O-GlcNAc transferase
From Proteopedia
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| - | ==3D structures of O-GlcNAc transferase== | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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| - | *O-GlcNAc transferase Domains: TPR 16-400; TPR+catalytic 323-1041; P110 197-915 | ||
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| - | **[[1w3b]] – hOGT TPR domain – human | ||
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| - | **[[6eou]] - hOGT TPR domain (mutant) <br /> | ||
| - | **[[1fo8]], [[1fo9]], [[1foa]] - rOGT catalytic domain – rabbit | ||
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| - | **[[2gak]] – mOGT – mouse | ||
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| - | **[[2j0a]], [[3otk]] – mOGT catalytic domain (mutant)<br /> | ||
| - | **[[5a01]] - DmOGT TPR and catalytic domains – ''Drosophila melanogaster''<br /> | ||
| - | **[[5djs]] - OGT TPR and catalytic domains (mutant) – ''Thermobaculum terrenum''<br /> | ||
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| - | *O-GlcNAc transferase binary complexes | ||
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| - | **[[3pe3]], [[3pe4]] – hOGT TPR and catalytic domains+ peptide substrate | ||
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| - | **[[4cdr]] - hOGT TPR and catalytic domains + UDP-peptide conjugate<br /> | ||
| - | **[[5bnw]], [[3tax]], [[6ibo]] - hOGT TPR and catalytic domains + substrate peptide <br /> | ||
| - | **[[4gz5]], [[4gz6]] - hOGT TPR and catalytic domains + UDP-GlcNAc<br /> | ||
| - | **[[6e37]], [[5vif]], [[5vie]] - hOGT P110 subunit + peptide<br /> | ||
| - | **[[5hgv]] - hOGT P110 subunit (mutant) + peptide<br /> | ||
| - | **[[5nps]], [[5npr]] - hOGT P110 subunit + inhibitor<br /> | ||
| - | **[[2am3]], [[2am4]] - rOGT catalytic domain + UDP-glucose derivative | ||
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| - | **[[2am5]] - rOGT catalytic domain + UDP | ||
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| - | **[[2apc]] - rOGT catalytic domain + UDP-GlcNAc phosphonate | ||
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| - | **[[2j0b]] - mOGT catalytic domain (mutant) + UDP | ||
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| - | **[[2jlb]] – XcOGT + UDP-GlcNAc phosphonate analog – ''Xanthomonas campestris'' | ||
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| - | **[[2xgm]] – XcOGT + alloxan + mesoxalylurea | ||
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| - | **[[2xgo]] - XcOGT + UDP-GlcNAc | ||
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| - | **[[2xgs]] - XcOGT + UDP | ||
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| - | *OGT higher complexes | ||
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| - | **[[3ee5]] – hOGT + UDP + NAG + galactose + naphthalene derivative<br /> | ||
| - | **[[4ay5]], [[4gyw]], [[4gyy]], [[4gz3]] - hOGT TPR and catalytic domains + UDP + NAG + glycopeptide<br /> | ||
| - | **[[4n39]], [[4n3a]], [[4n3b]], [[4n3c]] - hOGT TPR and catalytic domains + UDP + host cell factor peptide<br /> | ||
| - | **[[4xi9]], [[4xif]], [[4ay6]] - hOGT TPR and catalytic domains + UDP-GlcNac + substrate peptide<br /> | ||
| - | **[[6ma5]], [[6ma4]], [[6ma3]], [[6ma2]], [[6ma1]] - hOGT P110 subunit + host cell factor peptide + inhibitor<br /> | ||
| - | **[[5lvv]] - hOGT P110 subunit + UDP + NAG<br /> | ||
| - | **[[5c1d]], [[5bnw]] - hOGT P110 subunit + UDP-GlcNac + peptide<br /> | ||
| - | **[[2gam]] - mOGT + b-D-galactose + N-acetyl-galactosamine<br /> | ||
| - | **[[2xgm]] – XcOGT + alloxan + mesoxalylurea<br /> | ||
| - | **[[4pqg]] - OGT TPR and catalytic domains + UDP + GlcNac – ''Streptococcus pneumoniae''<br /> | ||
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| - | *MurG:UDP-GlcNac | ||
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| - | **[[3s2u]] - MurG + UDP-GlcNac – ''Pseudomonas aeruginosa''<br /> | ||
| - | **[[1nlm]] – EcMurG + UDP-GlcNac – ''Escherichia coli''<br /> | ||
| - | **[[1f0k]] – EcMurG <br /> | ||
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| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:47, 12 November 2019
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References
- ↑ Pathak S, Alonso J, Schimpl M, Rafie K, Blair DE, Borodkin VS, Schuttelkopf AW, Albarbarawi O, van Aalten DM. The active site of O-GlcNAc transferase imposes constraints on substrate sequence. Nat Struct Mol Biol. 2015 Aug 3. doi: 10.1038/nsmb.3063. PMID:26237509 doi:http://dx.doi.org/10.1038/nsmb.3063
- ↑ Hu Y, Chen L, Ha S, Gross B, Falcone B, Walker D, Mokhtarzadeh M, Walker S. Crystal structure of the MurG:UDP-GlcNAc complex reveals common structural principles of a superfamily of glycosyltransferases. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):845-9. Epub 2003 Jan 21. PMID:12538870 doi:10.1073/pnas.0235749100
- ↑ Lazarus MB, Jiang J, Gloster TM, Zandberg WF, Whitworth GE, Vocadlo DJ, Walker S. Structural snapshots of the reaction coordinate for O-GlcNAc transferase. Nat Chem Biol. 2012 Dec;8(12):966-8. doi: 10.1038/nchembio.1109. Epub 2012 Oct, 28. PMID:23103939 doi:http://dx.doi.org/10.1038/nchembio.1109
