103d

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[[Image:103d.jpg|left|200px]]
[[Image:103d.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 103d |SIZE=350|CAPTION= <scene name='initialview01'>103d</scene>
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The line below this paragraph, containing "STRUCTURE_103d", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_103d| PDB=103d | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=103d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=103d OCA], [http://www.ebi.ac.uk/pdbsum/103d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=103d RCSB]</span>
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}}
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'''THE UNUSUAL STRUCTURE OF THE HUMAN CENTROMERE (GGA)2 MOTIF: UNPAIRED GUANOSINE RESIDUES STACKED BETWEEN SHEARED G(DOT)A PAIRS'''
'''THE UNUSUAL STRUCTURE OF THE HUMAN CENTROMERE (GGA)2 MOTIF: UNPAIRED GUANOSINE RESIDUES STACKED BETWEEN SHEARED G(DOT)A PAIRS'''
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==About this Structure==
==About this Structure==
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103D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=103D OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=103D OCA].
==Reference==
==Reference==
The unusual structure of the human centromere (GGA)2 motif. Unpaired guanosine residues stacked between sheared G.A pairs., Chou SH, Zhu L, Reid BR, J Mol Biol. 1994 Dec 2;244(3):259-68. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7966337 7966337]
The unusual structure of the human centromere (GGA)2 motif. Unpaired guanosine residues stacked between sheared G.A pairs., Chou SH, Zhu L, Reid BR, J Mol Biol. 1994 Dec 2;244(3):259-68. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7966337 7966337]
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[[Category: Protein complex]]
 
[[Category: Chou, S H.]]
[[Category: Chou, S H.]]
[[Category: Reid, B R.]]
[[Category: Reid, B R.]]
[[Category: Zhu, L.]]
[[Category: Zhu, L.]]
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[[Category: dna]]
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[[Category: Dna]]
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[[Category: double helix]]
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[[Category: Double helix]]
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[[Category: g-g stacking]]
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[[Category: G-g stacking]]
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[[Category: g:a mismatch]]
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[[Category: G:a mismatch]]
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[[Category: ga-bracketed g-stack motif]]
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[[Category: Ga-bracketed g-stack motif]]
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[[Category: human centromere repeat]]
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[[Category: Human centromere repeat]]
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[[Category: nmr]]
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[[Category: Nmr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:24:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:26:21 2008''
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Revision as of 06:24, 2 May 2008

Image:103d.jpg

Template:STRUCTURE 103d

THE UNUSUAL STRUCTURE OF THE HUMAN CENTROMERE (GGA)2 MOTIF: UNPAIRED GUANOSINE RESIDUES STACKED BETWEEN SHEARED G(DOT)A PAIRS


Overview

The centromere of human chromosomes contains multiple repeats of the DNA sequence d(TGGAA)n. This sequence has the interesting property of pairing with itself to form stable duplexes. We have determined the solution structure of the unusual DNA duplex 5'-TGGAATGGAA:TGGAATGGAA-3' at atomic resolution. The duplex contains unpaired staggered guanosine residues, which co-stack by intercalation between sheared G.A and A.G base-pairs to form an interesting new structural motif, the GA-bracketed G-stack. The TGGAA repeat unit contains six "steps", four of which are not Watson-Crick base-pairs.

About this Structure

Full crystallographic information is available from OCA.

Reference

The unusual structure of the human centromere (GGA)2 motif. Unpaired guanosine residues stacked between sheared G.A pairs., Chou SH, Zhu L, Reid BR, J Mol Biol. 1994 Dec 2;244(3):259-68. PMID:7966337 Page seeded by OCA on Fri May 2 09:24:35 2008

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