiensis''<br /> | [[3id9]], [[3smd]] - NDX - ''Bacillus thuringiensis''<br /> | ||
[[4dyw]] - NDX - ''Burkholderia pseudomallei''<br /> | [[4dyw]] - NDX - ''Burkholderia pseudomallei''<br /> | ||
| + | [[6dby]], [[5wwd]] – AtNDX 1 - ''Arabidopsis thaliana''<br /> | ||
| + | [[5wy6]] – AtNDX 1 (mutant) <br /> | ||
| + | [[6fl4]] – AtNDX 1 + 8-oxo-DGTP <br /> | ||
| + | [[6dbz]] – AtNDX 1 + isopentenyl phosphate <br /> | ||
| + | [[5gp0]] – AtNDX 1 + geranyl diphosphate <br /> | ||
| + | [[4zb3]] – AtNDX 7 <br /> | ||
| + | [[4zbp]] – AtNDX 7 + AMPCPR <br /> | ||
| + | [[5gg5]] – MsMuTT 1 – ''Mycobacterium smegmatis'' <br /> | ||
| + | [[5ggc]], [[5ggd]] – MsMuTT 1 + phosphate <br /> | ||
| + | [[5xd3]], [[5xd4]] – MsMuTT 1 + ATP <br /> | ||
| + | [[5gg6]] – MsMuTT 1 + 8-oxo-DGTP <br /> | ||
| + | [[5ggb]] – MsMuTT 1 + 8-oxo-DGDP <br /> | ||
| + | [[5gg7]], [[5gg8]], [[5gg9]], [[5gga]] – MsMuTT 1 + 8-oxo-DGTP + 8-oxo-DGMP + pyrophosphate<br /> | ||
| + | [[5xd1]], [[5xd2]] – MsMuTT 1 + AP5A + ATP <br /> | ||
| + | [[5xd5]] – MsMuTT 1 + phosphate + ATP<br /> | ||
| + | [[1vcd]], [[1vc8]] – TtNDX 1 + AP6A – ''Thermus thermophilus'' <br /> | ||
| + | [[1vc9]] – TtNDX 1 (mutant) + ATP <br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:26, 12 November 2019
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3D structures of Nudix hydrolase
Updated on 12-November-2019
3mgm – hNDX 16 - human
5vy2, 5w6z, 5wji – hNDX 16 (mutant)
6b09 – hNDX 16 (mutant) + DIDPR
[5w6x]] – hNDX 16 (mutant) + ADP-ribose
2xsq – hNDX 16 + IMP
2b0v, 3cng - NDX - Nitrosomonas europaea
1k2e, 1jrk, 1k26 - NDX (mutant) - Pyrobaculum aerophilum
1sjy, 1soi, 2w4e - DrNDX - Deinococcus radiodurans
1su2 - DrNDX + ATP
1sz3 - DrNDX + GNP
3fcm, 3f6a - NDX - Clostridium perfringens
3qsj - NDX - Alicyclobacillus acidocaldarius
3r03 - NDX - Rhodospirillum rubrum
2azw, 2fml - NDX - Enterococcus faecalis
2b06, 2pqv - NDX - Streptococcus pneumoniae
3exq - NDX - Lactobacillus brevis
3i9x - NDX - Listeria innocua
3id9, 3smd - NDX - Bacillus thuringiensis
4dyw - NDX - Burkholderia pseudomallei
6dby, 5wwd – AtNDX 1 - Arabidopsis thaliana
5wy6 – AtNDX 1 (mutant)
6fl4 – AtNDX 1 + 8-oxo-DGTP
6dbz – AtNDX 1 + isopentenyl phosphate
5gp0 – AtNDX 1 + geranyl diphosphate
4zb3 – AtNDX 7
4zbp – AtNDX 7 + AMPCPR
5gg5 – MsMuTT 1 – Mycobacterium smegmatis
5ggc, 5ggd – MsMuTT 1 + phosphate
5xd3, 5xd4 – MsMuTT 1 + ATP
5gg6 – MsMuTT 1 + 8-oxo-DGTP
5ggb – MsMuTT 1 + 8-oxo-DGDP
5gg7, 5gg8, 5gg9, 5gga – MsMuTT 1 + 8-oxo-DGTP + 8-oxo-DGMP + pyrophosphate
5xd1, 5xd2 – MsMuTT 1 + AP5A + ATP
5xd5 – MsMuTT 1 + phosphate + ATP
1vcd, 1vc8 – TtNDX 1 + AP6A – Thermus thermophilus
1vc9 – TtNDX 1 (mutant) + ATP
References
- ↑ McLennan AG. The Nudix hydrolase superfamily. Cell Mol Life Sci. 2006 Jan;63(2):123-43. doi: 10.1007/s00018-005-5386-7. PMID:16378245 doi:http://dx.doi.org/10.1007/s00018-005-5386-7
- ↑ Sheikh S, O'Handley SF, Dunn CA, Bessman MJ. Identification and characterization of the Nudix hydrolase from the Archaeon, Methanococcus jannaschii, as a highly specific ADP-ribose pyrophosphatase. J Biol Chem. 1998 Aug 14;273(33):20924-8. PMID:9694840
- ↑ McLennan AG. The MutT motif family of nucleotide phosphohydrolases in man and human pathogens (review). Int J Mol Med. 1999 Jul;4(1):79-89. PMID:10373642
- ↑ Ranatunga W, Hill EE, Mooster JL, Holbrook EL, Schulze-Gahmen U, Xu W, Bessman MJ, Brenner SE, Holbrook SR. Structural studies of the Nudix hydrolase DR1025 from Deinococcus radiodurans and its ligand complexes. J Mol Biol. 2004 May 21;339(1):103-16. PMID:15123424 doi:http://dx.doi.org/10.1016/j.jmb.2004.01.065
