Nudix hydrolase

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The structure contains the NDX signature sequence and <scene name='48/488532/Cv/5'>the bound ligand is seen interacting with both monomers and with the Mg+2 ions</scene><ref>PMID:15123424</ref>. Monomer A is colored deepskyblue, monomer B is colored salmon, water molecules are shown as red spheres.
The structure contains the NDX signature sequence and <scene name='48/488532/Cv/5'>the bound ligand is seen interacting with both monomers and with the Mg+2 ions</scene><ref>PMID:15123424</ref>. Monomer A is colored deepskyblue, monomer B is colored salmon, water molecules are shown as red spheres.
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==3D structures of Nudix hydrolase==
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[[Nudix hydrolase 3D structures]]
</StructureSection>
</StructureSection>
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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*Nudix hydrolase
 +
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**[[2b0v]], [[3cng]] - NDX - ''Nitrosomonas europaea''<br />
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**[[1k2e]], [[1jrk]], [[1k26]] - NDX (mutant) - ''Pyrobaculum aerophilum''<br />
 +
**[[1sjy]], [[1soi]], [[2w4e]] - DrNDX - ''Deinococcus radiodurans''<br />
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**[[1su2]] - DrNDX + ATP <br />
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**[[1sz3]] - DrNDX + GNP <br />
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**[[3fcm]], [[3f6a]] - NDX - ''Clostridium perfringens'' <br />
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**[[3qsj]] - NDX - ''Alicyclobacillus acidocaldarius''<br />
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**[[3r03]] - NDX - ''Rhodospirillum rubrum'' <br />
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**[[2azw]], [[2fml]] - NDX - ''Enterococcus faecalis''<br />
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**[[2b06]], [[2pqv]] - NDX - ''Streptococcus pneumoniae'' <br />
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**[[3exq]] - NDX - ''Lactobacillus brevis''<br />
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**[[3i9x]] - NDX - ''Listeria innocua''<br />
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**[[3id9]], [[3smd]] - NDX - ''Bacillus thuringiensis''<br />
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**[[4dyw]] - NDX - ''Burkholderia pseudomallei''<br />
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*Nudix hydrolase 1
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**[[6dby]], [[5wwd]] – AtNDX 1 - ''Arabidopsis thaliana''<br />
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**[[5wy6]] – AtNDX 1 (mutant) <br />
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**[[6fl4]] – AtNDX 1 + 8-oxo-DGTP <br />
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**[[6dbz]] – AtNDX 1 + isopentenyl phosphate <br />
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**[[5gp0]] – AtNDX 1 + geranyl diphosphate <br />
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**[[5gg5]] – MsMuTT 1 – ''Mycobacterium smegmatis'' <br />
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**[[5ggc]], [[5ggd]] – MsMuTT 1 + phosphate <br />
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**[[5xd3]], [[5xd4]] – MsMuTT 1 + ATP <br />
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**[[5gg6]] – MsMuTT 1 + 8-oxo-DGTP <br />
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**[[5ggb]] – MsMuTT 1 + 8-oxo-DGDP <br />
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**[[5gg7]], [[5gg8]], [[5gg9]], [[5gga]] – MsMuTT 1 + 8-oxo-DGTP + 8-oxo-DGMP + pyrophosphate<br />
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**[[5xd1]], [[5xd2]] – MsMuTT 1 + AP5A + ATP <br />
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**[[5xd5]] – MsMuTT 1 + phosphate + ATP<br />
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**[[1vcd]], [[1vc8]] – TtNDX 1 + AP6A – ''Thermus thermophilus'' <br />
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**[[1vc9]] – TtNDX 1 (mutant) + ATP <br />
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*Nudix hydrolase 7
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**[[4zb3]] – AtNDX 7 <br />
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**[[4zbp]] – AtNDX 7 + AMPCPR <br />
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[[3mgm]] – hNDX 16 - human <br />
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*Nudix hydrolase
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[[5vy2]], [[5w6z]], [[5wji]] – hNDX 16 (mutant) <br />
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-
[[6b09]] – hNDX 16 (mutant) + DIDPR <br />
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-
[5w6x]] – hNDX 16 (mutant) + ADP-ribose <br />
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-
[[2xsq]] – hNDX 16 + IMP <br />
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-
[[2b0v]], [[3cng]] - NDX - ''Nitrosomonas europaea''<br />
+
-
[[1k2e]], [[1jrk]], [[1k26]] - NDX (mutant) - ''Pyrobaculum aerophilum''<br />
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-
[[1sjy]], [[1soi]], [[2w4e]] - DrNDX - ''Deinococcus radiodurans''<br />
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-
[[1su2]] - DrNDX + ATP <br />
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-
[[1sz3]] - DrNDX + GNP <br />
+
-
[[3fcm]], [[3f6a]] - NDX - ''Clostridium perfringens'' <br />
+
-
[[3qsj]] - NDX - ''Alicyclobacillus acidocaldarius''<br />
+
-
[[3r03]] - NDX - ''Rhodospirillum rubrum'' <br />
+
-
[[2azw]], [[2fml]] - NDX - ''Enterococcus faecalis''<br />
+
-
[[2b06]], [[2pqv]] - NDX - ''Streptococcus pneumoniae'' <br />
+
-
[[3exq]] - NDX - ''Lactobacillus brevis''<br />
+
-
[[3i9x]] - NDX - ''Listeria innocua''<br />
+
-
[[3id9]], [[3smd]] - NDX - ''Bacillus thuringiensis''<br />
+
-
[[4dyw]] - NDX - ''Burkholderia pseudomallei''<br />
+
-
[[6dby]], [[5wwd]] – AtNDX 1 - ''Arabidopsis thaliana''<br />
+
-
[[5wy6]] – AtNDX 1 (mutant) <br />
+
-
[[6fl4]] – AtNDX 1 + 8-oxo-DGTP <br />
+
-
[[6dbz]] – AtNDX 1 + isopentenyl phosphate <br />
+
-
[[5gp0]] – AtNDX 1 + geranyl diphosphate <br />
+
-
[[4zb3]] – AtNDX 7 <br />
+
-
[[4zbp]] – AtNDX 7 + AMPCPR <br />
+
-
[[5gg5]] – MsMuTT 1 – ''Mycobacterium smegmatis'' <br />
+
-
[[5ggc]], [[5ggd]] – MsMuTT 1 + phosphate <br />
+
-
[[5xd3]], [[5xd4]] – MsMuTT 1 + ATP <br />
+
-
[[5gg6]] – MsMuTT 1 + 8-oxo-DGTP <br />
+
-
[[5ggb]] – MsMuTT 1 + 8-oxo-DGDP <br />
+
-
[[5gg7]], [[5gg8]], [[5gg9]], [[5gga]] – MsMuTT 1 + 8-oxo-DGTP + 8-oxo-DGMP + pyrophosphate<br />
+
-
[[5xd1]], [[5xd2]] – MsMuTT 1 + AP5A + ATP <br />
+
-
[[5xd5]] – MsMuTT 1 + phosphate + ATP<br />
+
-
[[1vcd]], [[1vc8]] – TtNDX 1 + AP6A – ''Thermus thermophilus'' <br />
+
-
[[1vc9]] – TtNDX 1 (mutant) + ATP <br />
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 +
**[[3mgm]] – hNDX 16 - human <br />
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**[[5vy2]], [[5w6z]], [[5wji]] – hNDX 16 (mutant) <br />
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**[[6b09]] – hNDX 16 (mutant) + DIDPR <br />
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**[[5w6x]] – hNDX 16 (mutant) + ADP-ribose <br />
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**[[2xsq]] – hNDX 16 + IMP <br />
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}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:37, 12 November 2019

