1uzx
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(New page: 200px<br /> <applet load="1uzx" size="450" color="white" frame="true" align="right" spinBox="true" caption="1uzx, resolution 1.85Å" /> '''A COMPLEX OF THE VP...)
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Revision as of 15:41, 29 October 2007
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A COMPLEX OF THE VPS23 UEV WITH UBIQUITIN
Overview
The endosomal sorting complex required for transport (ESCRT-I) is a, 350-kDa complex of three proteins, Vps23, Vps28, and Vps37. The N-terminal, ubiquitin-conjugating enzyme E2 variant (UEV) domain of Vps23 is required, for sorting ubiquitinated proteins into the internal vesicles of, multivesicular bodies. UEVs are homologous to E2 ubiquitin ligases but, lack the conserved cysteine residue required for catalytic activity. The, crystal structure of the yeast Vps23 UEV in a complex with ubiquitin (Ub), shows the detailed interactions made with the bound Ub. Compared with the, solution structure of the Tsg101 UEV (the human homologue of Vps23) in the, absence of Ub, two loops that are conserved among the ESCRT-I UEVs move, toward each other to grip the Ub in a pincer-like grasp. The ... [(full description)]
About this Structure
1UZX is a [Protein complex] structure of sequences from [Saccharomyces cerevisiae] with SO4 and MES as [ligands]. Full crystallographic information is available from [OCA].
Reference
Structural insights into endosomal sorting complex required for transport (ESCRT-I) recognition of ubiquitinated proteins., Teo H, Veprintsev DB, Williams RL, J Biol Chem. 2004 Jul 2;279(27):28689-96. Epub 2004 Mar 24. PMID:15044434
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