Structure of Nudix hydrolase MutT complex with ATP and Mg+2 ion (green) (PDB entry 1su2)

Drag the structure with the mouse to rotate

3D structures of Nudix hydrolase

Updated on 12-November-2019 Updated on 12-November-2019

References

  1. ↑ McLennan AG. The Nudix hydrolase superfamily. Cell Mol Life Sci. 2006 Jan;63(2):123-43. doi: 10.1007/s00018-005-5386-7. PMID:16378245 doi:http://dx.doi.org/10.1007/s00018-005-5386-7
  2. ↑ Sheikh S, O'Handley SF, Dunn CA, Bessman MJ. Identification and characterization of the Nudix hydrolase from the Archaeon, Methanococcus jannaschii, as a highly specific ADP-ribose pyrophosphatase. J Biol Chem. 1998 Aug 14;273(33):20924-8. PMID:9694840
  3. ↑ McLennan AG. The MutT motif family of nucleotide phosphohydrolases in man and human pathogens (review). Int J Mol Med. 1999 Jul;4(1):79-89. PMID:10373642
  4. ↑ Ranatunga W, Hill EE, Mooster JL, Holbrook EL, Schulze-Gahmen U, Xu W, Bessman MJ, Brenner SE, Holbrook SR. Structural studies of the Nudix hydrolase DR1025 from Deinococcus radiodurans and its ligand complexes. J Mol Biol. 2004 May 21;339(1):103-16. PMID:15123424 doi:http://dx.doi.org/10.1016/j.jmb.2004.01.065

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Michal Harel, Alexander Berchansky, Tihitina Y Aytenfisu

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